Bifenylo-4-amina. Dokumentacja proponowanych wartości dopuszczalnych poziomów narażenia zawodowego

Starek, A.

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Bifenylo-4-amina. Dokumentacja proponowanych wartości dopuszczalnych poziomów narażenia zawodowego

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Starek A.

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Warianty tytułu

4-Aminobiphenyl

Języki publikacji

Abstrakty

Bifenylo-4-amina (BA) jest substancją stałą, występującą w postaci wolnej aminy lub soli amoniowych z kwasami nieorganicznymi. Pierwsza postać rozpuszcza się w rozpuszczalnikach organicznych, podczas gdy druga w wodzie. Związek może występować także jako zanieczyszczenie aniliny oraz innych amin aromatycznych i ich pochodnych.BA stosowano jako antyutleniacz w przemyśle gumowym oraz jako półprodukt do syntezy barwników azowych. BA wykazuje słabą toksyczność ostrą i przewlekłą, ma działanie mutagenne po aktywacji metabolicznej oraz indukuje nowotwory, głównie raka pęcherza moczowego, u ludzi i zwierząt. Związek został zaliczony do grupy 1., tj. do czynników rakotwórczych dla ludzi, zgodnie z kryteriami IARC.W celu ustalenia wartości NDS bifenylo-4-aminy zastosowano metodę obliczeniową, opartą na przeliczeniu potencjału rakotwórczego związku obserwowanego u myszy na taki sam potencjał u człowieka. Na podstawie dawki BA wchłoniętej przez mysz i obserwowanego efektu kancerogennego, obliczono ekwiwalentną dawkę dla człowieka, przy założeniu, że ryzyko choroby nowotworowej wynosi lO-3. Następnie wchłoniętą dawkę tego związku przeliczono na jego stężenie w powietrzu środowiska pracy.Zaproponowano przyjęcie wartości NDS na poziomie 0,001 mg/m3 jako średnie stężenie ważone 8-godzinnym dniem pracy.

4-Aminobiphenyl (BA) (CAS Registry No. 92-67-1) is a solid substance. It is used in rubber industry as an antioxidant and in synthesis of azo dye. BA is relatively low toxic but it is highly genotoxic and carcinogenic. The oral LD50 values for this compound in rodents range from 205 to 500 mg/kg b.w. BA and its metabolite IV-hydroxy-4-aminobiphenyl demonstrate the ability to induce gene mutations, usually in bacterial tests. This and other metabolites produce adducts with DNA and RNA of bladder epithelial cells. Carcinogenic potential of BA has been evidenced in some animal species and human beings. The compound induces bladder tumours. The proposed maximum exposure limit MAC (TWA) - 0.001 mg/m3 was calculate on the basis of slope factor (SF = 21 mg/kg/day) and accepted risk at 10m3.

Słowa kluczowe

bifenylo-4-amina działanie rakotwórcze wartość NDS narażenie zawodowe

4-aminobiphenyl MAC-values carcinogenicity occupational exposure

Wydawca

Centralny Instytut Ochrony Pracy - Państwowy Instytut Badawczy

Czasopismo

Podstawy i Metody Oceny Środowiska Pracy

Rocznik

2002

Tom

Nr 1 (31)

Strony

5--23

Opis fizyczny

Bibliogr. 78 poz., rys., tab.

Twórcy

autor

Starek A.

STAREK Collegium Medicum Uniwersytetu Jagiellońskiego 30-688 Kraków ul. 30-688 Kraków ul. Medyczna 9

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Bibliografia

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