New functional aliphatic polycarbonates – materials for advanced biomedical applications

• Autorzy: Pastusiak M. , Kawalec M. , Jaworska J. , Kurcok P. , Janeczek H. , Dobrzyński P.
• Konferencja: 24th Conference on Biomaterials in medicine and veterinary medicine : 9--12 October 2014, Rytro, Poland
• Języki publikacji: EN

Abstrakty

EN

The aim of this study is to develop a new method of synthesis of functional (co)polycarbonates by ring -opening polymerization of ethyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate (MTC-Et), benzyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate (MTC-Bz) and their copolymerization with 1,3-trimethylene carbonate (TMC) with potential application in the formation of bioresorbable scaffolds for living cells and drug delivery, systems for achieving controlled drug release. (Co)polymerizations were conducted in bulk, in the presence of low toxic lanthanum acetylacetonate - La(acac)3xH2O as catalyst. All synthesized materials were obtained at 120°C. The results are very promising. A series of (co) polymers were obtained with high conversion and relatively high molecular weights. The composition of the comonomers and their sequence lengths were determined by means 1H NMR and 13C NMR measurements. Higher reactivity during the investigated copolymerizations presented carbonates with pending ethyl or benzyl group than 1,3-trimethylene carbonate. The thermal properties obtained (co)polymers were characterized by differential scanning calorimetry.

Słowa kluczowe

EN

bioresorbable polymers; cyclic carbonates (co)polymerization; 1,3-trimethylene carbonate; functional polymers

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2014
• Tom: Vol. 17, no. 128-129
• Strony: 103--106
• Opis fizyczny: Bibliogr. 11 poz., rys., tab., wykr.

Twórcy

autor

Pastusiak M.

• Polish Academy of Sciences, Centre of Polymer and Carbon Materials, Zabrze, Poland

autor

Kawalec M.

• Polish Academy of Sciences, Centre of Polymer and Carbon Materials, Zabrze, Poland

autor

Jaworska J.

• Polish Academy of Sciences, Centre of Polymer and Carbon Materials, Zabrze, Poland

autor

Kurcok P.

• Polish Academy of Sciences, Centre of Polymer and Carbon Materials, Zabrze, Poland
• Jan Dlugosz University, Faculty of Mathematics and Natural Science, Czestochowa, Poland

autor

Janeczek H.

• Polish Academy of Sciences, Centre of Polymer and Carbon Materials, Zabrze, Poland

autor

Dobrzyński P.

• Polish Academy of Sciences, Centre of Polymer and Carbon Materials, Zabrze, Poland
• Jan Dlugosz University, Faculty of Mathematics and Natural Science, Czestochowa, Poland

Bibliografia

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• [8] Seow W. Y., Xue J. M., Yang Y. Y.: Targeted and Intracellular Delivery of Paclitaxel using Multi-functional Polymeric Micelles. Biomaterials 28 (2007) 1730–1740.
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• [10] Kawalec M., Dove A. P., Mespouille L., Dubois Ph.: Morpholine-functionalized polycarbonate hydrogels for heavy metal ion sequestration. Polymer Chemistry 4 (2013) 1260-1270.
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Uwagi

EN

This study was supported by the National Science Centre Poland, project No. UMO-2012/07/B/ST5/00616 “Novel copolymers of functionalized cyclic carbonates. Investigation of synthesis of novel, functional and biocompatible materials by coordination ring-opening polymerization“.