Response of Lyapunov exponents to diffusion state of biological networks

• Autorzy: Altuntas Volkan , Gok Murat , Kocal Osman Hilmi

Identyfikatory

DOI

10.34768/amcs-2020-0051

• Języki publikacji: EN

Abstrakty

EN

The topologies of protein-protein interaction networks are uncertain and noisy. The network topology determines the reliability of computational knowledge acquired from noisy networks and can impose the deterministic and non-deterministic character of the resulting data. In this study, we analyze the effect of the network topology on Lyapunov exponents and its relationship with network stability. We define the methodology to convert the network data into signal data and obtain the Lyapunov exponents for a variety of networks. We then compare the Lyapunov exponent response and the stability results. Our technique can be applied to all types of network topologies as demonstrated with our experiments, conducted on both synthetic and real networks from public databases. For the first time, this article presents findings where Lyapunov exponents are evaluated under topological mutations and used for network analysis. Experimental results show that Lyapunov exponents have a strong correlation with network stability and both are correlatively affected by the network model. Hence we develop a novel coefficient, termed LEC, to measure the robustness of biological networks. LEC can be applied to real or synthetic biological networks rapidly. Results are a striking indication that the Lyapunov exponent is a potential candidate measure for network analysis.

Słowa kluczowe

EN

synthetic network; biological network; Lyapunov exponents

PL

sieć syntetyczna; sieć biologiczna; wykładniki Lapunova

• Wydawca: Oficyna Wydawnicza Uniwersytetu Zielonogórskiego
• Czasopismo: International Journal of Applied Mathematics and Computer Science
• Rocznik: 2020
• Tom: Vol. 30, no. 4
• Strony: 689--702
• Opis fizyczny: Bibliogr. 46 poz., rys., tab., wykr.

Twórcy

autor

Altuntas Volkan

• Department of Information Technologies, Bursa Technical University, Bursa, 16310, Turkey

autor

Gok Murat

• Department of Computer Engineering, Yalova University, Yalova, 77200, Turkey

autor

Kocal Osman Hilmi

• Department of Computer Engineering, Yalova University, Yalova, 77200, Turkey

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