In vitro investigation of anti-inflammatory activity of propolis/saffron extract/curcumin-loaded ZIF8 nanoparticles and their potential application for treating osteoarthritis

• Autorzy: Zhang Hongtao , Xu Kui , Zhao Zhen , Dong Chuan , Zhang Yunfei

Identyfikatory

DOI

10.2478/msp-2024-0016

• Języki publikacji: EN

Abstrakty

EN

Background: Osteoarthritis (OA) poses a significant healthcare challenge globally, necessitating the development of effective therapeutic interventions. It is crucial to develop novel drug delivery systems for OA treatment. Aims: This study explores the potential of propolis, saffron extract, and curcumin-loaded zeolitic imidazolate framework-8 (ZIF8) nanoparticles as a treatment modality for OA. The anti-inflammatory and chondroprotective properties of these natural compounds make them promising candidates for OA management. Methods: Through comprehensive in vitro investigations, including scanning electron microscopy (SEM), MTT assays, antiinflammatory assays, cell migration assays, Fourier transform infrared (FTIR) spectroscopy, and release assays, we evaluated the physicochemical and biological characteristics of propolis, saffron extract, and curcumin-loaded ZIF8 nanocarriers. Results: Our Endings demonstrate that these nanocarriers effectively encapsulated the bioactive compounds, exhibited sustained release profiles, and displayed significant anti-inflammatory properties. Notably, propolis-loaded ZIF8 nanocarriers exhibited superior anti-inflammatory activity compared to other formulations. The encapsulation of propolis, saffron extract, and curcumin within ZIF8 nanoparticles holds promise for enhancing their therapeutic efficacy and ensuring targeted delivery to affected joints in OA treatment. Conclusion: This study highlights the potential of nanotechnology-based delivery systems in harnessing the therapeutic benefits of natural compounds for OA management.

Słowa kluczowe

EN

osteoarthritis; zeolitic imidazolate framework; nanoparticles; drug delivery; propolis; sajfron extract; curcumin

• Wydawca: De Gruyter
• Czasopismo: Materials Science Poland
• Rocznik: 2024
• Tom: Vol. 42, No. 2
• Strony: 41--51
• Opis fizyczny: Bibliogr. 28 poz., rys.

Twórcy

autor

Zhang Hongtao

• Department of Orthopedics, Tangdu Hospital, The Air Force Medical University, Xi’an, Shaanxi,China, 710038

autor

Xu Kui

• Department of Orthopedics, Tangdu Hospital, The Air Force Medical University, Xi’an, Shaanxi,China, 710038

autor

Zhao Zhen

• Department of Orthopedics, Tangdu Hospital, The Air Force Medical University, Xi’an, Shaanxi,China, 710038

autor

Dong Chuan

• Department of Orthopedics, Tangdu Hospital, The Air Force Medical University, Xi’an, Shaanxi,China, 710038

autor

Zhang Yunfei

• Department of Orthopedics, Tangdu Hospital, The Air Force Medical University, Xi’an, Shaanxi,China, 710038

Bibliografia

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