Polymeric drug carriers—Control of the daily dose and therapy duration

• Autorzy: Trusek-Holownia A. , Jaworska P.

Identyfikatory

DOI

10.1016/j.bbe.2014.11.001

• Języki publikacji: EN

Abstrakty

EN

This study evaluates the mass release of cyanocobalamin with various drug carriers. Monolithic structures with a liquid core covering a thick (>150 μm) porous, polymer membrane are recommended. Membrane pore size should ensure easy diffusion of the drug molecules. The selection of the carrier's parameters to fit a required daily dose and therapy duration must consider the following criteria: 1′ the determination of its size (geometric surface); 2′ the number of carriers, if more than one is necessary; 3′ the thickness of membrane covering the carrier; and 4′ the mass of the loading drug. An algorithm to select these conjugated parameters to achieve the therapeutic threshold and duration of the drug effect was expanded upon. A system to constantly deliver drugs over days/weeks/months can be maintained if the loaded mass of the drug significantly exceeds its solubility in the carrier's core.

Słowa kluczowe

EN

drug reservoir; diffusion; controlled release; membrane parameter; algorithm

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2015
• Tom: Vol. 35, no. 3
• Strony: 192--197
• Opis fizyczny: Bibliogr. 13 poz., rys., tab., wykr.

Twórcy

autor

Trusek-Holownia A.

• Wroclaw University of Technology, Department of Chemistry, Norwida 4/6, 50-373 Wroclaw, Poland

autor

Jaworska P.

• Wroclaw University of Technology, Department of Chemistry, Norwida 4/6, 50-373 Wroclaw, Poland

Bibliografia

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