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Deuterium isotope effects in oxidation of dopamine by tyramine oxidase

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
We report the studies on the mechanism of oxidation of dopamine (DA) to 3’,4’-dihydroxyphenylacetaldehyde (DOPAL) by enzyme tyramine oxidase (EC 1.4.3.6) using kinetic isotope effects (KIE) and solvent isotope effects (SIE) methods. For kinetic studies, the selectively deuterium labelled isotopologues of dopamine, i.e., [(1R)-2H]-, and [(1S)- -2H]-DA were used. The numerical values of KIE’s for the (1R)- and (1S)-isotopologues of dopamine in the enzymatic oxidation of DA to DOPAL were determined using the non competitive spectrophotometric method. Also, the SIE’s for this reaction carried out in heavy water were obtained spectrophotometrically. Some mechanistic details of enzymatic oxidation of DA to DOPAL were discussed.
Czasopismo
Rocznik
Strony
255--259
Opis fizyczny
Bibliogr. 29 poz., rys.
Twórcy
autor
  • Department of Chemistry, University of Warsaw, 1 L. Pasteur Str., 02-093 Warsaw, Poland, Tel.: +48 22 822 0211 ext. 509, Fax: +48 22 822 0211 ext. 434
autor
  • Department of Chemistry, University of Warsaw, 1 L. Pasteur Str., 02-093 Warsaw, Poland, Tel.: +48 22 822 0211 ext. 509, Fax: +48 22 822 0211 ext. 434
autor
  • Department of Chemistry, University of Warsaw, 1 L. Pasteur Str., 02-093 Warsaw, Poland, Tel.: +48 22 822 0211 ext. 509, Fax: +48 22 822 0211 ext. 434
Bibliografia
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  • 4. Burke WJ, Li SW, Williams EA, Nonneman R, Zahm DS (2003) 3,4-Dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo: implications for Parkinson’s disease pathogenesis. Brain Res 989:205–213
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  • 14. Li SW, Lin TS, Minteer S, Burke WJ (2001) 3,4-Dihydroxyphenylacetaldehyde and hydrogen peroxide generate a hydroxyl radical: possible role in Parkinson’s disease pathogenesis. Mol Brain Res 93:1–7
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  • 19. Pająk M, Kańska M (2006) Synthesis of isotopomers of dopamine labeled with deuterium or tritium. J Labelled Compd Radiopharm 49:1061–1067
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Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-12cb312c-9b69-4012-b8d4-1d5fecf78c63
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