Effect of collagen fibres and elastic lamellae content on the mechanical behaviour of abdominal aortic aneurysms

• Autorzy: Kobielarz Magdalena

Identyfikatory

DOI

10.37190/ABB-01580-2020-02

• Języki publikacji: EN

Abstrakty

EN

Purpose: The main purpose of this study was a detailed analysis of the mechanical and structural characteristics of human abdominal aneurysms in comparison with normal abdominal aortae and determination of the correlations between their mechanical behaviour and the microstructural content. Methods: Various mechanical properties, i.e., mechanical failure properties, elastic moduli, inflection point coordinates, index of anisotropy and incompressibility were determined under uniaxial loading conditions in the circumferential and axial directions. Constitutive parameters were derived from the commonly used constitutive model proposed by Holzapfel et al. [9]. The microstructural arrangement was examined by histological staining supported by scanning electron microscopy analysis. The content of collagen fibres and elastic lamellae was tested in relation to mechanical properties and constitutive parameters. Results: Significant differences were found in the microstructural arrangement and layer composition of the aneurysmal specimens, compared to the normal aorta group. The mechanical properties and constitutive parameters of the aneurysmal specimens were significantly altered, indicating a weakening of the load-bearing properties of the walls of the aneurysms. A comparative analysis discovered significant correlations between structural composition and mechanical parameters, in particular with respect to the number of collagen fibres and failure stress, which can be important for clinical evaluation of abdominal aortic aneurysm (AAA) rupture. Conclusions: Changes in the content of collagen fibres and elastic lamellae correlate with mechanical and constitutive parameters, indicating AAA severity

Słowa kluczowe

EN

abdominal aortic aneurysm; mechanical properties; constitutive modelling; uniaxial tensile loading; collagen fibres; elastic lamellae

PL

tętniak aorty brzusznej; właściwości mechaniczne; modelowanie konstytutywne; jednoosiowe obciążenie rozciągające; włókna kolagenowe; elastyczne lamele

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Acta of Bioengineering and Biomechanics
• Rocznik: 2020
• Tom: Vol. 22, no. 3
• Strony: 9--21
• Opis fizyczny: Bibliogr. 31 poz., fot., tab., wykr.

Twórcy

autor

Kobielarz Magdalena

• Department of Mechanics, Materials and Biomedical Engineering, Faculty of Mechanical Engineering, Wrocław University of Science and Technology, ul. Łukasiewicza 7/9, 50-371 Wrocław, Poland

Bibliografia

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