Robust Identification Approach to Individualized Anemia Model

• Autorzy: Akabua E. , Inanc T. , Gaweda A. , Brier M. E. , Kim S. , Zurada J. M.
• Języki publikacji: EN

Abstrakty

EN

Over ninety percent of End Stage Renal Disease (ESRD) patients suffer from anemia due to insufficient endogenous production of human erythropoietin. Until the advent of Recombinant Human Erythropoietin (r-HuEPO) over 30 years ago, patients with ESRD were treated mainly with multiple blood transfusions. The high cost of r-HuEPO in addition to the narrow margin between an effective do-sage and toxicity in drug administration calls for optimal dosage strategy capable of minimizing cost and toxicity while at the same time achieving the desired do-sage outcome. It is well known from control theory that a controller can be de-signed for any plant provided there is readily available a valid model for such a plant. We present Robust Identification procedure, a dimensionality reduction technique capable of capturing the inherent dynamics of anemia patients; conse-quently producing individualized model suitable for robust control synthesis and any other controller design methodologies.

Słowa kluczowe

EN

hemoglobin; robust identification; Carathéodory-Fejér problem; erythropoeitin; anemia management

• Wydawca: Społeczna Akademia Nauk w Łodzi
• Czasopismo: Journal of Applied Computer Science Methods
• Rocznik: 2011
• Tom: Vol. 3 No. 2
• Strony: 65--75
• Opis fizyczny: Bibliogr. 14 poz., rys.

Twórcy

autor

Akabua E.

• Department of Electrical Engineering, University of Louisville, Louisville, KY. 40292

autor

Inanc T.

• Department of Electrical Engineering, University of Louisville, Louisville, KY. 40292

autor

Gaweda A.

• Division of Nephrology, University of Louisville, Louisville, KY. 40292

autor

Brier M. E.

• Division of Nephrology, University of Louisville, Louisville, KY. 40292
• Department of Veteran Affairs, Louisville, KY. 40292

autor

Kim S.

• Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY. 40292

autor

Zurada J. M.

• Department of Electrical Engineering, University of Louisville, Louisville, KY. 40292

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