Preparation of silver core nanoparticles with polysaccharide shell

• Autorzy: Wasiak I. , Ciach T.
• Języki publikacji: EN

Abstrakty

EN

The objective of the present study was to obtain silver core nanoparticles coated with dextran shell. In the described method dextran plays role of reductive and protective agent and also functionalisation ligand. Our research was aimed at nanoparticles synthesis at 37°C. It is the human body temperature, which is safe for temperature-sensitive drugs (proteins). In the presented work the time of reaction, dextran molecular weight and its chemical functionalisation was investigated. Particles were characterized by Nanosight and SEM, their UV–Vis spectroscopic absorption properties were also determined. Nanoparticles with diameter less than 95 nm with relatively narrow size distribution were obtained. Our work demonstrated that it was possible to obtain nanoparticles in 37°C without using any harmful reagents.

Słowa kluczowe

EN

silver nanoparticles; dextran; polyaldehydodextran

• Wydawca: Foundation for Young Scientists
• Czasopismo: Challenges of Modern Technology
• Rocznik: 2012
• Tom: Vol. 3, no. 2
• Strony: 15--17
• Opis fizyczny: Bibliogr. 8 poz., tab., rys., wykr.

Twórcy

autor

Wasiak I.

• Biomedical Engineering Laboratory, Warsaw University of Technology, Faculty of Chemical Engineering

autor

Ciach T.

Bibliografia

• [1] Kim, D.S., Y.J. Jung and Y.M Kim. “Synthesis and Properties of Dextran-Linked Ampicillin A”. Drug Development and Industrial Pharmacy 27 (2001): 97–101.
• [2] Yura, H., et al. ”Synthesis and pharmacokinetics of a novel macromolecular prodrug of Tacrolimus (FK506), FK506-dextran conjugate.” Journal of Controlled Release 57 (1999): 87–99.
• [3] Battersby, J., et al. “Sustained release of recombinant human growth hormone from dextran via hydrolysis of an imine bond.” Journal of Controlled Release 42 (1996): 143–156.
• [4] Nichifor, M., V. Coessens and E.H. Schacht. “Macromolecular prodrugs of 5-fl uorouracil — 1: Synthesis and hydrolytic stability.” Journal of Bioactive and Compatible Polymers 10 (1995) :199–222.
• [5] Ma, Ying, et al. “One-step Synthesis of Amino-dextran--protected Gold and Silver Nanoparticles and Its Aplication in Biosensores.” Analytical and Bioanalytical Chemistry 382 (2005): 1044–1048.
• [6] Jeanes, Allene and C.A. Wilham. “Periodate Oxidation of Dextran.” Journal of American Chemical Society 72 (1950): 2655–2657.
• [7] Zhao, Huiru, and Ned D. Heindel. “Determination of Degree of Substitution of Formyl groups in Polyaldehyde Dextran by the Hydroxylamine Hydrochloride Method.” Pharmaceutical Resarch 8 (1991): 400–402.
• [8] Solmon, Sally D., et al. “Synthesis and Study of Silver Nanoparticles.” Journal of Chemical Education 84 (2007): 322–325.