A numerical investigation into the magnetic nanoparticles hyperthermia cancer treatment injection strategies

• Autorzy: Dahaghin Ali , Emadiyanrazavi Seyedhamidreza , Salimibani Milad , Bahreinizad Hossein , Haghpanahi Mohammad , Eivazzadeh-Keihan Reza , Maleki Ali

Identyfikatory

DOI

10.1016/j.bbe.2021.04.002

• Języki publikacji: EN

Abstrakty

EN

Magnetic nanoparticles hyperthermia is a new and promising cancer treatment method. Injection strategies are one of the determining factors in the success of the treatment. This study is a numerical investigation into the injection methods of MNPs hyperthermia. In order to have a realistic tumor morphology and vascularity, a model of Lower Limb tumor was constructed from the CT images. The finite element method was used to solve the problem. This study includes fluid flow in capillaries and inside the porous tissue of the tumor, mass transfer from the capillaries into the tumor tissue, inside the tumor tissue, and from the tumor tissue into the capillaries, and finally heat transfer across the tumor. Finally, tissue damage was calculated in order to evaluate the performance of each method. Results of intravenous injection with single point intratumoral injections were compared here. The results of this study show that intravenous injection yields more homogenous MNPs concentration and temperature distribution, while MNPs concentration and temperature increase in direct injection was limited in a small area around the injection point. Results of the current research suggest that damage to tissue from the hyperthermia with intravenous injection is much more significant compared to direct injection.

Słowa kluczowe

EN

finite element method; hyperthermia; magnetic nanoparticles; cancer treatment

PL

metoda elementów skończonych; hipertermia; nanocząstka magnetyczna; leczenie nowotworu

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2021
• Tom: Vol. 41, no. 2
• Strony: 516--526
• Opis fizyczny: Bibliogr. 60 poz., rys., tab., wykr.

Twórcy

autor

Dahaghin Ali

• School of Mechanical Engineering, Iran University of Science and Technology (IUST), Tehran, Iran

autor

Emadiyanrazavi Seyedhamidreza

• Department of Biomedical Engineering, Islamic Azad University, Central Tehran Branch, Tehran, Iran

autor

Salimibani Milad

• School of Mechanical Engineering, Iran University of Science and Technology (IUST), Tehran, Iran

autor

Bahreinizad Hossein

• Department of Mechanical Engineering, Sahand University of Technology (SUT), Tabriz, Iran

autor

Haghpanahi Mohammad

• School of Mechanical Engineering, Iran University of Science and Technology (IUST), Tehran, Iran

autor

Eivazzadeh-Keihan Reza

• Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, Iran

autor

Maleki Ali

• Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, Iran

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2021).