Fibrous systems with programmed biological-activity and their application in medical practice

• Autorzy: Skundric P. , Medovic A. , Kostic M.
• Języki publikacji: EN

Abstrakty

EN

An effective two-stage method for obtaining both biologically activated fibres with antibacterial and anaesthetic activity and biologically activated complex fibres -insulin as an artificial store of insulin has been developed. The first stage involves the formation of reactive functional groups by chemical modification, followed by the second stage where the fibres are modified with chemotherapeutic agent solutions. This paper presents the results of obtaining biologically activated fibres with antibacterial and anaesthetic activity as well as an artificial store of insulin in the form of complex ion-exchanged fibre-insulin. The level of immobilisation of the drug in the antibacterial fibre amounts to 140 mg of gentamicin sulphate per 1 g of fibres, in the anaesthetic fibre 180 mg of procaine hydrochloride per 1 g of fibres, and in the fibrous store of insulin 800 mg of insulin per 1 g of fibres.

Słowa kluczowe

EN

biologically activated fibres; antibacterial activity; anaesthetic activity; insulin; gentamicin sulphate; procaine hydrochloride

PL

biologicznie aktywne włókna; działanie przeciwbakteryjne; działanie znieczulające; insulina; siarczan gentamycyny; chlorowodorek prokainy

• Wydawca: Lodz University of Technology, Faculty of Material Technologies and Textile Design
• Czasopismo: Autex Research Journal
• Rocznik: 2002
• Tom: Vol. 2, no. 2
• Strony: 78--84
• Opis fizyczny: Bibliogr. 7 poz.

Twórcy

autor

Skundric P.

• Junior College for Textiles Starine Novaka 24, 11000 Belgrade, Yugoslavia

autor

Medovic A.

• Junior College for Textiles Starine Novaka 24, 11000 Belgrade, Yugoslavia

autor

Kostic M.

• Department of Textile Engineering, Faculty of Technology and Metallurgy, University of Belgrade Karnegijeva 4, 11000 Belgrade, Yugoslavia

Bibliografia

• 1. Jagur-Grozdinski, J: 'Biomedical application of functional polymers', Reactive & Functional Polymers, Vol 39 (1999), pp 99-138
• 2. Sharma, N D: 'Textiles for Biological and Medical Application', Man-made Textiles in India, Vol 32 No 10 (1989) pp 361-364, Vol 32 No 11 (1989), pp 390-395
• 3. Fibres with Special Properties (in Russian), Ed. Vol'f, L A, Khimiya, Moscow (1980), IB No 1118
• 4. Skundric, P D, Medovic, A H, Kostic, M M, Jovanovic, R S and Popovic, B B: 'Biologically-activated fibres, obtaining and uses' (in Serbian), Hemijska vlakna, Vol 36 No 1-4 (1996), pp 37-47
• 5. Langer, R S: 'New Drug Delivery Systems', Drug Therapy, April (1983), pp 217-229
• 6. Varagic, V M and Milosevic M P: Pharmacology (in Serbian), Elit-Medica, Belgrade (1994)
• 7. Buchenska, J: 'Pan Fibres with Antibacterial Properties', Fibres & Textiles in Eastern Europe, Vol 4 No 1 (1996), pp 53-59