The effect of hyperbaric exposure on vascular endothelium’s capability of nitric oxide synthesis

• Autorzy: Kozakiewicz M. , Kaczerska D. , Ciesielska N.

Identyfikatory

DOI

10.13006/phr.45.1

Warianty tytułu

PL

Wpływ ekspozycji hiperbarycznej na zdolność śródbłonka naczyń do syntezy tlenku azotu

• Języki publikacji: PL EN

Abstrakty

PL

Praca przedstawia alalię wpływu ekspozycji hiperbarycznych na zdolność śródbłonka naczyń do syntezy tlenku azotu wyrażoną jako pomiar stężenia azotanów/azotynów w surowicy ochotników poddanych ekspozycji hiperbarycznej. Dodatkowo oceniano za pomocą pomiaru stężenia całkowitego stężenia ponadtlenków jaki wpływ na pojemność antyoksydacyjną ma przebywanie w hiperbarii. Wyniki: Zaobserwowano istotnie wyższe stężenie azotanów/azotynów po ekspozycji hiperbarycznej. Podobnie zaobserwowano podwyższone stężenie całkowitego stężenia nadtlenków w badanej grupie. Wnioski: Uzyskane wyniki pokazują, że przebywanie w środowisku hiperbarycznym nie jest obojętne dla komórek śródbłonka. Otwartym pozostaje jednak problem jaki czas i na jakie warunki ciśnieniowe pozostaje bezpieczny.

EN

The paper presents an aphonia of the effects of hyperbaric exposures on endothelial capability to generate nitric oxide synthesis, expressed as a measurement of the concentration of nitrates/nitrites in the blood serum of volunteers subjected to a hyperbaric exposure. In addition the method of measurement of total concentration of superoxides was used to assess the impact of antioxidant capacity while being subjected to hyperbaric oxygenation. Results: A significantly higher concentration of nitrates/nitrites was observed following a hyperbaric exposure. Similarly, an increased concentration of total superoxides in the researched groups was observed. Conclusions: The obtained results indicate that staying in a hyperbaric environment is not insignificant for endothelial cells. However, the issue that stays open is the one concerning the time and the pressure conditions in which the exposure remains safe.

Słowa kluczowe

PL

tlenek azotu; śródbłonek; hiperbaria

EN

nitric oxide; endothelium; hyperbaric oxygenation

• Wydawca: Polskie Towarzystwo Medycyny i Techniki Hiperbarycznej
• Czasopismo: Polish Hyperbaric Research
• Rocznik: 2013
• Tom: nr 4(45)
• Strony: 7--18
• Opis fizyczny: Bibliogr. 36 poz.

Twórcy

autor

Kozakiewicz M.

• Katedra i Zakład Biochemii Uniwersytet Mikołaja Kopernika w Toruniu

autor

Kaczerska D.

• Zakład Dietetyki Ogólnej, Katedra Żywienia Klinicznego, Gdański Uniwersytet Medyczny

autor

Ciesielska N.

• Katedra i Klinika Geriatrii Uniwersytet Mikołaja Kopernika Collegium Medicum w Bydgoszczy

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