Analysis of ciprofloxacin in low- and high-fat milk by high-performance liquid chromatography-mass spectrometry

Pápai, K; Budai, M; Ludányi, K; Antal, I; Klebovich, I

Artykuł - szczegóły

Tytuł artykułu

Analysis of ciprofloxacin in low- and high-fat milk by high-performance liquid chromatography-mass spectrometry

Autorzy

Pápai K , Budai M , Ludányi K , Antal I , Klebovich I

Wybrane pełne teksty z tego czasopisma

Identyfikatory

Warianty tytułu

Języki publikacji

Abstrakty

The quantitative analysis of antibiotics in different matrices is of increasing importance in in vitro studies of food-drug interactions in the drug-development process. Our objective was to develop a new, rapid and simple solid-phase extraction method without protein precipitation followed by high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS) for analysis of ciprofloxacin in low- and high-fat milk. The HPLC-MS method (a single-quadrupole mass spectrometer equipped with an electrospray ion source was used as detector) was validated using a quinolone derivative, aripiprazole, as internal standard. A C 8 column and gradient elution with 0.02 M ammonium acetate solution (pH 2.5) and acetonitrile mixtures (flow rate 0.5 mL min ^-1) were used for HPLC separation. Various modes of detection (diode-array detection and MS detection in scanning and selected-ion monitoring modes) were compared for selectivity and sensitivity of quantitative analysis of ciprofloxacin. Use of selected- ion monitoring resulted in a 1600:1 signal-to-noise ratio which can be successfully applied to milk matrices resulting in a lower limit of detection of 0.4 ng mL ^-1 and a lower limit of quantification of 4.0 ng mL ^-1. Recovery was 99.06 ± 0.15 and 98.57 ± 0.14% for low- and high-fat milk, respectively. The method enables analysis of the free, biologically available, amount of ciprofloxacin in in vitro simulation of milk-ciprofloxacin interaction studies.

Słowa kluczowe

ciprofloxacin milk solid-phase extraction liquid chromatography mass spectrometry

Wydawca

University of Silesia in Katowice
Akademiai Kiado

Czasopismo

Acta Chromatographica

Rocznik

2010

Tom

Vol. 22, no. 1

Strony

117--131

Opis fizyczny

Bibliogr. 68 poz., rys., tab.

Twórcy

autor

Pápai K

Semmelweis University Department of Pharmaceutics Hőgyes E. Str. 7 H-1092 Budapest Hungary

autor

Budai M

Semmelweis University Department of Pharmaceutics Hőgyes E. Str. 7 H-1092 Budapest Hungary

autor

Ludányi K

Semmelweis University Department of Pharmaceutics Hőgyes E. Str. 7 H-1092 Budapest Hungary

autor

Antal I

Semmelweis University Department of Pharmaceutics Hőgyes E. Str. 7 H-1092 Budapest Hungary

autor

Klebovich I

klebovich@gyok.sote.hu

Semmelweis University Department of Pharmaceutics Hőgyes E. Str. 7 H-1092 Budapest Hungary

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Typ dokumentu

Bibliografia

Identyfikator YADDA

bwmeta1.element.baztech-16923381-5e86-4558-904d-5069167a9fe9