Determination of diffusion coefficient and permeability through the barrier of substance in simulated biomedical systems

• Autorzy: Adach A. , Skassa A. , Bugalska A. , Kister N.

Identyfikatory

DOI

10.1515/cpe - 2017 - 00 41

• Języki publikacji: EN

Abstrakty

EN

The investigations deal with mass transfer in simulated biomedical systems. The modification of classical diffusion chamber, sequential unit (SU) system, imitated different biomedical setups, boundary conditions. The experiments simulated: diffusion chamber (also with two barriers), transport through the membrane to the blood stream, transport from the stent eluting drug simultaneously to the vessel cells and to the blood stream. The concentrations of substances and the relative mass increases/decreases for SU systems indicate that the order of the curves follows the order of mass transfer resistances. The strong dependence of mass transfer rates versus type of diffusing substance was confirmed. The calculated drug fluxes, diffusion coefficients, permeation coefficients are convergent with literature. Permeation coefficients for complex sequential systems can be estimated as parallel connexion of constituent coefficients. Experiments approved functionality of the SU for investigations in a simulated biomedical system. Obtained data were used for numerical verification.

Słowa kluczowe

EN

drug release; substance transfer; diffusion chamber; biomedical systems

PL

uwalnianie leku; transfer substancji; komora dyfuzyjna; systemy biomedyczne

• Wydawca: Komitet Inżynierii Chemicznej i Procesowej Polskiej Akademii Nauk
• Czasopismo: Chemical and Process Engineering
• Rocznik: 2017
• Tom: Vol. 38, nr 4
• Strony: 543--554
• Opis fizyczny: Bibliogr. 21 poz., rys., tab.

Twórcy

autor

Adach A.

• 1Warsaw University of Technology, Faculty of Chemical and Process Engineering, Waryńskiego 1, 00-645 Warsaw, Poland

autor

Skassa A.

• 1Warsaw University of Technology, Faculty of Chemical and Process Engineering, Waryńskiego 1, 00-645 Warsaw, Poland

autor

Bugalska A.

• 1Warsaw University of Technology, Faculty of Chemical and Process Engineering, Waryńskiego 1, 00-645 Warsaw, Poland

autor

Kister N.

Bibliografia

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Uwagi

PL

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę (zadania 2017)