Apparatus for exposure of cancer cell lines with extremely low frequency (ELF) alternating magnetic field

• Autorzy: Mydlikowski Remigiusz , Maniak Krzysztof , Grosman-Dziewiszek Patrycja , Wiatrak Benita , Bieńkowski Paweł , Gębarowski Tomasz

Identyfikatory

DOI

10.24425/bpasts.2025.153429

• Języki publikacji: EN

Abstrakty

EN

This paper presents the design of a laboratory stand that facilitates the study of the effects of exposure to magnetic induction of extremely low frequency on cultures of cancer cell lines. The designed laboratory bench is adapted to operate in the frequency range of up to 300 Hz and the maximum settable magnetic induction of 2.5 mT. Tests are conducted on cellular test plates of 24, 48, or 96 wells where it is possible to evaluate the combined effect of magnetic field and cisplatin on cancer cells. The conducted tests determined the uniformity of field distribution inside the constructed solenoid establishing the optimal space for cellular research. Preliminary studies of the effect of the magnetic field on the response of cancer cells treated with cisplatin were conducted on the built stand. The study shows that a magnetic field with certain parameters can significantly affect the response of cancer cells to cisplatin treatment. The application of a magnetic field can either promote cell proliferation or, with appropriately selected parameters, lead to increased cytotoxicity. Continued research will allow us to find the appropriate drug concentration parameters when using magnetic field exposure with given parameters.

Słowa kluczowe

EN

alternating magnetic field; extremely low frequencies; cancer cells; cell viability; cisplatin

PL

zmienne pole magnetyczne; ekstremalnie niskie częstotliwości; komórki nowotworowe; żywotność komórek; cisplatyna

• Wydawca: Polska Akademia Nauk, Wydział IV Nauk Technicznych
• Czasopismo: Bulletin of the Polish Academy of Sciences. Technical Sciences
• Rocznik: 2025
• Tom: Vol. 73, nr 3
• Strony: art. no. e153429
• Opis fizyczny: Bibliogr. 34 poz., fot., rys., wykr.

Twórcy

autor

Mydlikowski Remigiusz

• Faculty of Electronics, Photonics and Microsystems, Wroclaw University of Science and Technology, Wrocław, Poland

• https://orcid.org/0000-0002-8670-2913

autor

Maniak Krzysztof

• National Institute of Telecommunications, Warsaw, Poland

• https://orcid.org/0000-0003-1974-909X

autor

Grosman-Dziewiszek Patrycja

• Department of Pharmacology, Faculty of Medicine, Wroclaw Medical University, Wrocław, Poland

• https://orcid.org/0000-0001-7362-6571

autor

Wiatrak Benita

• Department of Pharmacology, Faculty of Medicine, Wroclaw Medical University, Wrocław, Poland

autor

Bieńkowski Paweł

• Department of Telecommunications and ICT, Wroclaw University of Science and Technology, Wrocław, Poland

autor

Gębarowski Tomasz

• Department of Animal Physiology and Biostructure, Wrocław University of Environmental and Life Sciences, Wrocław, Poland

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa nr POPUL/SP/0154/2024/02 w ramach programu "Społeczna odpowiedzialność nauki II" - moduł: Popularyzacja nauki (2025).