Anatomical factors of human respiratory tract influencing volume flow rate and number of particles arriving at each bronchus

• Autorzy: Watanabe Jobu , Watanabe Mariko

Identyfikatory

DOI

10.1016/j.bbe.2019.03.004

• Języki publikacji: EN

Abstrakty

EN

Inhalants, such as bronchodilators, are often used to treat asthma. Numerical simulation can be applied to quantitatively evaluate the transport and deposition of medicinal particulates in the respiratory tract. In this study, numerical simulation of an airflow including particles in a tracheobronchial model was conducted based on a computed tomography (CT) image of a human respiratory tract, and then the anatomical factors of the airway that influence the volume flow rate and the number of particles arriving at each bronchus were investigated. The oral cavity, pharynx, larynx, trachea, and intra-thoracic central airways of up to seven generations were modeled from the CT image. The airflow was simulated by large eddy simulation using OpenFOAM ver. 2.3.1. The particle transport was calculated in a Lagrangian manner. Statistical analysis was performed on the results of computational fluid dynamics simulation. It was found that the cross-sectional area of the outlet boundary, the total distance of the center line of the respiratory tract between the carina and the outlet boundary, and the angles between each bronchus and the trachea have large influences on the volume flow rate at each outlet. These influences increase almost linearly as the inhalation flow rate increases. The outlet area and the total angle markedly influenced the number of arriving particles. Larger particles are more likely to be influenced by the angle at which the direction of the particle is deflected. As the inhalation flow rate increases, the influence of the total angle increases and that of the outlet area decreases in all particle conditions.

Słowa kluczowe

EN

computational fluid dynamics; generalized linear model; human respiratory tract; computed tomography image

PL

obliczeniowa mechanika płynów; uogólniony model liniowy; układ oddechowy człowieka; tomografia komputerowa

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2019
• Tom: Vol. 39, no. 2
• Strony: 526--535
• Opis fizyczny: Bibliogr. 26 poz., rys., wykr.

Twórcy

autor

Watanabe Jobu

• Department of Pharmaceutical Sciences, Teikyo Heisei University, 4-21-2 Nakano, Nakano-ku, Tokyo 164-8530, Japan

autor

Watanabe Mariko

• Department of Engineering and Applied Sciences, Sophia University, Tokyo Japan

Bibliografia

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Uwagi

PL

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2019).