Dialysis therapies: Investigation of transport and regulatory processes using mathematical modelling

• Autorzy: Pstras Leszek , Stachowska-Pietka Joanna , Debowska Malgorzata , Pietribiasi Mauro , Poleszczuk Jan , Waniewski Jacek

Identyfikatory

DOI

10.1016/j.bbe.2021.12.002

• Języki publikacji: EN

Abstrakty

EN

Haemodialysis (HD) and peritoneal dialysis (PD) are the main kidney replacement therapies for patients with end-stage renal disease. Both of these life-sustaining therapies replace the key functions of the failing kidneys, i.e. the removal of the excess body water and waste products of metabolism as well as the restoration of fluid-electrolyte and acid-base balance. The dialysis-induced multi-scale transport and regulatory processes are complex and difficult to analyse or predict without the use of mathematical and computational models. Here, following a brief introduction to renal replacement therapies, we present an overview of the most important aspects and challenges of HD and PD, indicating the types and examples of mathematical models that are used to study or optimize these therapies. We discuss various compartmental models used for the study of intra- and interdialytic fluid and solute kinetics as well as distributed models of water and solute transport taking place across the peritoneal tissue or in the dialyzer. We also discuss models related to blood volume changes and cardiovascular stability during HD, including models of the thermal balance, likely related to intradialytic hypotension. A short overview of models of acid-base equilibration during HD and mineral metabolism in dialysis patients is also provided, along with a brief outline of models related to blood flow in arteriovenous fistulas and cardiovascular adaptations following the fistula creation. Finally, we discuss the model-based methods of assessment of dialysis adequacy in both HD and PD.

Słowa kluczowe

EN

renal replacement therapy; haemodialysis; peritoneal dialysis; compartmental modelling; lumped parameter model; distributed model; dialysis adequacy

PL

leczenie nerkozastępcze; hemodializa; dializa otrzewnowa; model o parametrach skupionych; model rozproszony

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2022
• Tom: Vol. 42, no. 1
• Strony: 60--78
• Opis fizyczny: Bibliogr. 242 poz., rys., tab., wykr.

Twórcy

autor

Pstras Leszek

• Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Ks. Trojdena 4, 02-109 Warsaw, Poland

autor

Stachowska-Pietka Joanna

• Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland

autor

Debowska Malgorzata

• Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland

autor

Pietribiasi Mauro

• Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland

autor

Poleszczuk Jan

• Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland

autor

Waniewski Jacek

• Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland

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