Development of correction techniques for the J-PET scanner

• Autorzy: Das Manish , Bayerlein Reimund , Sharma Sushil , Parzych Szymon , Niedzwiecki Szymon , Badawi Ramsey D. , Beyene Ermias Yitayew , Chug Neha , Curceanu Catalina , Czerwiński Eryk , Eliyan Kavya V. , Głowa Bogusław , Hubalewska-Dydejczyk Alicja , Kacprzak Krzysztof , Kaplanoglu Tevfik , Kasperska Kamila , Korcyl Grzegorz , Khreptak Aleksander , Kubat Karol , Kumar Deepak , Lisowski Edward , Lisowski Filip , Mędrala-Sowa Justyna , Moyo Simbarashe , Mryka Wiktor , Opalińska Marta , Pandey Piyush , Rädler Martin , Skurzok Magdalena , Sowa-Staszczak Anna , Spencer Benjamin A. , Tanty Pooja , Ardebili Keyvan Tayefi , Venadan Anoop K. , Perez del Rio Elena , Stępień Ewa Ł. , Moskal Paweł

Identyfikatory

DOI

10.5604/01.3001.0054.9362

• Języki publikacji: EN

Abstrakty

EN

Objective: Positron emission tomography (PET) is a widely used medical imaging technique that allows for non-invasive imaging of metabolic processes. However, traditional PET scanners rely on costly inorganic scintillators that limit their accessibility, especially in light of emerging long axial field-of-view devices. The modular J-PET scanner, an innovative alternative, uses 50-cm-long plastic scintillator strips, offering a cost-effective and modular solution. In this study we develop and assess the PET data correction techniques required for quantitative image reconstruction. Methods: We present methods for attenuation correction, random coincidence correction using the delayed time window (DTW) technique and scatter correction based on Monte Carlo simulations. Phantom studies using the NEMA IQ phantom were performed to qualitatively evaluate these corrections. Results: The results demonstrate that our implemented corrections for attenuation and random and scattered coincidences successfully improve the uniformity of tracer distribution in homogenous volumes and significantly reduce undesired activity in cold regions. Despite limitations in sensitivity and axial resolution, the applied correction techniques effectively enhance image quality, providing promising results for future applications. Conclusions: These findings highlight the potential of the modular J-PET system to offer affordable PET imaging and to pave the way for a total-body PET scanner based on plastic scintillators. Future work will focus on quantitative validation and the implementation of these corrections for human subject imaging.

Słowa kluczowe

EN

positron emission tomography; PET; data correction; nuclear medicine imaging; plastic scintillator; J-PET; large AFOV

• Wydawca: Uniwersytet Jagielloński - Collegium Medicum ; Index Copernicus Sp. z o.o.
• Czasopismo: Bio-Algorithms and Med-Systems
• Rocznik: 2024
• Tom: Vol. 20, no. 1
• Strony: 101--110
• Opis fizyczny: Bibliogr. 29 poz., rys.

Twórcy

autor

Das Manish

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków; Łojasiewicza str. 11, 30-348 Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0009-0001-2901-1745

autor

Bayerlein Reimund

• Department of Radiology, University of California Davis, Sacramento, California, United States
• Department of Biomedical Engineering, University of California Davis, Davis, California, United States

• https://orcid.org/0000-0002-5493-7355

autor

Sharma Sushil

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0000-0001-8947-0110

autor

Parzych Szymon

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

autor

Niedzwiecki Szymon

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0000-0002-5953-9479

autor

Badawi Ramsey D.

• Department of Radiology, University of California Davis, Sacramento, California, United States
• Department of Biomedical Engineering, University of California Davis, Davis, California, United States

• https://orcid.org/0000-0002-9769-0292

autor

Beyene Ermias Yitayew

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0009-0002-8757-2169

autor

Chug Neha

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0000-0002-6496-0866

autor

Curceanu Catalina

• INFN, Laboratori Nazionali di Frascati, Frascati, Italy

• https://orcid.org/0000-0002-1990-0127

autor

Czerwiński Eryk

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0000-0002-5076-3175

autor

Eliyan Kavya V.

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0000-0003-1636-3706

autor

Głowa Bogusław

• Chair and Department of Endocrinology, Jagiellonian University Medical College, Kraków, Poland

autor

Hubalewska-Dydejczyk Alicja

• Chair and Department of Endocrinology, Jagiellonian University Medical College, Kraków, Poland

• https://orcid.org/0000-0001-5208-4689

autor

Kacprzak Krzysztof

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0000-0001-6105-4449

autor

Kaplanoglu Tevfik

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0000-0002-9404-8501

autor

Kasperska Kamila

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

autor

Korcyl Grzegorz

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0000-0001-6244-7287

autor

Khreptak Aleksander

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0000-0002-9482-9770

autor

Kubat Karol

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0000-0003-1121-4445

autor

Kumar Deepak

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0000-0002-5577-8931

autor

Lisowski Edward

• Cracow University of Technology, Kraków, Poland

• https://orcid.org/0000-0002-7437-7391

autor

Lisowski Filip

• Cracow University of Technology, Kraków, Poland

• https://orcid.org/0000-0002-3494-1875

autor

Mędrala-Sowa Justyna

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0000-0002-1936-5515

autor

Moyo Simbarashe

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

autor

Mryka Wiktor

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0009-0006-7616-8290

autor

Opalińska Marta

• Chair and Department of Endocrinology, Jagiellonian University Medical College, Kraków, Poland

autor

Pandey Piyush

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0009-0009-9823-2435

autor

Rädler Martin

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0000-0003-3313-2993

autor

Skurzok Magdalena

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0000-0002-4794-5154

autor

Sowa-Staszczak Anna

• Chair and Department of Endocrinology, Jagiellonian University Medical College, Kraków, Poland

• https://orcid.org/0000-0001-7558-7780

autor

Spencer Benjamin A.

• Department of Radiology, University of California Davis, Sacramento, California, United States

autor

Tanty Pooja

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0009-0008-7376-9650

autor

Ardebili Keyvan Tayefi

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0000-0001-8764-1588

autor

Venadan Anoop K.

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

autor

Perez del Rio Elena

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0000-0001-7761-4084

autor

Stępień Ewa Ł.

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0000-0003-3589-1715

autor

Moskal Paweł

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Center for Theranostics, Jagiellonian University, Kraków, Poland

• https://orcid.org/0000-0002-4229-3548

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