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Tytuł artykułu

Multivariate statistical analysis of tropane alkaloids in Anisodus tanguticus (Maxim.) Pascher from different regions to trace geographical origins

Identyfikatory
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Anisodus tanguticus (Maxim.) Pascher is an important Tibetan folk medicine and the source of tropane alkaloids (TAs) grown in Qinghai-Tibet Plateau. There are marked differences in quality of A. tanguticus from geographic areas. The aim of present research was to establish a method for the quantitative analysis of TAs coupled with chemometrics analysis to trace geographical origins. Qualitative analysis of TAs in A. tanguticus was carried out using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry and quantitative analysis of TAs in different plant organs from different geographical origin was achieved. Contents of TAs were subjected to the principal component analysis, and orthogonal partial least-squares discriminant analysis. The contents of the three marker compounds (anisodamine, anisodine and atropine) in the roots and acrial parts of A. tanguticus were positive correlated and varied significantly from different geographical origins. Principal component analysis, and orthogonal partial least-squares discriminant analysis results showed excellent discrimination between different geographical origin of A. tanguticus. This study could provide comprehensive evaluation and further utilization of A. tanguticus resources.
Rocznik
Strony
422--429
Opis fizyczny
Bibliogr. 22 poz., tab., rys., wykr.
Twórcy
autor
  • CAS Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Xining, China
  • University of Chinese Academy of Sciences, Beijing, China
autor
  • Qinghai Normal University, Xining, China
autor
  • CAS Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Xining, China
  • University of Chinese Academy of Sciences, Beijing, China
autor
  • CAS Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Xining, China
  • University of Chinese Academy of Sciences, Beijing, China
  • CAS Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Xining, China
  • University of Chinese Academy of Sciences, Beijing, China
autor
  • CAS Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Xining, China
Bibliografia
  • 1. Adamse, P.; Egmond, H. V.; Noordam, M. Y.; Mulder, P. P. J.; Nijs, M. TAs in food: poisoning incidents. Qual. Assur. Saf. Crop. 2014, 6, 15–24.
  • 2. Kai, G.Y.; Sheng, Y.; Zhang, Y.; et al. Effects of different elicitors on yield of tropane alkaloids in hairy root of Anisodus Acutangulus. Mol. Biol. Rep. 2012, 39, 1721–9.
  • 3. Nguyena, T. K. O.; Jamali, A.; Lanoue, A.; Gontier, E.; Dauwe, R. Unravelling the architecture and dynamics of tropane alkaloid biosynthesis pathways using metabolite correlation networks. Phytochem 2015, 116, 94–103.
  • 4. Ana, R. T.; Roberto, R. G.; Jos e, L. M. V.; Antonia, G. F. Analytical methods, occurrence and trends of tropane alkaloids and calystegines: an update. J. Chromatogr. A. 2018, 1564, 1–15.
  • 5. Zhang, P. T.; Li, Y. M.; Liu, G. H.; et al. Simultaneous determination of atropine, scopolamine and anisodamine from Hyoscyamus niger L. in rat plasma by high-performance liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetics study. J. Sep. Sci. 2014, 37, 2664–74.
  • 6. Wang, H.; Zhang, X. F.; Chen, G. C.; Li, T. C.; Zhou, G. Y.; Shen, J. W. Comparative study of contents of four TAs in cultural and wild Anisodus tanguticus. Acta Bot. Boreal. 2005, 25(3), 575–7.
  • 7. Zhang, X.F.; Wang, H. The variation of the contents of four TAs in Anisodus tanguticus. Acta Bot. Boreal. 2002, 22(3), 630–4.
  • 8. Boros, B.; Farkas, A.; Jakabova, S.; Bacskay, I.; Kilar, F.; Felinger, A. LC-MS quantitative determination of atropine and scopolamine in the floral nectar of Datura Species. Chromatogr 2010, 71, 43–9.
  • 9. Drager, B. Biotechnology of Solanaceae alkaloids: a model or an industrial perspective. In Medicinal Plant Biotechnology; pp. 237–65; Kayser, O, Quax, WJ, Eds. WILEY-VCH Verlag: Weinheim, 2007.
  • 10. Oniszczuk, A.; Waksmundzka-Hajnos, M.; Gadzikowska, M.; Podgórski, R.; Oniszczuk, T. Influence of sample preparation methods on the quantitation of selected TAs from herb of Datura innoxia Mill. by HPTLC. Acta Chromatogr. 2013, 25, 545–54.
  • 11. Xu, J.Y.; Zhu, P. C.; Zhou, G. Y.; Chen, G. C. Determination of TAs in Anisodus tanguticus (Maxim.) Pascher by HPLC. Chin J. Analy Labor. 2009, 28, 300–1.
  • 12. Wang, H.; Shen, J.W.; Zhang, X. The relationship of four TAs in Anisodus tanguticus and altitude. China J. Chin. Materia. Medi. 2002, 27, 151–2.
  • 13. Chen, H. X.; Chen, Y.; Du, P.; Han, F. M. LC-MS for identification and elucidation of the structure of in-vivo and in-vitro metabolites of atropine. Chromatogr 2007, 65, 413–8.
  • 14. Gapparov, A. M.; Aripova, S.F.; Tashkhodzhaev, B.; Levkovich, M. G.; Aripov, O. Convolinine, a new alkaloid from Convolvulus subhirsutus of Uzbekistan flora. Chem. Nat. Compd. 2010, 46, 590–2.
  • 15. Chen, H. X.; Wang, H.; Chen, Y.; Zhang, H. Liquid chromatography-tandem mass spectrometry analysis of anisodamine and its phase I and II metabolites in rat urine. J. Chroma. B. 2005, 824, 21–9.
  • 16. Chen, H. X.; Chen, Y.; Du, P.; Han, F. M. Structural elucidation of in vivo and in vitro metabolites of anisodine by liquid chromatography-tandem mass spectrometry. J. Pharmaceut. Biomed. 2007, 44, 773–8.
  • 17. Fischer, C.; Kwon, M.; Ro, D. K. Isolation, expression and biochemical characterization of recombinant hyoscyamine-6β-hydroxylase from Brugmansia sanguinea-tuning the scopolamine production. Med. Chem. Comm. 2018, 9(5), 888–92.
  • 18. Jesús, M. S.; Roberto, R. G.; Antonia, G. F. Multi-analysis determination of tropane alkaloids in cereals and solanaceaes seeds by liquid chromatography coupled to single stage Exactive-Orbitrap. J. Chroma. A. 2017, 1518, 46–58.
  • 19. Berkov, S.; Evstatieva, L.; Popov, S. Alkaloids in Bulgarian Pancratium maritimum L. Z. Naturforsch. C. J. Biosci. 2004, 59, 65–9.
  • 20. Hashimoto, T.; Hayashi, A.; Amano, Y.; et al. Hyoscyamine 6 beta-hydroxylase, an enzyme involved in tropane alkaloid biosynthesis, is localized at the pericycle of the root. J. Biol. Chem. 1991, 266, 4648–53.
  • 21. Qi, Y.; Pi, Z.; Liu, S.; Song, F.; Lin, N.; Liu, Z. A metabonomic study of adjuvantinduced arthritis in rats using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Mol. BioSys. 2014, 10(10), 2617–25.
  • 22. Wu, X.; Li, Y.; Wang, Q.; Li, W.; Feng, Y. Effects of berberine and pomegranate seed oil on plasma phospholipid metabolites associated with risks of type 2 diabetes mellitus by U-HPLC Q-TOF-MS. J. Chomatogr. B. 2015, 1007, 110–20.
Uwagi
Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-01c9f790-3987-4f61-bab7-ae85a06358f6
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