Estimation of radial artery reactive response using high frequency ultrasound

• Autorzy: Nowicki A. , Secomski W. , Trawiński Z. , Lewandowski M. , Trots I. , Szubielski M. , Olszewski R.
• Języki publikacji: EN

Abstrakty

EN

Background: There is a growing interest in the application of non-invasive clinical tools allowing one to assess the endothelial function, preceding atherosclerosis. The precision in estimating of the artery Flow Mediated Vasodilation (FMD) using standard 10-12 MHz linear array probes does not exceed 0.2 mm, far beyond that required. Methods: We have introduced a wide-band, high frequency 25-30 MHz, Golay encoded wobbling type imaging to measure dilation of the radial artery instead of the brachial one. 18 young volunteers, and 4 volunteers with cardiac events history, were examined. In the second approach 20 MHz linear scanning combined with 20 MHz pulsed Doppler attached to the linear array was used. The radial artery FMD was normalized using shear rate at the radial artery wall. Results and Conclusions: For the “healthy” group, the FMD resulting from reactive hyperemia response was over 20%; while in the “atherosclerotic” group, the FMD was at least twice as small, not exceeding 10%. The shear rate (SR) normalized FMDSR was in the range from 7.8 to 9.9 in arbitrary units, while in patients with minor cardiac history FMDSR was clearly lower, 6.8 to 7.6. The normalized FMDSR of radial artery RARR can be an alternative to the brachial FMD where the precision of measurements is lower and the diameter dilation does not exceed 7-10%.

Słowa kluczowe

EN

thick film transducers; atherosclerosis; flow mediated vasodilation

• Wydawca: Polskie Towarzystwo Akustyczne. Oddział Gdański
• Czasopismo: Hydroacoustics
• Rocznik: 2016
• Tom: Vol. 19
• Strony: 297--306
• Opis fizyczny: Bibliogr. 11 poz., rys.

Twórcy

autor

Nowicki A.

• Department of Ultrasound, Institute of the Fundamental Technological Research

autor

Secomski W.

• Department of Ultrasound, Institute of the Fundamental Technological Research

autor

Trawiński Z.

• Department of Ultrasound, Institute of the Fundamental Technological Research

autor

Lewandowski M.

• Department of Ultrasound, Institute of the Fundamental Technological Research

autor

Trots I.

• Department of Ultrasound, Institute of the Fundamental Technological Research

autor

Szubielski M.

• Mazowiecki Szpital Wojewódzki , Siedlce, Poland

autor

Olszewski R.

• Institute of the Fundamental Technological Research Polish Academy of Sciences, Warsaw, Poland

Bibliografia

• [1] Black M.A., Cable N.T., Thijssen D.H,. Green D.J.. Importance of Measuring the Time Course of Flow-Mediated Dilatation in Humans, Hypertension, 51, 203–210, 2008.
• [2] Celermajer D.S., Sorensen K.E., Gooch V.M., et al., Non-invasive Detection of Endothelial Dysfunction in Children And Adults at Risk of Atherosclerosis, Lancet, 340, pp.1111–1115, 1992.
• [3] Corretti M.C. Anderson T.J., Benjamin E.J., Celermajer D., et al, Guidelines for the Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery: a Report of the International Brachial Artery Reactivity Task Force, J. Am.Coll.Cardiol 39, pp.257–265, 2002.
• [4] Harris R.A. and J Padilla J., Proper ''Normalization'' of Flow-Mediated Dilation for Shear, J.Appl.Physiol, 103, 1108, 2007.
• [5] Harris R.A., Nishiyama S.K., Richardson D.W., Ultrasound Assessment of FlowMediated Dilation, Hypertension, 5, 1075-1085, 2010.
• [6] Lewandowski M., Nowicki A., High Frequency Coded Imaging System with RF Software Signal Processing, IEEE Trans. Ultrason., Ferroelect., Freq. Control, 55, 8, 2008.
• [7] Mitchell G.F., Parise H., Vita J.A., Larson M.G., Warner E. et al., Local Shear Stress and Brachial Artery Flow-Mediated Dilation: the Framingham Heart Study, Hypertension 44, 134–139, 2004.
• [8] Nowicki A., Lewandowski M., Wójcik J., Tymiewicz R., Lou-Moller R., Wolny W., Zawada T., Thick Film Transducers for High Frequency Coded Ultrasonography, Archives of Acoustics, 36,(4), pp.945–954, 2011.
• [9] Nowicki A., Trots, I., P. Lewin P., Secomski W., Tymkiewicz R., Influence of the ultrasound transducer bandwidth on selection of the complementary Golay bit code length, Ultrasonics, vol. 47, 2007, pp. 64 – 73, 2007.
• [10] Pyke K.E. and Tschakovsky M E. Peak vs. total reactive hyperemia: which determines the magnitude of flow-mediated dilation, J.Appl.Physiol, 102:1510 -1519, 2007.
• [11] Pyke K.E., Dwyer E.M., Tschakovsky M E,. Impact of controlling shear rate on flowmediated dilation responses in the brachial artery of humans, J.Appl.Physiol 97: 499– 508, 2004.

Uwagi

PL

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę (zadania 2017)