Degradation of hydroxychloroquine in aqueous solutions under electron beam treatment

• Autorzy: Kabasa Stephen , Sun Yongxia , Bułka Sylwester , Chmielewski Andrzej G.

Identyfikatory

DOI

10.2478/nuka-2024-0009

• Konferencja: International Conference on Development and Applications of Nuclear Technologies NUTECH 2023 (22-24 September 2023 ; Krakow, Poland)
• Języki publikacji: EN

Abstrakty

EN

Hydroxychloroquine (HCQ), a 4-amino quinoline derivative, has antimalarial and anti-inflammatory activity and was most recently proposed in the treatment of SARS-COVID-19. Its pharmacokinetics and toxic side effects necessitate the monitoring of its presence in the environment and its removal from wastewater. In this study, HCQ was removed from an aqueous solution with a removal efficiency of between 80% and 90% under electron beam (EB) irradiation. The degradation of HCQ was propagated by reactions involving both the hydroxyl radical and aqueous electron. The degradation was observed to follow a pseudo-first-order kinetic reaction. The applied radiation dose, pH, and initial HCQ concentration were influential in the degradation efficiency under EB irradiation. Acidic and alkaline pH favored the removal of HCQ under EB irradiation. Even though the initial HCQ was successfully degraded, it was not completely mineralized. The TOC and chemical oxygen demand (COD) remained at a relatively stable level following EB irradiation of the aqueous solutions. This is attributed to the formation of other organic compounds that were not degraded under the investigated experimental conditions.

Słowa kluczowe

EN

advanced oxidation process; aqueous solutions; degradation; electron beam; hydroxychloroquine

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2024
• Tom: Vol. 69, No. 2
• Strony: 65--74
• Opis fizyczny: Bibliogr. 41 poz., rys.

Twórcy

autor

Kabasa Stephen

• Institute of Nuclear Chemistry and Technology Dorodna 16 St., 03-195 Warsaw, Poland

• https://orcid.org/0000-0002-0039-9205

autor

Sun Yongxia

• Institute of Nuclear Chemistry and Technology Dorodna 16 St., 03-195 Warsaw, Poland

• https://orcid.org/0000-0002-7359-3869

autor

Bułka Sylwester

• Institute of Nuclear Chemistry and Technology Dorodna 16 St., 03-195 Warsaw, Poland

• https://orcid.org/0000-0002-0377-1535

autor

Chmielewski Andrzej G.

• Institute of Nuclear Chemistry and Technology Dorodna 16 St., 03-195 Warsaw, Poland

• https://orcid.org/0000-0001-6262-5952

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa nr POPUL/SP/0154/2024/02 w ramach programu "Społeczna odpowiedzialność nauki II" - moduł: Popularyzacja nauki (2025).