Stability-indicating high-performance thin-layer chromatographic method for analysis of terbinafine in pharmaceutical formulations

• Autorzy: Ahmad S. , Jain G. K. , Faiyazuddin Md. , Iqbal Z. , Talegaonkar S. , Sultana Y. , Ahmad F. J.
• Języki publikacji: EN

Abstrakty

EN

A new, simple, selective, precise, robust and stability-indicating high-performance thin-layer chromatographic (HPTLC) method has been established for analysis of terbinafine hydrochloride (TH) in the bulk drug and in pharmaceutical formulations. Separation was achieved on aluminium plates precoated with silica gel 60F 254 , with toluene-ethyl acetate-formic acid 4.5:5.5:0.1 ( v/v ) as mobile phase. Densitometric analysis was performed at 284 nm. Compact bands of TH were obtained at R F 0.31 ± 0.02. Linearity ( r 2 = 0.9985), limit of quantification (35 ng per band), recovery (97.6−101.6%), and precision (≤2.19) were satisfactory. The method was applicable for routine analysis and accelerated stability testing of TH in pharmaceutical drug-delivery systems. Because the method can effectively separate the drug from its degradation products, it can be used as a stability-indicating method.

Słowa kluczowe

EN

terbinafine; high-performance thin-layer chromatography; degradation; stability

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2009
• Tom: Vol. 21, no. 4
• Strony: 631--639
• Opis fizyczny: Bibliogr. 9 poz., rys., tab.

Twórcy

autor

Ahmad S.

• Hamdard University Department of Pharmaceutics, Faculty of Pharmacy Hamdard Nagar New Delhi 110062 India

autor

Jain G. K.

• Hamdard University Department of Pharmaceutics, Faculty of Pharmacy Hamdard Nagar New Delhi 110062 India

autor

Faiyazuddin Md.

• Hamdard University Department of Pharmaceutics, Faculty of Pharmacy Hamdard Nagar New Delhi 110062 India

autor

Iqbal Z.

• Hamdard University Department of Pharmaceutics, Faculty of Pharmacy Hamdard Nagar New Delhi 110062 India

autor

Talegaonkar S.

• Hamdard University Department of Pharmaceutics, Faculty of Pharmacy Hamdard Nagar New Delhi 110062 India

autor

Sultana Y.

• Hamdard University Department of Pharmaceutics, Faculty of Pharmacy Hamdard Nagar New Delhi 110062 India

autor

Ahmad F. J.

• Hamdard University Department of Pharmaceutics, Faculty of Pharmacy Hamdard Nagar New Delhi 110062 India

Bibliografia

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