Degradation analysis of radiosensitizer control release system based on the NMR spectroscopy

• Autorzy: Buszman A. , Kasperczyk J. , Jaworska J.
• Języki publikacji: EN

Abstrakty

EN

The degradation process of multilayer radiosensitizer releasing systems was conducted and examined via the nuclear magnetic resonance spectroscopy. Copolymers of glycolide and lactide with different chain microstructure were used as biocompatible drug carriers. Metronidazole was used as radiosensitizer. The changes of copolymers chain microstructure were monitored during 16 weeks of hydrolytic degradation of material in artificial Cerebro-spinal Fluid Solution. This study shows distinct differences in the rate of copolymer degradation and changes of the degree of randomness, directly connected with the type of comonomers and the comonomeric molar ratio. During 16 weeks of hydrolytic degradation, copolymers with L-lactidyl units remain resistant to hydrolysis while materials with D,L-lactidyl units are completely degraded. Examined materials can be used as carriers of agents for different types of short-, mid- and long-term therapies based on control release systems.

Słowa kluczowe

EN

biodegradable polyesters; NMR spectroscopy; hydrolytic degradation; polymeric chain microstructure

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2012
• Tom: Vol. 15, no. 113
• Strony: 16--18
• Opis fizyczny: Bibliogr. 11 poz., tab., wykr.

Twórcy

autor

Buszman A.

• Centre of Polymer and Carbon Materials PAS, M. Curie-Skłodowskiej 34 St., 41-819 Zabrze, Poland

autor

Kasperczyk J.

• Centre of Polymer and Carbon Materials PAS, M. Curie-Skłodowskiej 34 St., 41-819 Zabrze, Poland
• Department of Biopharmacy, School of Pharmacy and Division of Laboratory Medicine, Medical University OF Silesia, Narcyzów 1 St., 41-200 Sosnowiec, Poland

autor

Jaworska J.

• Centre of Polymer and Carbon Materials PAS, M. Curie-Skłodowskiej 34 St., 41-819 Zabrze, Poland

Bibliografia

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• [2] Kasperczyk J., Li S., Jaworska J., Dobrzyński P., Vert M.: Degradation of copolymers obtained by ring-opening copolymerization of glycolide and ε-caprolactone: A high resolution NMR and ESI-MS study. Polymer Degradation and Stability 95, 5 (2008) 990-999.
• [3] Jelonek K., Dobrzyński P., Li S., Kasperczyk J., Jarząbek B.: Controlled poly(L-lactide-co-trimethylene carbonate) delivery system of cyclosporine A and rapamycine - the effect of copolymer chain microstructure on drug release rate. International Journal of Pharmaceutics 414, 1-2 (2011) 203-209.
• [4] Buszman A., Kasperczyk J., Jarząbek B., Stokłosa K., Smola A.: Biodegradable polymeric system releasing radiosensitizer - the in vitro studies. Engineering of Biomaterials 99-101 (2010) 67-71.
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• [8] Jian Yang, Feng Liu, Liu Yang, Suming Li: Hydrolytic and enzymatic degradation of poly(trimethylene carbonate-co-D,L-lactide) random copolymers with shape memory behavior. European Polymer Journal 46, 4 (2010) 783-791.
• [9] Vert M., Mauduit J., Li S.: Biodegradation of PLA/GA polymers: increasing complexity: Biomaterials 15, 15 (1994) 1209-1213.
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Uwagi

EN

This work was supported by the European Community from the European Social Fund within the RFSD2 project and by the MEMSTEM Project contract no UDA -POIG 01.03.01-00-123-08/03