Simultaneous determination of thimerosal and aluminum in vaccines and pharmaceuticals with the use of HPLC method

• Autorzy: Zaręba M. , Sanecki P. T. , Rawski R.
• Języki publikacji: EN

Abstrakty

EN

A simple and convenient chromatographic method of simultaneous separation, identification, and quantitative determination of thimerosal (TM) (preservative) and aluminum (adjuvant) in vaccines and pharmaceuticals by reversed phase highperformance liquid chromatography (RP-HPLC) with visible (VIS) detection was developed and validated. Due to postcolumn derivatization with dithizone, any interference from matrix was excluded. Similarly, a possibility of on-column decomposition of dithizonates was eliminated. Evaluated detection limits were 0.3 μg TM and 3.0 μg Al, which correspond to the smallest, but possible to recognize, visible peak.

Słowa kluczowe

EN

thimerosal; aluminum; HPLC; dithizone; vaccines

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2016
• Tom: Vol. 28, no. 3
• Strony: 299--311
• Opis fizyczny: Bibliogr. 64 poz., rys., tab.

Twórcy

autor

Zaręba M.

• Department of General Chemistry and Electrochemistry, Faculty of Chemistry, Rzeszow University of Technology, 35-959 Rzeszow, Poland

autor

Sanecki P. T.

• Department of General Chemistry and Electrochemistry, Faculty of Chemistry, Rzeszow University of Technology, 35-959 Rzeszow, Poland

autor

Rawski R.

• Department of General Chemistry and Electrochemistry, Faculty of Chemistry, Rzeszow University of Technology, 35-959 Rzeszow, Poland

Bibliografia

• [1] J. G. Melnick, K. Yurkerwich, D. Buccella, W. Sattler and G. Parkin, Inorg. Chem., 47, 6421 (2008)
• [2] D. A. Geier, L. K. Sykes, and M. R. Geier, J. Toxicol. Environ. Health, Part B, 10, 575 (2007)
• [3] L. Magos, J. Appl. Toxicol., 21, 1 (2001)
• [4] G. L. Freed, M. C. Andreae, A. E. Cowan, and S. L. Katz, Health Policy, 62, 291 (2002)
• [5] C. J. Clements, L. K. Ball, R. Ball, and D. Pratt, Lancet, 355, 1279 (2000)
• [6] M. Tan and J. E. Parkin, Int. J. Pharm., 208, 23 (2000)
• [7] M. J. Reader and C. B. Lines, J. Pharm. Sci., 72, 1406 (1983)
• [8] J. E. Parkin, J. Chromatogr., 542, 137 (1991)
• [9] P. Arudra, Y. Nguiffo-Podie, E. Frost, and J. J. Dubowski, J. Phys. Chem. C, 114, 13657 (2010)
• [10] M. P. da Silva, J. R. Procopio, and L. Hernández, Anal. Chim. Acta, 283, 326 (1993)
• [11] I. Suda, S. Totoki, T. Uchida, and H. Takahashi, Arch. Toxicol., 66, 40 (1992)
• [12] T. M. Burbacher, D. D. Shen, N. Liberato, K. S. Grant, E. Cernichiari, and T. Clarkson, Environ. Health Perpect., 113, 1015 (2005)
• [13] N. Imura, E. Sukegawa, S. K. Pan, K. Nagao, J. Y. Kim, T. Kwan, and T. Ukita, Science., 172, 1248 (1971)
• [14] L. Bertilsson and H. Y Neujahr, Biochemistry, 10, 2805 (1971)
• [15] H. S. Pan-Hou and N. Imura, Arch. Microbiol., 131, 176 (1982)
• [16] C. Sanfeliu, J. Sebastià, R. Cristòfol, and E. Rodriguez-Farré, Neurotoxic. Res., 5, 283 (2003)
• [17] T. W. Clarkson and L. Magos, Crit. Rev. Toxicol., 36, 609 (2006)
• [18] M. E. Pichichero, A. Gentile, N. Giglio, V. Umido, T. Clarkson, E. Cernichiari, G. Zareba, C. Gotelli, M. Gotelli, l. Yan, and J. Treanor, Pediatrics, 121, 208 (2008)
• [19] M. E. Pichichero, E. Cernichiari, J. Lopreiato, and J. Treanor, Lancet, 360, 1737 (2002)
• [20] M. R. Geier and D. A. Geier, J. Am. Phys. Surg., 8, 6 (2003)
• [21] K. Stratton, A. Gable, and M. C. McCormick, Immunization Safety Review: Thimerosal-Containing Vaccines and Neurodevelopmental Disorders, Washington, DC, National Academy Press, 2001
• [22] L. Tomljenovic and C. A. Shaw, J. Inorg. Biochem., 105, 1489 (2011)
• [23] R. K. Gupta, Adv. Drug Deliv. Rev., 32, 155 (1998)
• [24] E. B. Lindblad, Vaccine, 22, 3658 (2004)
• [25] H. HogenEsch, Vaccine, 20, S34 (2002)
• [26] S. Gil, I. Lavilla, and C. Bendicho, J. Anal. At. Spectrom., 22, 569 (2007)
• [27] V. Alexiu, E. Chirtop, L. Vladescu, and M. Simion, Acta Chim. Slov., 51, 361 (2004)
• [28] Q. Wu, Z. Zhu, Z. Liu, H. Zheng, S. Hu, and L. Li, J. Anal. At. Spectrom., 27, 496 (2012)
• [29] P. Bertocchi, E. Ciranni, D. Compagnone, V. Magearu, G. Palleschi, S. Pirvutoiu, and L. Valvo, J. Pharm. Biomed. Anal., 20, 263 (1999)
• [30] R. Shekhar, D. Karunasagar, K. Dash, and M. Ranjit, J. Anal. At. Spectrom., 25, 875 (2010)
• [31] Z. Zhu, G. C.-Y. Chan, S. J. Ray, X. Zhang, and G. M. Hieftje, Anal. Chem., 80, 7043 (2008)
• [32] H. He, Z. Zhu, H. Zheng, Q. Xiao, L. Jin, and S. Hu, Microchem. J., 104, 7 (2012)
• [33] E. J. dos Santos, A. B. Herrmann, A. B. dos Santos, L. M. Baika, C. S. Sato, L. Tormen, R. E. Sturgeon, and A. J. Curtius, J. Anal. At. Spectrom., 25, 1627 (2010)
• [34] A. Fredj, H. Okbi, N. Adhoum, and L. Monser, Talanta, 91, 47 (2012)
• [35] S. H. Kang and H. Kim, J. Pharm. Biomed. Anal., 15, 1359 (1997)
• [36] L. Costa, M. Vega, Y. Díaz, J. L. Marcelo, J. M. Hernández, and T. Martino, J. Chromatogr. A, 907, 173 (2001)
• [37] D. Tleugabulova and I. G. Pérez, J. Cromatogr. A, 729, 219 (1996)
• [38] R. C. Meyer and L. B. Cohn, J. Pharm. Sci., 67, 1636 (1978)
• [39] J. R. Procopio, M. P. da Silva, M. del Carmen Asensio, M. T. Sevilla, and L. Hernandez, Talanta, 39, 1619 (1992)
• [40] G. C. Visor, R. A. Kenley, J. S. Fleitman, D A. Neu, and I. W. Partridge, Pharm. Res., 73 (1985)
• [41] E. M. de la Fournière, M. I. Litter, and E. A. Gautier, J. Argent. Chem. Soc., 100, 1 (2013)
• [42] M. P. da Silva, J. Rodriguez, and L. Hernández, Analyst, 119, 1971 (1994)
• [43] K. P. Shrivastaw and S. Singh, Biologicals, 23, 65 (1995)
• [44] M. S. Collado, V. E. Mantovani, H. C. Goicoechea, and A. C. Olivieri, Talanta, 52, 909 (2000)
• [45] D. S. Bushee, Analyst, 113, 1167 (1988)
• [46] D. S. Bushee, J. R. Moody, and J. C. May, J. Anal. At. Spectrom., 4, 773 (1989)
• [47] M. Morita, J. Yoshinaga, and J. S. Edmonds, Pure & Appl. Chem., 70, 1585 (1998)
• [48] F. Thèraulaz and O. P. Thomas, Mikrochim. Acta, 113, 53 (1994)
• [49] C. T. Elly, Water Pollut. Control Fed., 45, 940 (1973)
• [50] R. Litman, E. T. Williams, and H. L. Finston, Anal. Chem., 49, 983 (1977)
• [51] W. Langseth, Anal. Chim. Acta, 185, 249 (1986)
• [52] O. Grummitt and R. Stickle, Ind. Eng. Chem., Anal. Ed., 14, 953 (1942)
• [53] M. M. Harding, J. Chem. Soc., 4136 (1958)
• [54] X.-D. Yao, J.-C. Liu, J.-K. Cheng, and Y. Zeng, Anal. Sci., 8, 255 (1992)
• [55] WHO, BLG/UNDP/77. 2 Rev 1, 78–79, Appendix T. 16
• [56] L. S. Meriwether, E. C. Breitner, and C. L. Sloan, J. Am. Chem. Soc., 87, 4441 (1965)
• [57] A. M. Bond and Y. Nagaosa, Anal. Chim. Acta, 178, 197 (1985)
• [58] H.-Z. Lian, Y.-F. Kang, S.-P. Bi, A. Yasin, D.-L. Shao, Y.-J. Chen, L.-M. Dai, and L.-C. Tian, Anal. Bioanal. Chem., 376, 542 (2003)
• [59] C. Y. Zhou, J. Wu, H. Chi, M. K. Wong, L. L. Koh, and Y. C. Wee, Talanta, 42, 415 (1995)
• [60] J. Czerminski, A. Iwasiewicz, Z. Paszek, A. Sikorski, Statistical Methods for Experimental Data Processing (Metody Statystyczne w Doswiadczalnictwie Chemicznym), wyd. 2 zm., 2nd edn, Polish Scientific Publishing House (PWN), Warsaw, 1974 (in Polish)
• [61] J. M. Andrade and M. P. Gomez-Carracedo, Anal. Methods, 5, 1145–1149 (2013)
• [62] L. Cuadros Rodriguez, A. M. Garcia Campana, and J. M. Bosque Sendra, Anal. Lett., 29(7), 1231–1239 (1996)
• [63] Analytical Methods Committee, Analyst, 119, 2363–2366 (1994)
• [64] J. Wei, D. Paul, StatWiki 2015, UC Davis GeoWiki by University of California, http://statwiki.ucdavis.edu/Regression_Analysis/Simple_linear_regression/Test_for_Lack_of_Fit

Uwagi

PL

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę.