Przegląd rodzajów chiralnych faz stacjonarnych oraz możliwości ich zastosowań w chromatografii cieczowej

Śliwka-Kaszyńska, M.; Momotko, M.; Szarmańska, J.; Boczkaj, G.; Kamiński, M.

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Tytuł artykułu

Przegląd rodzajów chiralnych faz stacjonarnych oraz możliwości ich zastosowań w chromatografii cieczowej

Autorzy

Śliwka-Kaszyńska M. , Momotko M. , Szarmańska J. , Boczkaj G. , Kamiński M.

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Warianty tytułu

Types of chiral stationary phases and its applications to liquid chromatography (LC) : a mini review

Języki publikacji

Abstrakty

Chromatograficzne rozdzielanie związków optycznie czynnych ma ogromne znaczenie nie tylko w przemyśle farmaceutycznym, ale i agrochemicznym, a także w badaniach naukowych różnego rodzaju. W niniejszym opracowaniu scharakteryzowano komercyjnie dostępne chiralne fazy stacjonarne na bazie, cyklodekstryn, polisacharydów, makrocyklicznych antybiotyków, eterów koronowych, a także fazy proteinowe, ligandowymienne, jonowymienne oraz fazy typu Pirkle’a. Omówiono podstawowe właściwości fizyczne i chemiczne w/w faz stacjonarnych, przedstawiono przykładowe ich struktury, mechanizmy chiralnego rozpoznania oraz podstawowe zastosowania. Opisano również warunki chromatograficznego rozdzielania chiralnego dla wybranych farmaceutyków i pestycydów.

Importance of chromatographic enantioseparations in the pharmaceutical and agrochemical industries is still increasing. In this paper the chiral stationary phases, including cyclodextrins, polysaccharides, macrocyclic antibiotics, crown ethers, proteins, ligand-exchange, Pirkle-type and ion exchange phases is discussed. For all types of chiral stationary phases, the basic physical and chemical properties are discussed, as well as the structure and the possible chiral recognition mechanisms. The basic applications of this phases are also described. Chromatographic conditions for chiral separation of selected active pharmaceutical ingredients and pesticides are reviewed.

Słowa kluczowe

rozdzielenie chiralne chiralne fazy stacjonarne CSP chromatografia cieczowa

chiral separation chiral stationary phase CSP liquid chromatography

Wydawca

Publishing House of Siedlce University of Natural Sciences and Humanities

Czasopismo

Camera Separatoria

Rocznik

2015

Tom

Vol. 7, No. 2

Strony

99--128

Opis fizyczny

Bibliogr. 82 poz., rys., tab.

Twórcy

autor

Śliwka-Kaszyńska M.

magkaszy@pg.gda.pl

Katedra Chemii Organicznej, Wydział Chemiczny, Politechnika Gdańska

autor

Momotko M.

Katedra Inżynierii Chemicznej i Procesowej, Wydział Chemiczny, Politechnika Gdańska

autor

Szarmańska J.

Katedra Inżynierii Chemicznej i Procesowej, Wydział Chemiczny, Politechnika Gdańska

autor

Boczkaj G.

Katedra Inżynierii Chemicznej i Procesowej, Wydział Chemiczny, Politechnika Gdańska

autor

Kamiński M.

markamin@pg.gda.pl

Katedra Inżynierii Chemicznej i Procesowej, Wydział Chemiczny, Politechnika Gdańska

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