Effect of curcumin and pirfenidone on toxicokinetics of paraquat in rat by UPLC–MS/MS

Wang, S.; Lin, Z.; Su, K.; Zhang, J.; Zhang, L.; Gao, Z.; Ma, J.; Wang, X.

doi:10.1556/1326.2017.00175

Artykuł - szczegóły

Tytuł artykułu

Effect of curcumin and pirfenidone on toxicokinetics of paraquat in rat by UPLC–MS/MS

Autorzy

Wang S. , Lin Z. , Su K. , Zhang J. , Zhang L. , Gao Z. , Ma J. , Wang X.

Wybrane pełne teksty z tego czasopisma

Identyfikatory

DOI

10.1556/1326.2017.00175

Warianty tytułu

Języki publikacji

Abstrakty

The rats were randomly divided into paraquat group, curcumin treatment group, and pirfenidone treatment group. The concentration of paraquat in rat plasma was determined by an ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method over the range of 10–2000 ng mL−1. Chromatographic separation was achieved on a BEH HILIC (2.1 mm × 100 mm, 1.7 μm) column. The mobile phase was consisted of acetonitrile and 10 mm ammonium formate buffer (containing 0.1% formic acid) with gradient elution pumped at a flow rate of 0.4 mL min−1. Protein precipitation with acetonitrile was used as sample preparation. Compared with the paraquat group, there is statistical toxicokinetic difference for curcumin treatment group and pirfenidone treatment group, AUC(0 − t) decreased (P < 0.05), clearance (CL) increased (P < 0.05) for curcumin or pirfenidone treatment group, and Cmax decreased (P < 0.05) for curcumin treatment group. The results showed that treatment by curcumin and pirfenidone could relieve acute paraquat poisoning in rats.

Słowa kluczowe

Paraquat UPLC–MS/MS toxicokinetics rat curcumin pirfenidone

Wydawca

University of Silesia in Katowice
Akademiai Kiado

Czasopismo

Acta Chromatographica

Rocznik

2018

Tom

Vol. 30, no. 1

Strony

26--30

Opis fizyczny

Bibliogr. 33 poz., rys., tab.

Twórcy

autor

Wang S.

Laboratory of Clinical Pharmacy, The People's Hospital of Lishui, Lishui 323000, China

autor

Lin Z.

Analytical and Testing Center, Wenzhou Medical University, Wenzhou 325035, China

autor

Su K.

Analytical and Testing Center, Wenzhou Medical University, Wenzhou 325035, China

autor

Zhang J.

Analytical and Testing Center, Wenzhou Medical University, Wenzhou 325035, China

autor

Zhang L.

Analytical and Testing Center, Wenzhou Medical University, Wenzhou 325035, China

autor

Gao Z.

College of Plant Protection, Anhui Agricultural University, Hefei 230036, China
The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, 325000, China

autor

Ma J.

Analytical and Testing Center, Wenzhou Medical University, Wenzhou 325035, China

autor

Wang X.

lankywang@163.com

Analytical and Testing Center, Wenzhou Medical University, Wenzhou 325035, China

Bibliografia

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Uwagi

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).

Typ dokumentu

Bibliografia

Identyfikator YADDA

bwmeta1.element.baztech-13793737-d38a-4caa-aa5a-ad528b29b129