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Abstrakty
The present study aimed to develop and validate an analytical method for determination of marbofloxacin (MAR) in veterinary chewable tablets. The isocratic reversed-phase chromatographic method was developed and validated using a Vertisep®, RP C18 column (150 mm × 4.6 mm, 5.0 μm). The mobile phase was composed of water–acetonitrile (55:45, v/v) with pH adjusted to 3.0 with ortho-phosphoric acid and a flow rate set at 0.4 mL/min. The proposed method was validated for linearity in a concentration range of 2.5 to 17.5 μg/mL with a correlation coefficient of 0.99991. The mean content of MAR found in chewable tablets was 104.40% with RSD below 2%. The accuracy expressed as average recovery of the proposed method was 98.74%, and the precision expressed as relative standard deviation among repeated analysis was 0.55%. The method has adequate sensitivity with detection and quantitation limits of 0.25 and 0.81 μg/mL, respectively. Based on the presented results and according to the ICH and AOAC guidelines on validation of analytical methods, the proposed method was considered precise, accurate with adequate sensitivity, and robust in the MAR quantitative analysis. Therefore, the method can be used in the quality control of chewable veterinary tablets containing MAR.
Słowa kluczowe
Czasopismo
Rocznik
Tom
Strony
291--293
Opis fizyczny
Bibliogr. 31 poz., rys., tab.
Twórcy
autor
- Programa de Pós-Graduação em Farmácia, Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição, Universidade Federal de Mato Grosso do Sul, Brazil
autor
- Programa de Pós-Graduação em Farmácia, Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição, Universidade Federal de Mato Grosso do Sul, Brazil
autor
- Departamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil
autor
- Instituto de Física, Universidade Federal de Mato Grosso do Sul, Brazil
autor
- Programa de Pós-Graduação em Farmácia, Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição, Universidade Federal de Mato Grosso do Sul, Brazil
Bibliografia
- [1] Mahmood, A. H.; Medley, G. A.; Grice, J. E.; Liu, X.; Roberts, M. S. Determination of trovafloxacin and marbofloxacin in sheep plasma samples by hplc using uv detection J. Pharm. Biomed. Anal. 2012, 62, 220–221.
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- [3] http://bp2012.infostar.com.cn/Bp2012.aspx?a=query&title=%22Marbofloxacin%22&tab=a-z+index&l=M&xh=19 (accessed on 15.04.2014).
- [4] http://www.chemicalize.org/structure/#!mol=marbofloxacin&source=fp (accessed on 21.05.2014).
- [5] Jiménez-Lozano, E.; Marqués, I.; Barrón, D.; Beltrán, J. L.; Baarbosa, J. Anal. Chim. Acta. 2002, 464, 37–45.
- [6] Barbosa, J.; Barrón, D.; Cano, J.; Jiménez-Lozano, E.; Sanz-Nebot, V.; Toro, I. J. Pharm. Biomed. Anal. 2001, 24, 1087–1098.
- [7] Mahamood, A. H.; Medley, G. A.; Grice, J. E.; Liu, X.; Roberts, M. S. J. Pharm. Biomed. Anal. 2012, 62, 220–223.
- [8] Garcia, M. A.; Solans, C.; Amarayona, J. J.; Rueda, S.; Bregante, M. A. J. Chromatogr. B. 1999, 729, 157–161.
- [9] Milanova, A.; Petrova, D. K.; Stanilova, S. A. J. Liq. Chromatogr. R T. 2012, 35, 1130–1139.
- [10] Cañada-Cañada, F.; Arancibia, J. A.; Escandar, G. M.; Ibañez, G. A.; Mansilla, A. E.; Muñoz de La Peña, A.; Olivieri, A. C. J. Chromatogr. A. 2009, 1216, 4868–4876.
- [11] González, C.; Moreno, L.; Small, J.; Jones, D. G.; Bruni, S. F. S. Anal. Chim. Acta. 2006, 560, 227–234.
- [12] Hernández, M.; Borrull, F.; Calull, M. Trac-Trend Anal. Chem. 2003, 22, 416–420.
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- [15] Marazuela, M. D.; Moreno-Bondi, M. C. J. Chromatogr. A. 2004, 1034, 25–32.
- [16] Di Garcia, A.; Nazzari, M. J. Chromatogr. A. 2002, 974, 53–89.
- [17] Hoff, N. V.; De Wasch, K.; Okerman, L.; Reybroeck, W.; Poelmans, S.; Noppe, H.; De Brabander, H. Anal. Chim. Acta. 2005, 529, 265–272.
- [18] Kaklamanos, G.; Vincent, U.; Von Holst, C. J. Chromatogr. A. 2013, 1293, 60–74.
- [19] Dasenaki, M. E.; Thomaidis, N. S. Anal. Chim. Acta. 2015, 880, 103–121.
- [20] Rubies, A.; Vaquerizo, R.; Centrich, F.; Compaño, R.; Granados, M.; Prat, M. D. Talanta 2007, 72, 269–276.
- [21] Cepurnieks, G.; Rjabova, J.; Zacs, D.; Baartkevics, V. J. Pharm. Biomed. Anal. 2015, 102, 184–192.
- [22] Zhan, J.; Yu, X. J.; Zhong, Y. Y.; Zhang, Z. T.; Cui, X. M.; Peng, J. F.; Feng, R.; Liu, X. T.; Zhu, Y. J. Chromatogr. B. 2012, 906, 48–57.
- [23] Chen, Y.; Schwack, W. J. Chromatogr. A. 2014, 1356, 249–257.
- [24] Shao, B.; Chen, D.; Zhang, J.; Wu, Y.; Sun, C. J. Chromatogr. A. 2009, 1216, 8312–8318.
- [25] Kemper N. Ecological Indicators 2008, 8, 1–13.
- [26] Saifrtová, M.; Nováková, L.; Lino, C.; Pena, A.; Solich, P. Anal. Chim. Acta. 2009, 649, 158–179.
- [27] Prat, M. D.; Benito, J.; Compaño, R.; Hernández-Arteseros, J. A.; Granados, M. J. Chromatogr. A. 2004, 1041, 27–33.
- [28] Indian Pharmacopoeia. The Controller of Publication, 5th ed. New Delhi, 2007.
- [29] United States Pharmacopeia. United States Pharmacopeial Convention, 32ª ed. Rockville, United States of America, 2008.
- [30] AOAC. Association of Official Analytical Chemists Official Methods of Analysis, 18 ed. 2006.
- [31] Harmonized Tripartite Guideline. Validation of analytical methods: definitions and terminology, ICH Topic Q2A. London, 1994, 6 p.
Uwagi
PL
Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2019).
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-052a3f57-7924-4f1f-8d6f-5be196c6e015