Simultaneous determination of ginkgolide A, B, C, bilobalide and rutin in rat plasma by LC-MS/MS and its application to a pharmacokinetic study

• Autorzy: Hu Bingying , Sun Yingying , Wang Min , He Zhisheng , Chen Shanshan , Qi Dake , Ge Zhen , Fan Lingling , Chen Jingfang , Wei Yang

Identyfikatory

DOI

10.1556/1326.2021.00962

• Języki publikacji: EN

Abstrakty

EN

A reliable LC-MS/MS method for the determination of five bioactive constituents (bilobalide, BLL; ginkgolide A, GLA; ginkgolide B, GLB; ginkgolide C, GLC; rutin) of Ginkgo biloba leaf extracts (GBE) in rat plasma was established, fully validated and applied to an intragastric pharmacokinetic study of a preparation of GBE in rat. Samples were extracted with ethyl acetate. C18 column was selected as analytical column in this method. Mobile phase was water with 0.01% formic acid and acetonitrile. Quantification was performed in negative multiple-reaction monitoring mode. Matrix instability of terpene lactones was noticed and hydrochloric acid was used as a stabilizer. This method showed good precision and accuracy, recovery was reproducible and matrix effect was negligible. Among four terpene lactones, BLL had the highest exposure and the shortest terminal half-life, GLA and GLB had lower exposure and longer terminal half-life, the exposure of GLC was lowest and its terminal half-life was the maximum, and all of them showed rapid absorption. This study provides a reference for determination of terpene lactones and flavonol glycoside prototypes in GBE and offers pharmacokinetic data of flavonol glycoside prototype in GBE.

Słowa kluczowe

EN

Ginkgo biloba; terpene lactones; flavonol glycosides; stabilizer; pharmacokinetic

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2022
• Tom: Vol. 34, no. 4
• Strony: 386--393
• Opis fizyczny: Bibliogr. 21 poz., tab., wykr.

Twórcy

autor

Hu Bingying

• School of Pharmaceutical Sciences, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
• Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China

autor

Sun Yingying

• School of Pharmaceutical Sciences, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
• Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China

autor

Wang Min

• School of Pharmaceutical Sciences, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
• Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China

autor

He Zhisheng

• School of Pharmaceutical Sciences, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
• Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China

autor

Chen Shanshan

• School of Pharmaceutical Sciences, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
• Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China

autor

Qi Dake

• School of Pharmaceutical Sciences, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
• Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China

autor

Ge Zhen

• School of Pharmaceutical Sciences, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
• Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China

autor

Fan Lingling

• Zhejiang Jiuxu Pharmaceutical Co., Ltd., 398 Xianhuabei Street, Jinhua 321016, Zhejiang, China

autor

Chen Jingfang

• Zhejiang Jiuxu Pharmaceutical Co., Ltd., 398 Xianhuabei Street, Jinhua 321016, Zhejiang, China

autor

Wei Yang

• School of Pharmaceutical Sciences, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China
• Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China

• https://orcid.org/0000-0001-6350-831X

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Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).