Physicochemical properties of the novel biphasic hydroxyapatite–magnesium phosphate biomaterial

• Autorzy: Pijocha D. , Zima A. , Paszkiewicz Z. , Ślósarczyk A.
• Języki publikacji: EN

Abstrakty

EN

Besides high-temperature calcium phosphates (CaPs), low-temperature calcium phosphate bone cements (CPCs), due to excellent biological properties: bioactivity, biocompability and osteoconductivity, are successfully used as bone substitutes. However, some disadvantages, related mainly to their low resorption rate and poor mechanical properties result in limited range of applications of these implant materials to non-loaded places in the skeletal system. To overcome this problem, magnesium phosphate cements (MPCs) with high strength have been considered as biomaterials. The main disadvantage of MPCs is that the acid-base setting reaction is an exothermic process that must be strictly controlled to avoid tissue necrosis. In this work, a new composite bone substitute (Hydroxyapatite Magnesium Phosphate Material – HMPM) based on hydroxyapatite (HA) and magnesium phosphate cement (MPC) with sodium pyrophosphate applied as a retardant of setting reaction was obtained. Its setting time was adequate for clinical applications. Combining properties of HA and MPC has made it possible to obtain microporous (showing bimodal pore size distribution in the range of 0.005–1.700 micrometers) potential implant material showing good surgical handiness and sufficient mechanical strength. Effectiveness of sodium pyrophosphate as a retardant of exothermic setting reaction of the new cement formulation was confirmed. After setting and hardening, the material consisted of hydroxyapatite and struvite as crystalline phases. Unreacted magnesium oxide was not detected.

Słowa kluczowe

EN

composite; bone substitute; hydroxyapatite; magnesium phosphate cement

PL

kompozyty; hydroksyapatyt; materiałoznawstwo

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Acta of Bioengineering and Biomechanics
• Rocznik: 2013
• Tom: Vol. 15, no. 3
• Strony: 53--63
• Opis fizyczny: Bibliogr. 38 poz., rys., tab., wykr.

Twórcy

autor

Pijocha D.

• AGH – University of Science and Technology, Cracow, Poland

autor

Zima A.

• AGH – University of Science and Technology, Cracow, Poland

autor

Paszkiewicz Z.

• AGH – University of Science and Technology, Cracow, Poland

autor

Ślósarczyk A.

• AGH – University of Science and Technology, Cracow, Poland

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