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Effect of curcumin and pirfenidone on toxicokinetics of paraquat in rat by UPLC–MS/MS

Identyfikatory
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The rats were randomly divided into paraquat group, curcumin treatment group, and pirfenidone treatment group. The concentration of paraquat in rat plasma was determined by an ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method over the range of 10–2000 ng mL−1. Chromatographic separation was achieved on a BEH HILIC (2.1 mm × 100 mm, 1.7 μm) column. The mobile phase was consisted of acetonitrile and 10 mm ammonium formate buffer (containing 0.1% formic acid) with gradient elution pumped at a flow rate of 0.4 mL min−1. Protein precipitation with acetonitrile was used as sample preparation. Compared with the paraquat group, there is statistical toxicokinetic difference for curcumin treatment group and pirfenidone treatment group, AUC(0 − t) decreased (P < 0.05), clearance (CL) increased (P < 0.05) for curcumin or pirfenidone treatment group, and Cmax decreased (P < 0.05) for curcumin treatment group. The results showed that treatment by curcumin and pirfenidone could relieve acute paraquat poisoning in rats.
Słowa kluczowe
Rocznik
Strony
26--30
Opis fizyczny
Bibliogr. 33 poz., rys., tab.
Twórcy
autor
  • Laboratory of Clinical Pharmacy, The People's Hospital of Lishui, Lishui 323000, China
autor
  • Analytical and Testing Center, Wenzhou Medical University, Wenzhou 325035, China
autor
  • Analytical and Testing Center, Wenzhou Medical University, Wenzhou 325035, China
autor
  • Analytical and Testing Center, Wenzhou Medical University, Wenzhou 325035, China
autor
  • Analytical and Testing Center, Wenzhou Medical University, Wenzhou 325035, China
autor
  • College of Plant Protection, Anhui Agricultural University, Hefei 230036, China
  • The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, 325000, China
autor
  • Analytical and Testing Center, Wenzhou Medical University, Wenzhou 325035, China
autor
  • Analytical and Testing Center, Wenzhou Medical University, Wenzhou 325035, China
Bibliografia
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Uwagi
PL
Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-13793737-d38a-4caa-aa5a-ad528b29b129
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