Simultaneous determination of anthraquinone derivatives in Radix et Rhizoma Rhei-based medicines by ultra-performance LC-ESCI-MS/MS multiple reaction monitoring

• Autorzy: Wang G. Y. , Shi Y. P.
• Języki publikacji: EN

Abstrakty

EN

A new method using ultra-performance liquid chromatography (UPLC) in combination with tandem mass spectrometry and a multiple reaction monitoring mode (UPLC-MS/MS-MRM) was developed for simultaneous quantitative determination of anthraquinone derivatives in Radix et Rhizoma Rhei-based medicines. A multi-mode electrospray/chemical ionization (ESCI) and negative ion mode with [M-H]− and its fragments under collision-activated conditions were employed in MS/MS-MRM. The quantitative method was validated and applied to simultaneous determination of anthraquinone derivatives in 21 Radix et Rhizoma Rhei-based medicines. The limits of quantification were in the range of 3.90–9.09 ng mL ^-1. Average recoveries were between 95.5% and 99.8% with relative standard deviations from 1.8% to 5.3%.

Słowa kluczowe

EN

ultra-performance LC; tandem mass spectrometry; multiple reaction monitoring; anthraquinone derivatives; Radix et Rhizoma Rhei-based medicines

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2014
• Tom: Vol. 26, no. 2
• Strony: 229--242
• Opis fizyczny: Bibliogr. 18 poz., rys., tab.

Twórcy

autor

Wang G. Y.

• Chinese Academy of Sciences Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics Lanzhou 730000 P. R. China

autor

Shi Y. P.

• Lanzhou University of Technology School of Petroleum and Chemical Engineering Lanzhou 730050 P. R. China

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