Electron beam sterilization of implantable rods with risperidone and with 17-β-estradiol: a structural, thermal and morphology study

• Autorzy: Wilińska Justyna , Turek Artur , Borecka Aleksandra , Rech Jakub , Kasperczyk Janusz

Identyfikatory

DOI

10.5277/ABB-01399-2019-01

• Języki publikacji: EN

Abstrakty

EN

Poly(L-lactide-co-glycolide-co-trimethylene carbonate) rods with risperidone and 17-β-estradiol were sterilized by electron beam irradiation. The aim of the study was to assess electron beam irradiation impact on terpolymer composition, chain microstructure, glass transition temperature, molecular weight and the morphological features of rods. Methods: Hot melt extrusion in the formulation of rods was applied. Sterilization of the rods was performed by electron beam in an electron beam accelerator (10 MeV, 360 mA, 25 kGy). The following methods in the development of rods were applied: nuclear magnetic resonance, differential scanning calorimetry, gel permeation chromatography and scanning electron microscopy. Results: Sterilization influenced only glass transition temperature in blind rods and rods with risperidone. As for the other parameters, no significant changes were observed as far as a sterilization effect is concerned. However, some changes were noted after introducing drug substances and after extrusion. Conclusions: Electron beam irradiation of rods with risperidone and rods with 17-β-estradiol is an adequate method for sterilizing implantable drug delivery systems.

Słowa kluczowe

EN

electron beam sterilization; implantable rods; poly(L-lactide-co-glycolide-co-trimethylene carbonate); risperidone; 17-β-estradiol

PL

sterylizacja wiązką elektronów; 17β-estradiol; rysperydon

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Acta of Bioengineering and Biomechanics
• Rocznik: 2019
• Tom: Vol. 21, no. 3
• Strony: 39--47
• Opis fizyczny: Bibliogr. 30 poz., rys., tab., wykr.

Twórcy

autor

Wilińska Justyna

• School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Chair and Department of Biopharmacy, Sosnowiec, Poland

autor

Turek Artur

• School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Chair and Department of Biopharmacy, Sosnowiec, Poland

autor

Borecka Aleksandra

• Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland

autor

Rech Jakub

• School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Chair and Department of Biopharmacy, Sosnowiec, Poland

autor

Kasperczyk Janusz

• School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Chair and Department of Biopharmacy, Sosnowiec, Poland
• Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).