GTV volume estimation using different mode of computer tomography for lung tumors in stereotactic body radiation therapy

• Autorzy: Lingaiah Ramaa , Ali Md Abbas , Kulsum Ummay , Muneem Muhtasim Aziz , Mani Karthick Raj , Ahmed Sharif , Rahman Md. Shakilur , Salahuddin M.

Identyfikatory

DOI

10.2478/pjmpe-2019-0005

• Języki publikacji: EN

Abstrakty

EN

Aim: To estimate the Gross Tumor Volume (GTV) using different modes (axial, helical, slow, KV-CBCT & 4D-CT) of computed tomography (CT) in pulmonary tumors. Materials & Methods: We have retrospectively included ten previously treated case of carcinoma of primary lung or metastatic lung using Stereotactic Body Radiation Therapy (SBRT) in this study. All the patients underwent 4 modes of CT scan Axial, Helical, Slow & 4D-CT using GE discovery 16 Slice PET-CT scanner and daily KV-CBCT for the daily treatment verification. For standardization, all the patients underwent different modes of scan using 2.5 mm slice thickness, 16 detectors rows and field of view of 400mm. Slow CT was performed using axial mode scan by increasing the CT tube rotation time (typically 3 – 4 sec.) as per the breathing period of the patients. 4D-CT scans were performed and the entire respiratory cycle was divided into ten phases. Maximum Intensity Projections (MIP), Minimum Intensity Projections (MinIP) and Average Intensity Projections (AvIP) were derived from the 10 phases. GTV volumes were delineated for all the patients in all the scanning modes (GTV_AX - Axial, GTV_HL - Helical, GTV_SL – Slow, GTV_MIP -4DCT and GTV_CB – KV-CBCT) in the Eclipse treatment planning system version 11.0 (M/S Varian Medical System, USA). GTV volumes were measured, documented and compared with the different modes of CT scans. Results: The mean ± standard deviation (range) for MIP, slow, axial, helical & CBCT were 36.5 ± 40.5 (2.29 – 87.0), 35.38 ± 39.52 (2.1 – 82), 31.95 ± 37.29 (1.32 – 66.9), 28.98 ± 33.36 (1.01 – 65.9) & 37.16 ± 42.23 (2.29 – 92). Overall underestimation of helical scan and axial scan compared to MIP is 21% and 12.5%. CBCT and slow CT volume has a good correlation with the MIP volume. Conclusion: For SBRT in lung tumors better to avoid axial and helical scan for target delineation. MIP is a still a golden standard for the ITV delineation, but in the absence of 4DCT scanner, Slow CT and KV-CBCT data may be considered for ITV delineation with caution.

Słowa kluczowe

EN

GTV; SBRT; CT; delineation

• Wydawca: Polskie Towarzystwo Fizyki Medycznej ; De Gruyter
• Czasopismo: Polish Journal of Medical Physics and Engineering
• Rocznik: 2019
• Tom: Vol. 25, Iss. 1
• Strony: 29--34
• Opis fizyczny: Bibliogr. 7poz., rys., tab.

Twórcy

autor

Lingaiah Ramaa

• Department of Physics, Jahangirnagar University, 1342, Dhaka, Bangladesh

autor

Ali Md Abbas

• Department of Medical Physics and Biomedical Engineering, Dhaka, Bangladesh

autor

Kulsum Ummay

• Department of Medical Physics and Biomedical Engineering, Dhaka, Bangladesh

autor

Muneem Muhtasim Aziz

• Department of Radiation Oncology, Dhaka, Bangladesh

autor

Mani Karthick Raj

• Department of Radiation Oncology, Dhaka, Bangladesh

autor

Ahmed Sharif

• Department of Radiation Oncology, Dhaka, Bangladesh

autor

Rahman Md. Shakilur

• Secondary Standard Dosimetry Laboratory, Institute of Nuclear Science and Technology, Bangladesh Atomic Energy Commission, Dhaka, Bangladesh

autor

Salahuddin M.

• Department of Physics, Jahangirnagar University, 1342, Dhaka, Bangladesh

Bibliografia

• [1] Segedin B, Petric P. Uncertainties in target volume delineation in radiotherapy – are they relevant and what can we do about them? Radiol Oncol. 2016;50(3):254-262.
• [2] International Commission on Radiation Units and Measurements Report 62: Prescribing, Recording, and Reporting Photon Beam Therapy (Supplement to ICRU Report 50) Bethesda, MD: ICRU; 1999.
• [3] Shang DP, Liu CX, Yin Y. A comparison of the different 3D CT scanning modes on the GTV delineation for the solitary pulmonary lesion. Radiat Oncol. 2014;9:211.
• [4] Li F, Li J, Zhang Y, et al. Geometrical differences in gross target volumes between 3DCT and 4DCT imaging in radiotherapy for non-small-cell lung cancer. J Radiat Res. 2013;54(5): 950-956.
• [5] Wang W, Ki J, Zhang Y, et al. Comparison of patient-specific internal gross tumor volume for radiation treatment of primary esophageal cancer based separately on three-dimensional and four-dimensional computed tomography images. Dis Esophagus. 2014;27(4):348-354.
• [6] Park S, Urm S, Cho H. Analysis of Biologically Equivalent Dose of Stereotactic Body Radiotherapy for Primary and Metastatic Lung Tumors. Cancer Res Treat. 2014;46(4):403-410.
• [7] Peng J, Zhang Z, Wang J, et al. Is internal target volume accurate for dose evaluation in lung cancer stereotactic body radiotherapy? Oncotarget. 2016;7(16):22523-22530.

Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).