PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
Tytuł artykułu

Simultaneous determination of ginkgolide A, B, C, bilobalide and rutin in rat plasma by LC-MS/MS and its application to a pharmacokinetic study

Identyfikatory
Języki publikacji
EN
Abstrakty
EN
A reliable LC-MS/MS method for the determination of five bioactive constituents (bilobalide, BLL; ginkgolide A, GLA; ginkgolide B, GLB; ginkgolide C, GLC; rutin) of Ginkgo biloba leaf extracts (GBE) in rat plasma was established, fully validated and applied to an intragastric pharmacokinetic study of a preparation of GBE in rat. Samples were extracted with ethyl acetate. C18 column was selected as analytical column in this method. Mobile phase was water with 0.01% formic acid and acetonitrile. Quantification was performed in negative multiple-reaction monitoring mode. Matrix instability of terpene lactones was noticed and hydrochloric acid was used as a stabilizer. This method showed good precision and accuracy, recovery was reproducible and matrix effect was negligible. Among four terpene lactones, BLL had the highest exposure and the shortest terminal half-life, GLA and GLB had lower exposure and longer terminal half-life, the exposure of GLC was lowest and its terminal half-life was the maximum, and all of them showed rapid absorption. This study provides a reference for determination of terpene lactones and flavonol glycoside prototypes in GBE and offers pharmacokinetic data of flavonol glycoside prototype in GBE.
Rocznik
Strony
386--393
Opis fizyczny
Bibliogr. 21 poz., tab., wykr.
Twórcy
autor
  • School of Pharmaceutical Sciences, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
  • Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
autor
  • School of Pharmaceutical Sciences, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
  • Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
autor
  • School of Pharmaceutical Sciences, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
  • Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
autor
  • School of Pharmaceutical Sciences, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
  • Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
  • School of Pharmaceutical Sciences, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
  • Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
autor
  • School of Pharmaceutical Sciences, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
  • Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
autor
  • School of Pharmaceutical Sciences, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
  • Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
autor
  • Zhejiang Jiuxu Pharmaceutical Co., Ltd., 398 Xianhuabei Street, Jinhua 321016, Zhejiang, China
  • Zhejiang Jiuxu Pharmaceutical Co., Ltd., 398 Xianhuabei Street, Jinhua 321016, Zhejiang, China
autor
  • School of Pharmaceutical Sciences, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
  • Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
Bibliografia
  • 1. Li, T.; Zhang, Y.; Tian, J.; Yang, L.; Wang, J. Am. J. Chin. Med. 2019, 47, 1057–73.
  • 2. Sun, M.; Chai, L.; Lu, F.; Zhao, Y.; Li, Q.; Cui, B.; Gao, R.; Liu, Y. Evid. Based Complement. Alternat. Med. 2018, 2018, 7571629.
  • 3. Dong, Y.; Li, H.; Dong, Q. Neurol. Res. 2020, 42, 260–6.
  • 4. Rapp, M.; Burkart, M.; Kohlmann, T.; Bohlken, J. Int. J. Clin. Pharmacol. Ther. 2018, 56, 130–3.
  • 5. Tian, J.; Liu, Y.; Chen, K. Curr. Vasc. Pharmacol. 2017, 15, 532–48.
  • 6. Z., Y. Y.; G., L. L.; S., G. M.; R., R.; T., J. Z. Drug Res. 2016, 66, 520–6.
  • 7. Wang, W. P.; Liu, N.; Kang, Q.; Du, P. P.; Lan, Y.; Zhao, B. C.; Chen, Y. Y.; Zhang, Q.; Li, H.; Zhang, Y. W.; Wu, Q. J. Zhejiang Univ. Sci. B 2014, 15, 929–39.
  • 8. Liu, X. W.; Yang, J. L.; Niu, W.; Jia, W. W.; Olaleye, O. E.; Wen, Q.; Duan, X. N.; Huang, Y. H.; Wang, F. Q.; Du, F. F.; Zhong, C. C.; Li, Y. F.; Xu, F.; Gao, Q.; Li, L.; Li, C. Acta Pharmacol. Sin. 2018, 39, 1935–46.
  • 9. Li, W.; Zhang, J.; Tse, F. L. Biomed. Chromatogr. 2011, 25, 258–77.
  • 10. Biber, A. Pharmacopsychiatry 2003, 36 Suppl 1, S32–7.
  • 11. Liu, X. G.; Wu, S. Q.; Li, P.; Yang, H. J. Pharm. Biomed. Anal. 2015, 113, 212–25.
  • 12. Chen, Z. P.; Sun, J.; Chen, H. X.; Xiao, Y. Y.; Liu, D.; Chen, J.; Cai, H.; Cai, B. C. Fitoterapia 2010, 81, 1045–52.
  • 13. Lu, Q.; Hao, M.; Wu, W.; Zhang, N.; Isaac, A. T.; Yin, J.; Zhu, X.; Du, L.; Yin, X. Acta Biochim. Pol. 2018, 65, 35–41.
  • 14. Yang, J.; Wang, A. Q.; Li, X. J.; Fan, X.; Yin, S. S.; Lan, K. J. Pharm. Biomed. Anal. 2016, 123, 147–54.
  • 15. Smith, B. P.; Vandenhende, F. R.; DeSante, K. A.; Farid, N. A.; Welch, P. A.; Callaghan, J. T.; Forgue, S. T. Pharm. Res. 2000, 17, 1278–83.
  • 16. Hummel, J.; McKendrick, S.; Brindley, C.; French, R. Pharm. Stat. 2009, 8, 38–49.
  • 17. Song, J.; Zhang, W.; Sun, J.; Xu, X.; Zhang, X.; Zhang, L.; Feng, Z.; Du, G. H. Acta Pharm. Sin. B 2015, 5, 246–53.
  • 18. Zheng, B.; Xing, G.; Bi, Y.; Yan, G.; Wang, J.; Cheng, Y.; Liu, Y.; Ashraf, M. A.; Xie, J. Saudi J. Biol. Sci. 2016, 23, 54–65.
  • 19. Wang, Q.; Huang, J.; Hu, C.; Xia, N.; Li, T.; Xia, Q. Food Funct. 2017, 8, 2512–22.
  • 20. Ahmad, M.; Sahabjada; Akhtar, J.; Hussain, A.; Badaruddeen; Arshad, M.; Mishra, A. EXCLI J. 2017, 16, 810–23.
  • 21. Ravi, G. S.; Charyulu, R. N.; Dubey, A.; Prabhu, P.; Hebbar, S.; Mathias, A. C. AAPS PharmSciTech 2018, 19, 3631–49.
Uwagi
Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).
Identyfikator YADDA
bwmeta1.element.baztech-11448236-b88f-4574-ad19-001eadd763c8