Hemostatic, Resorbable Dressing of Natural Polymers-Hemoguard

• Autorzy: Wiśniewska-Wrona M. , Kucharska M. , Struszczyk M. H. , Cichecka M. , Wilbik-Hałgas B. , Szymonowicz M. , Paluch D. , Guzińska K. , Rybak Z.

Identyfikatory

DOI

10.1515/aut-2015-0051

• Języki publikacji: EN

Abstrakty

EN

Investigations are presented for the preparation of a model hemostatic dressing that would exhibit an adequate hemostatic capacity in injuries and surgical wounds, an antibacterial activity to prevent primary and secondary infections, and offer safety in use. The Hemoguard dressing has been designed as a powder prepared from the complex chitosan/alginate Na/Ca in the form of micro- and nano-fibrids. Useful antibacterial and hemostatic properties of Hemoguard, which would qualify the material as first aid dressing and a temporary protection of injury wounds in field conditions, were assessed. Biocompatibility of the dressing was confirmed by biological in vitro examinations.

Słowa kluczowe

EN

hemostatic properties; chitosan-alginate; microfibrids; nanofibrids; antibacterial activity

PL

właściwości hemostatyczne; chitozan/alginian Na/Ca; mikrofibrydy; nanofibrydy; aktywność antybakteryjna

• Wydawca: Lodz University of Technology, Faculty of Material Technologies and Textile Design
• Czasopismo: Autex Research Journal
• Rocznik: 2016
• Tom: Vol. 16, no. 1
• Strony: 29--34
• Opis fizyczny: Bibliogr. 21 poz.

Twórcy

autor

Wiśniewska-Wrona M.

• Institute of Biopolymers and Chemical Fibres, ul. M. Skłodowskiej-Curie 19/27, 90-570 Łódź

autor

Kucharska M.

• Institute of Biopolymers and Chemical Fibres, ul. M. Skłodowskiej-Curie 19/27, 90-570 Łódź

autor

Struszczyk M. H.

• Institute of Security Technologies „MORATEX”, ul. M. Skłodowskiej-Curie 3, 90-965 Łódź

autor

Cichecka M.

• Institute of Security Technologies „MORATEX”, ul. M. Skłodowskiej-Curie 3, 90-965 Łódź

autor

Wilbik-Hałgas B.

• Institute of Security Technologies „MORATEX”, ul. M. Skłodowskiej-Curie 3, 90-965 Łódź

autor

Szymonowicz M.

• Department of Experimental Surgery and Biomaterials Research, Wroclaw Medical University, ul. Poniatowskiego 2, 50-326 Wrocław

autor

Paluch D.

• Department of Experimental Surgery and Biomaterials Research, Wroclaw Medical University, ul. Poniatowskiego 2, 50-326 Wrocław

autor

Guzińska K.

• Institute of Biopolymers and Chemical Fibres, ul. M. Skłodowskiej-Curie 19/27, 90-570 Łódź

autor

Rybak Z.

• Department of Experimental Surgery and Biomaterials Research, Wroclaw Medical University, ul. Poniatowskiego 2, 50-326 Wrocław

Bibliografia

• [1] Niekraszewicz A., Lebioda J., Kucharska M., Wesołowska E.; „Research into Developing Antibacterial Dressing Materials”, Fibres & Textiles in Eastern Europe, vol.15, No 1(60), (2007)
• [2] Kucharska M., Niekraszewicz A., Lebioda J., Brzoza-Malczewska K., Wesołowska E., „Bioactive Composite Materials” monograph, vol. XII edited by M. Jaworska „Progress on Chemistry and Application of Chitin and Its Derivatives”, p.131-138, Polish Chitin Society, (2007)
• [3] Niekraszewicz A., Kucharska M., Wawro D., Struszczyk M. H., Rogaczewska A.: “Development of a Manufacturing Method for Surgical Meshes Modified by Chitosan”, Fibres & Textiles in Eastern Europe, vol.15, No 3(62), (2007)
• [4] Niekraszewicz A., Kucharska M., Wiśniewska-Wrona M., Kardas I.: „Biological and Physicochemical Study of the Implantation of a Modified Polyester Vascular Prosthesis”, Fibres & Textiles in Eastern Europe, vol. 18, No 6 (83), p. 100-105, (2010)
• [5] Niekraszewicz A., Kucharska M., Kardas I., Wiśniewska-Wrona M., Kustosz R., Jarosz A.: „Chitosan Coatings to Seal Cardiovascular Prostheses”, Fibres & Textiles in Eastern Europe, vol. 19, No 3 (86), p. 106-111, (2011)
• [6] Kucharska M., Ciechańska D., Niekraszewicz A., Wiśniewska–Wrona M., Kardas I.: “Potential use of chitosan–based materials in medicine”, „Progress on chemistry and application of chitin and its derivatives”, periodical, vol. XV, ed by M. Jaworska, Polish Chitin Society, Łódź, p.169-176, (2010)
• [7] Wiśniewska-Wrona M., Kucharska M., Kardas I., Bodek A., Bodek K. H.: „ Polymer biocomposites used in bedsores treatment” „Progress on chemistry and application of chitin and its derivatives”, periodical, vol. XVI, ed. by M. Jaworska, Polish Chitin Society, Łódź, p.111-120, (2011)
• [8] Kucharska M., Niekraszewicz A., Kardas I., Marcol W., Właszczuk A., Larysz-Brysz M., Lewin – Kowalik J.: “Developing a Model of Peripheral Nerve Graft Based on Natural Polymers”, Fibres & Textiles in Eastern Europe, vol. 20, No 6B (96), p. 115-120, (2012)
• [9] Kucharska M., Struszczyk M. H., Cichecka M., Brzoza-Malczewska K., Wiśniewska-Wrona M.: “Prototypes of Primary Wound Dressing of fibrous and Quasi_fibrous Structure in Terms of Safety of Their Usage”, Fibres & Textiles in Eastern Europe, vol. 20, No 6B (96), p. 142-148, (2012)
• [10] Wiśniewska-Wrona M., Niekraszewicz A., Struszczyk H.,. Guzińska G; „Estimation of Polymer Compositions Containing Chitosan for Veterinary Applications”, Fibres & Textiles in Eastern Europe, vol.10, No 3(38), (2002)
• [11] PL 214 380 B1 (2008)
• [12] PL 214 380 B1 (2008)
• [13] PN-EN ISO 13726-1: 2005, Methods for the direct testing of wounds. Part 1: Aspects concerning absorption.
• [14] PN-EN ISO 13726-2:2005, Methods for the direct testing of wounds. Part 2: Transmission of moisture through the dressing with a semi-permeable film” for model dressing.
• [15] Procedure PB 1, Examination of antibacterial action of textile products. Quantitative test” prepared on base of JISL 1902:2002.
• [16] ASTM, F 756 – 00, 2008, Standard practice for assessment of hemolytic properties of materials.
• [17] PN EN ISO 10993-4: 2009, Biological evaluation of medical devices. Part 4: Selection of tests for interactions with blood.
• [18] Szymonowicz M., Fraczek-Szczypta A., Rybak Z., Blazewicz S.: „Comparative assessment of the effect of carbon-based material surfaces on blood clotting activation and haemolysis”. Diamond & Related Materials, 2013, Vol. 40, 89-95.
• [19] Szymonowicz M., Pielka S., Owczarek A, Haznar D., Pluta J.: “Study on influence of gelatin-alginate matrixes on the coagulation system and morphotic blood elements.” Macromolecular Symposia, 2007, Vol. 253, 71-76.
• [20] Gadelha de Carvalho M.M.S., Montenegro Stamford T. C., Pereira dos Santos E., Tenório and F.Sampaio P.: “Chitosan as an oral antimicrobial agent”, Formatex 2011.
• [21] Yadav AV, Bhise .B.:” Chitosan: a potential biomaterial effective against typhoid.” Cur. Sci.87(9): 1176-1178, (2004).

Uwagi

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę.