Development of innovative biopolymers designed for bone regeneration applications and in vitro study of their biocompatibility and osteogenic capacity on human bone marrow mesenchymal stem cells

• Autorzy: Basile M. S. , Gomez d'Ayala G. , Laurienzo P. , Malinconico M. , Oliva A.
• Języki publikacji: EN

Abstrakty

EN

In the frame of a project aiming to the improvement of the properties of biodegradable polyester-based devices, designed for bone regeneration, we have prepared and characterized novel composites based on poly(ε-caprolactone) (PCL). In particular, we report in this paper the functional changes made through radical grafting on PCL to obtain the less hydrophobic derivatives, PCL-MA-GMA [maleic anhydride (MA)-glycidylmethacrylate (GMA)] and PCL-DMAEA [N-(dimethyl-amino)ethylacrylate]. In addition, we studied in vitro the biocompatibility and the osteogenic capacity of these novel polyesters on human bone marrow (BM) mesenchymal stem cells (MSC).

Słowa kluczowe

EN

functionalization of poly(ε-caprolactone); bone marrow mesenchymal stem cells

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2012
• Tom: Vol. 15, no. 113
• Strony: 13--15
• Opis fizyczny: Bibliogr. 4 poz., rys., wykr.

Twórcy

autor

Basile M. S.

• Department of Biochemistry and Biophysics, Second University of Naples, Via De Crecchio 7, 80138 Naples, Italy

autor

Gomez d'Ayala G.

• Institute of Chemistry and Technology of Polymers, Via Campi Flegrei 34, 80078 Pozzuoli, Italy

autor

Laurienzo P.

• Institute of Chemistry and Technology of Polymers, Via Campi Flegrei 34, 80078 Pozzuoli, Italy

autor

Malinconico M.

• Institute of Chemistry and Technology of Polymers, Via Campi Flegrei 34, 80078 Pozzuoli, Italy

autor

Oliva A.

• Department of Biochemistry and Biophysics, Second University of Naples, Via De Crecchio 7, 80138 Naples, Italy

Bibliografia

• [1] Gomez d'Ayala G., Di Pace E., Laurienzo P., Pantalena D., Somma E., Nobile M.R.: Poly(E-caprolactone) modified by functional groups: Preparation and chemical-physical investigation. Europ Polymer J 45 (2009) 3217-29.
• [2] Laurienzo P., Malinconico M., Mattia G., Romano G.: Synthesis and characterization of functionalised crosslinkable poly(ε-caprolactone). Macromol Chem Phys 207 (2006) 1861-69.
• [3] Oliva A., Passaro I., Di Pasquale R., Di Feo A., Criscuolo M., Zappia V., et al.: Ex vivo expansion of bone marrow stromal cells by platelet-rich plasma: a promising strategy in maxillo-facial surgery. Int J of Immunopathol and Pharmacol 18 (2005) 47-53.
• [4] Annunziata M., Oliva A., Basile M.A., Giordano M., Mazzola N., Rizzo A., Lanza A., Guida L.: The effects of titanium nitride-coating on the topographic and biological features of TPS implant surfaces. J Dentistry 39 (2011) 720-728.