Tytuł artykułu
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Abstrakty
Qualitative and quantitative analysis was performed on supercritical-fluid and conventional Soxhlet extracts of Betula pendula Roth., Alnus glutinosa (L.) Gaertn., and Platanus hybrida Brot. bark. The effect of the two extraction methods on extraction yields was compared. Lupeol and β-sitosterol were identified in the bark extracts by TLC and by GC-MS. The main components were betulin and lupeol followed by β-sitosterol; betulinic acid seemed to be a minor constituent. Betulin content was determined by RP-HPLC, with acetonitrile-water 80:20 ( v/v ) as mobile phase. Comparison of the extraction methods showed that supercritical-fluid (scCO 2 + EtOH) and ethanolic Soxhlet extraction resulted in the highest extraction yields. Accumulation of betulin derivatives was higher in supercritical-fluid extracts (scCO 2 + EtOH) than in conventional Soxhlet extracts.
Słowa kluczowe
Czasopismo
Rocznik
Tom
Strony
671--681
Opis fizyczny
Bibliogr. 23 poz., rys., tab.
Twórcy
autor
- Semmelweis University Department of Pharmacognosy Üllői út 26 1085 Budapest Hungary
- Gedeon Richter Plc Gyömrői út 19-21 1103 Budapest Hungary
autor
- Budapest University of Technology and Economics Department of Chemical and Environmental Process Engineering Műegyetem rkp. 3 1111 Budapest Hungary
autor
- Budapest University of Technology and Economics Department of Chemical and Environmental Process Engineering Műegyetem rkp. 3 1111 Budapest Hungary
autor
- Semmelweis University Department of Pharmacognosy Üllői út 26 1085 Budapest Hungary
autor
- Semmelweis University Department of Pharmacognosy Üllői út 26 1085 Budapest Hungary
autor
- Semmelweis University Department of Pharmacognosy Üllői út 26 1085 Budapest Hungary
Bibliografia
- [1] C. Gauthier, J. Legault, M. Lebrun, P. Dufour, and A. Pichette, Bioorg. Med. Chem., 14 , 6713 (2006)
- [2] Y. Gong, K.M. Raj, C.A. Luscombe, I. Gadawski, T. Tam, J. Chu, D. Gibson, R. Carlson, and S.L. Sacks, Antiviral Res., 64 , 127 (2004)
- [3] S. Alakurtti, T. Mäkelä, S. Koskimies, and J. Yli-Kauhaluoma, Eur. J. Pharm. Sci., 29 , 1 (2006)
- [4] K. Yamashita, H. Lu, J. Lu, G. Chen, T. Yokoyama, Y. Sagara, M. Manabe, and H. Kodama, Clin. Chim. Acta, 325 , 91 (2002)
- [5] L. Vidya and P. Varalakhsmi, Fitoterapia, 71 , 535 (2000)
- [6] T. Geetha and P. Varalakhsmi, J. Ethnopharmacol., 76 , 77 (2001)
- [7] I. Patočka, J. Appl. Biomed., 1 , 7 (2003)
- [8] C. Mutaia, D. Abatisa, C. Vagiasa, D. Moreauc, C. Roussakisc, and V. Roussisa, Phytochemistry, 65 , 1159 (2004)
- [9] V. Castola, A. Bighelli, S. Rezzi, G. Melloni, S. Gladiali, J.M. Desjobert, and J. Casanova, J. Ind. Crops Products, 15 , 15 (2002)
- [10] C.C.F. Simo, S.F. Kouam, H.M.P. Poumale, I.K. Simo, B.T. Ngadjui, I.R. Green, and K. Krohn, Biochem. Systematics Ecol., 36 , 238 (2008)
- [11] K.P. Chaturvedi, K. Bhui, and Y. Shukla, Cancer Lett., 263 , 1 (2008)
- [12] S.C. Pînzaru, N. Leopold, and W. Kiefer, Talanta, 57 , 625 (2002)
- [13] G. Zhao, W. Yan, and D. Cao, J. Pharm. Biomed. Anal., 43 , 959 (2007)
- [14] J.M. Lavoie and T. Stevanovic, Phytochem. Anal., 18 , 291 (2007)
- [15] H. Pakdel, J.N. Murwanashyaka, and C. Roy, J. Wood Chem. Technol., 22 , 155 (2002)
- [16] S. Badami, M.K. Gupta, S. Ramaswamy, S.R. Rai, M. Nanjaian, D.J. Bendell, R. Subban, and S. Bhojaraj, J. Sep. Sci., 27 , 129 (2004)
- [17] B.H.D.E. Olivera, C.A.M. Santos, and A.P. Espindola, Phytochem. Anal., 13 , 95 (2002)
- [18] T. Galgon, D. Höke, and B. Dräger, Phytochem. Anal., 10 , 187 (1999)
- [19] G. Romanik, E. Gilgenast, A. Przyjazny, and M. Kamiński, J. Biochem. Biophys. Methods, 70 , 253 (2007)
- [20] W.K. Modey, D.A. Mulholland, and M.W. Raynor, Phytochem. Anal., 7 , 1 (1996)
- [21] M. Hamburger, S. Adler, D. Baumann, A. Förg, and B. Weinreich, Fitoterapia, 74 , 328 (2003)
- [22] V. Sewram, M.W. Raynor, D.A. Mulholland, and D.M. Raidoo, J. Pharm. Biomed. Anal., 24 , 133 (2000)
- [23] E. Rónyai, B. Simándi, S. Tömösközi, A. Deák, L. Vigh, and Zs. Weinbrenner, J. Supercrit. Fluids, 14 , 75, (1998)
Typ dokumentu
Bibliografia
Identyfikator YADDA
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