Automated bimodal ultrasound device for preclinical testing of HIFU technique in treatment of solid tumors implanted into small animals

• Autorzy: Kujawska T. , Dera W. , Dziekoński C.
• Języki publikacji: EN

Abstrakty

EN

In Poland cancer is the second cause of death overall, and the first before 65. Demand for new anticancer therapies is increasing every year. The main objective of studies on medical and technical aspects of new anticancer methods is to reduce unwanted side effects and costs associated with conventional methods of treatment. Percutaneous (noninvasive) HIFU (High Intensity Focused Ultrasound) technique gives the chance to radically reduce both of these factors. The main goal of this work is automation of HIFU technology for producing thermal damage to the entire volume of a solid breast tumor implanted into a rat mammary gland using the proposed bi-modal ultrasound equipment, enabling the ultrasonic heating of a small volume within the tumor under the ultrasonic imaging control, as well as 3D scanning of the heating beam focus throughout the entire tumor volume. Design of the proposed equipment includes the heating probe of low frequency (about 1MHz), allowing penetration of pulsed focused waves into tissues, and the linear phased array probe of high frequency (from 4 MHz to 10 MHz), allowing visualization of the locally heated area inside the tumor in real time. Automatic 3D scanning of the heating beam focus provides the thermal damage to its entire volume.

Słowa kluczowe

EN

High Intensity Focused Ultrasound beam; focal volume; tissue damage

• Wydawca: Polskie Towarzystwo Akustyczne. Oddział Gdański
• Czasopismo: Hydroacoustics
• Rocznik: 2017
• Tom: Vol. 20
• Strony: 93--98
• Opis fizyczny: Bibliogr. 9 poz., rys.

Twórcy

autor

Kujawska T.

• Institute of Fundamental Technological Research of the Polish Academy of Sciences Pawińskiego 5b, 02-106 Warsaw, Poland

autor

Dera W.

• Institute of Fundamental Technological Research of the Polish Academy of Sciences Pawińskiego 5b, 02-106 Warsaw, Poland

autor

Dziekoński C.

• Institute of Fundamental Technological Research of the Polish Academy of Sciences Pawińskiego 5b, 02-106 Warsaw, Poland

Bibliografia

• [1] Azzouz H, de la Rosette JJMCH. HIFU: local treatment of prostate cancer. EAU-EBU Update Series 4: 62-70, 2006.
• [2] Chaussy CG, Thuroff S. Transrectal high-intensity focused ultrasound for local treatment of prostate cancer: current role. Arch Esp Urol 64(6): 493-506, 2011.
• [3] Zhou YF. High intensity focused ultrasound in clinical tumor ablation. World J Clin Oncol 2(1): 8-27, 2011.
• [4] Zavaglia C, Mancuso A, Foschi A, Rampoldi A. High-intensity focused ultrasound (HIFU) for the treatment of hepatocellular carcinoma: is it to abandon standard ablative percutaneous treatments? Hepatobiliary Surg Nutr 2(4): 184-187, 2013.
• [5] Zhou YF. Noninvasive treatment of breast cancer using high-intensity focused ultrasound. J Med Imaging Health Informatics 3: 141-156, 2013.
• [6] Zhang L, ChenWZ, Liu YJ, et al. Feasibility of magnetic resonance imaging-guided high intensity focused ultrasound therapy for ablating uterine fibroids in patients with bowel lying anterior to uterus. European Journal of Radiology 73: 396–403, 2010.
• [7] Ebbini ES, ter Haar G. Ultrasound-guided therapeutic focused ultrasound: current status and future directions. Int J Hyperthermia 31(2): 77-89, 2015.
• [8] Kujawska T, Secomski W, Byra M, Postema M, Nowicki A. Annular phased array transducer for preclinical testing of anti-cancer drug efficacy on small animals. Ultrasonics 76: 92–98, 2017.
• [9] Wójcik J, Kujawska T, Nowicki A, Lewin PA. Fast prediction of pulsed nonlinear acoustic fields from clinically relevant sources using time-averaged wave envelope approach: comparison of numerical simulations and experimental results. Ultrasonics 48: 707–715, 2008.

Uwagi

PL

Opracowanie w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).