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Characteristic of polypropylene nanocomposite material reinforcement with hydroxyapatite for bone replacement

Treść / Zawartość
Identyfikatory
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Purpose: Human bone suffered some degeneration due to age and accidents; therefore, there are many interests in the prepared synthetic bone with properties nearer to natural bone. The present study prepared a nanocomposite of polypropylene reinforced with different weight fraction of Nano hydroxyapatite (HAp) to be used as a bone replacement with good biological properties that enhanced the growth of osteoplastic cells and enhance the prevention of clots and coagulates creation. Design/methodology/approach: Nanocomposite from polypropylene reinforced with different weight fraction of Hydroxyapatite (HAp) (1,2 and 3) % prepared by first dispersion Nano hydroxyapatite insolvent and then mixing with a pellet of polypropylene by the twin-screw extrusion process, the current research study the surface properties ( atomic force microscopy (AFM), contact angle test) Moreover, it studied the characteristics of prepared nanocomposite materials (Differential Scanning Calorimetry (DSC), Field Emission-Scanning Electron Microscopy (FE-SEM) and Fourier Transform Infrared (FTIR)). Findings: The AFM results show the surface roughness decreased with increasing content of HAp, which diminished the chance of creation clots and coagulates on it. The contact angle results referred to polypropylene behaviour transformed from hydrophobic to hydrophilic with addition HAp that permission to grow the osteoplastic cell on it, so the healing process is accelerated. Moreover, the FE-SEM images revealed uniform distribution and good bonding between polypropylene and Hydroxyapatite. The thermal properties were measured by the DSC test showed the melting temperature, and the enthalpy of melting (indicated to increase the crystalline structure per cent) are increased with increasing the percentage of Hydroxyapatite. Research limitations/implications: This research studied the characteristics of nanocomposite materials prepared by three steps (dispersion by ultrasonic device, manually mixed and melting and mixing by twin extruder) which can be used as a bone replacement. However, the main limitation was the uniform distribution of nano-hydroxyapatite within the matrix. In a further study, the cytotoxic test can be tested to study the effect of prepared nanocomposite on living cells’ growth. Practical implications: The interest object is how to connect among different properties to prepared bone replacement with good properties and biocompatibility that made able to stimulate the growth and healing process. Originality/value: The nano-hydroxyapatite is a biomaterial that has a composition similar to the natural mineral phase of the bone and does not have any negative effect, which enhanced the growth of osteoplastic cells and decreased the clots and coagulates creation; therefore, nano-hydroxyapatite is used to decrease the surface roughness which decreased the chance of coagulation creation and to enhance the hydrophilic properties.
Rocznik
Strony
21--30
Opis fizyczny
Bibliogr. 23 poz., rys., tab., wykr.
Twórcy
autor
  • Department of Polymer and Petrochemical Industries, College of Materials Engineering, University of Babylon, Hilla, Iraq
autor
  • Department of Polymer and Petrochemical Industries, College of Materials Engineering, University of Babylon, Hilla, Iraq
  • Department of Polymer and Petrochemical Industries, College of Materials Engineering, University of Babylon, Hilla, Iraq
Bibliografia
  • [1] C. Gao, S. Peng, P. Feng, C. Shuai, Bone biomaterials and interactions with stem cells, Bone Research 5 (2017) 17059. DOI: https://doi.org/10.1038/boneres.2017.59
  • [2] H. Lu, Y. Liu, J. Guo, H. Wu, J. Wang, G. Wu, Biomaterials with antibacterial and osteoinductive properties to repair infected bone defects, International Journal of Molecular Science 17/3 (2016) 334. DOI: https://doi.org/10.3390/ijms17030334
  • [3] A.V. Maksimkin, F.S. Senatov, N.Yu. Anisimova, M.V. Kiselevskiy, D.Yu. Zalepugin, I.V. Chernyshova, N.A. Tilkunova, S.D. Kaloshkin, Multilayer porous UHMWPE scaffolds for bone defects replacement, Materials Science and Engineering: C 73 (2017) 366-372. DOI: https://doi.org/10.1016/j.msec.2016.12.104
  • [4] L. Terranova, R. Mallet, R. Perrot, D. Chappard, Polystyrene scaffolds based on microfibers as a bone substitute; development and in vitro study, Acta Biomaterialia 29 (2016) 380-388. DOI: https://doi.org/10.1016/j.actbio.2015.10.042
  • [5] M. Montazerolghaem, A. Rasmusson, H. Melhus, H. Engqvist, M. Karlsson Ott, Simvastatin-doped pre-mixed calcium phosphate cement inhibits osteoclast differentiation and resorption, Journal of Materials Science: Materials in Medicine 27 (2016) 83. DOI: https://doi.org/10.1007/s10856-016-5692-7
  • [6] N. Shadjou, M. Hasanzadeh, Bone tissue engineering using silica-based mesoporous nanobiomaterials: recent progress, Materials Science and Engineering: C 55 (2015) 401-409. DOI: https://doi.org/10.1016/j.msec.2015.05.027
  • [7] R.Y. Basha, T.S. Sampath Kumar, M. Doble, Design of biocomposite materials for bone tissue regeneration, Materials Science and Engineering: C 57 (2015) 452-463. DOI: https://doi.org/10.1016/j.msec.2015.07.016
  • [8] K.W. Chan, H.M. Wong, K.W.K. Yeung, S.C. Tjong, Polypropylene Biocomposites with Boron Nitride and Nanohydroxyapatite Reinforcements, Materials 8 (2015) 992-1008. DOI: https://doi.org/10.3390/ma8030992
  • [9] L.C. Du, Y.Z. Meng, S.J. Wang, S.C. Tjong, Synthesis and degradation behavior of poly (propylene carbonate) derived from carbon dioxide and propylene oxide, Journal of Applied Polymer Science 92/3 (2004) 1840-1846. DOI: https://doi.org/10.1002/app.20165
  • [10] R. Orefice, A. Clark, J. West, A. Brennan, L. Hench, Processing, properties, and in vitrobioactivity of polysulfone-bioactive glass composites, Journal of Biomedical Material Research 80A/3 (2007) 565-580. DOI: https://doi.org/10.1002/jbm.a.30948
  • [11] Y. Liu, M. Wang, Fabrication and Characteristics of Hydroxyapatite Reinforced Polypropylene as a Bone Analogue Biomaterial, Journal of Applied Polymer Science 106/4 (2007) 2780-2790. DOI: https://doi.org/10.1002/app.26917
  • [12] C. Ramírez, C. Albano, A. Karam, N. Domínguez, Y. Sánchez, G. González,Mechanical, thermal, rheological and morphological behaviour of irradiated PP/HA composites, Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 236/1-4 (2005) 531-535. DOI: https://doi.org/10.1016/j.nimb.2005.04.034
  • [13] M. Wang, Bioceramics, in: Y. Ikada (ed.), Recent Research Developments in Biomaterials, Research Signpost, Trivandrum, 2002, 33-76.
  • [14] L.J. Chen, M. Wang, Production and evaluation of biodegradable composites based on PHB–PHV copolymer, Biomaterials 23/13 (2002) 2631-2639. DOI: https://doi.org/10.1016/S0142-9612(01)00394-5
  • [15] J. Ni, M. Wang, In vitro evaluation of hydroxyapatite reinforced polyhydroxybutyrate composite, Materials Science and Engineering: C 20/1 (2002) 101-109. DOI: https://doi.org/10.1016/S0928-4931(02)00019-X
  • [16] T. Guadalupe Peñaflor Galindo, Y. Chai, M. Tagaya, Hydroxyapatite Nanoparticle Coating on Polymer for Constructing Effective Biointeractive Interfaces, Journal of Nanomaterials 2019 (2019) 6495239. DOI: https://doi.org/10.1155/2019/6495239
  • [17] F. Ridi, I. Meazzini, B. Castroflorio, M. Bonini, D. Berti, P. Baglioni, Functional calcium phosphate composites in nanomedicine, Advances in Colloid and Interface Science 244 (2017) 281-295. DOI: https://doi.org/10.1016/j.cis.2016.03.006
  • [18] J. Fang, L. Zhang, D. Sutton, X. Wang, T. Lin, Needleless Melt-Electrospinning of Polypropylene Nanofibres, 2012 (2012) 382639. DOI:https://doi.org/10.1155/2012/382639
  • [19] J.K. Oleiwi, R.A. Anaee, S.A.H. Radhi, Compression and hardness with FTIR characterization of UHMWPE nanocomposites as acetabular cup in hip joint replacement, International Journal of Plastic and Polymer Technology 8/1 (2019) 1-10.
  • [20] N.A. Saad, M.N. Obaid, The synergetic Effect of Short Fibers of PAN and Nanoparticles (GNP/HAp) on Tribological Behavior and Surface Roughness of UHMWPE, Test Engineering and Management 83 (2020) 22000-22012.
  • [21] J.K. Oleiwi, R.A. Anaee, S.A.H. Radhi, Roughness, wear and thermal analysis of UHMWPE nanocomposites asacetabular cup in hip joint replacement, International Journal of Mechanical and Production Engineering Research and Development 8/6 (2018) 855-864. DOI: https://doi.org/10.24247/ijmperddec201887
  • [22] A.A. Hussein, O.H. Sabr, Preparation and facilitation of antibacterial activity, hydrophilicity of piezo–PVDF/n-MgO film by electro-spinning and spin coated for wound dressing: a comparative study, Journal of Mechanical Engineering Research and Developments 42/4 (2019) 23-31. DOI: http://doi.org/10.26480/jmerd.04.2019.23.31
  • [23] J.K. Oleiwi, R.A. Anaee, S.A.H. Radhi, Tensile Properties of UHMWPE Nanocomposites Reinforced by CNTs and nHA for Acetabular Cup in Hip Joint Replacement, Journal of Engineering and Applied Sciences 13/13SI (2018) 10649-10656. DOI: http://dx.doi.org/10.36478/jeasci.2018.10649.10656
Uwagi
PL
Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2021).
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-15be6c44-565b-443f-ad48-05f32552b1f9
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