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The aim of this work is to analyse Maximum Admissible Concentration (MAC) values proposed for irritants by the Group of Experts for Chemical Agents in Poland, based on the RD50 value. In 1994–2004, MAC values for irritants based on the RD50 value were set for 17 chemicals. For the purpose of the analysis, 1/10 RD50, 1/100 RD50 and the MAC/RD50 ratio were calculated. The determined MAC values are within the 0.01–0.09 RD50 range. The RD50 value is a good rough criterion to set MAC values for irritants and it makes it possible to estimate quickly admissible exposure levels. It has become clear that, in some cases, simple setting the MAC value for an irritant at the level of 0.03 RD50 may be insufficient to determine precisely the possible hazard to workers’ health. Other available toxicological data, such as NOAEL (No-Observed-Adverse-Effect Level) and LOAEL (Lowest-Observed-Adverse-Effect Level), should always be considered as well.
Wydawca
Rocznik
Tom
Strony
95--99
Opis fizyczny
Bibliogr. 17 poz., tab.
Twórcy
autor
- Department of Scientific Information, Nofer Institute of Occupational Medicine, Łódź, Poland
autor
- Department of Scientific Information, Nofer Institute of Occupational Medicine, Łódź, Poland
autor
- Department of Scientific Information, Nofer Institute of Occupational Medicine, Łódź, Poland
Bibliografia
- 1.Czerczak S. The principles of establishing MAC values of harmful chemical compounds in the working environment. PiMOŚP. 2004;4(42):5–18. In Polish, with an abstract in English.
- 2.Alarie Y. Bioassay for evaluating the potency of airborne sensory irritants and predicting acceptable levels of exposure in man. Food Cosmet Toxicol. 1981;19:623–6.
- 3.Alarie Y. Establishing threshold limit values for airborne sensory irritants from an animal model and the mechanism of olfaction of sensory irritants. Adv Environ Toxicol. 1984;8:153–164.
- 4.Steinhagen WH, Barrow CS. Sensory irritation structure-activity study of inhaled aldehydes in B6C3F1 and Swiss-Webster mice. Toxicol Appl Pharmacol. 1984;72(3):495–503.
- 5.Tepper JS, Jackson MC, McGee JK, Costa DL, Graham JA. Estimation of respiratory irritancy from inhaled methyl tertiary-butyl ether in mice. Inhal Toxicol. 1994;6(6): 563–9.
- 6.Gagnaire F. Nasal irritation and pulmonary toxicity of aliphatic amines in mice. J Appl Toxicol. 1989;9:301–4.
- 7.Bos P. Evaluation of the sensory irritation test for the assessment of occupational health risk. Crit Rev Toxicol. 1992;21(6):423–50.
- 8.Muller J, Greff G. Recherche de relations entre toxicite de molecules d’interet industriel et properties physicochimiques: test d’irritation des voies aeriennes superieures appliques a quattre familles chimiques. Food Chem Toxicol. 1984;22:661–4.
- 9.De Ceaurriz J, Micillino JC. Quantitative evaluation of sensory irritating and neurobehavioural properties of aliphatic ketones in mice. Food Chem Toxicol. 1984;22(7):545–9.
- 10.Schaper M. Development of a database for sensory irritants and its use in establishing occupational exposure limits. Am Ind Hyg Assoc J. 1993;54:488–544.
- 11.Korsak Z, Rydzyński K. Effects of acute combined inhalation to n-butyl alcohol and n-butyl acetate in experimental animals. Int J Occup Med Environ Health. 1994;7(3):273–80.
- 12.Nielsen GD, Vinggaard AM. Sensory irritation and pulmonary irritation of C3-C7 n-alkylamines: mechanisms of receptor activation. Pharmacol Toxicol. 1988;63(4):293–304.
- 13.Piotrowski J, Szymańska J. p-Benzoquinone. Documentation of occupational exposure limits. PiMOŚP. 2000;4(26):23–34. In Polish, with an abstract in English.
- 14.Group of Experts for Chemical Agents (GECA). [Unpublisheed data from meetings]. Łódź, Poland: Nofer Institute of Occupational Medicine; 1994–2004. In Polish.
- 15.Bevan C, Neeper-Bradley TL, Tyl RW, Fisher LC, Panson RD, Kneiss JJ, et al. Two-generation reproductive toxicity study of methyl tertiary-butyl ether (MTBE) in rats [abstract]. J Appl Toxicol. 1997;17Suppl. 1:S13–9.
- 16.Puchalska H, Zapór L. Isobutyraldehyd. Documentation of occupational exposure limits. PiMOŚP. 2000;4(26):87–97. In Polish, with an abstract in English.
- 17.Sapota A. Ligocka D. 2,6-Diisobutyl ketone. Documentation of occupational exposure limits. PiMOŚP. 2000;23(1):115–226. In Polish, with an abstract in English.
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Bibliografia
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