Mechanical unfolding of Ddfln4 studied by coarse-grained knowledge-based cabs model

• Autorzy: Kouza M. , Jamroz M. , Gront D. , Kmiecik S. , Koliński A.
• Języki publikacji: EN

Abstrakty

EN

Mechanical unfolding of the fourth domain of Distyostelium discoideum fi lamin ( DDFLN 4) was studied using a CABS – coarse-grained knowledge-based protein model. Our study demonstrates that CABS is capable of reproducing the unfolding free energy landscape of protein unfolding and highlights an important role of non-native interacti ons in the protein unfolding process. The obtained three peaks in the force-extension profile suggest a four-state picture of DDFLN 4 protein unfolding and correspond reasonably to the results of the all-at om simulation in explicit solvent.

Słowa kluczowe

EN

CABS; coarse-grained modeling; lattice model; mechanical unfolding of proteins

PL

CABS; modelowanie gruboziarniste; mechaniczne rozkładania białek

• Wydawca: Politechnika Gdańska
• Czasopismo: TASK Quarterly : scientific bulletin of Academic Computer Centre in Gdansk
• Rocznik: 2014
• Tom: Vol. 18, No 4
• Strony: 373--378
• Opis fizyczny: Bibliogr. 32 poz., rys.

Twórcy

autor

Kouza M.

• Faculty of Chemistry, University of Warsaw Pasteura 1, 02-093 Warsaw Poland

autor

Jamroz M.

• Faculty of Chemistry, University of Warsaw Pasteura 1, 02-093 Warsaw Poland

autor

Gront D.

• Faculty of Chemistry, University of Warsaw Pasteura 1, 02-093 Warsaw Poland

autor

Kmiecik S.

• Faculty of Chemistry, University of Warsaw Pasteura 1, 02-093 Warsaw Poland

autor

Koliński A.

• Faculty of Chemistry, University of Warsaw Pasteura 1, 02-093 Warsaw Poland

Bibliografia

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