Dynamic bubble tensiometry as a useful tool for assessment of physicochemical interactions of liposomal drug carriers with respiratory tract

• Autorzy: Kramek-Romanowska K. , Sosnowski T. R.
• Języki publikacji: EN

Abstrakty

EN

This article presents an experimental investigation of physicochemical interactions of novel liposomal drug carriers intended for inhalation with model lung surfactant system. The research was done with the use of maximum bubble pressure (MBP) method to measure changes of dynamic surface tension of pulmonary surfactant system after contact with liposomal colloids made of lecithin and lecithin/cholesterol (3:1 w/w) before and after 5 and 10 minutes of nebulisation by pneumatic nebulizer. What is important to point, MBP method allows the discussion of measured phenomena with reference to the time scales characteristic for the changes of alveolar surface area during the breathing cycle. Obtained results may have a potential application during design and development of new therapeutic liposomal formulations for treatment of respiratory as well as systemic diseases.

Słowa kluczowe

EN

pulmonary surfactant; liposomes; inhalation; surface tension; adsorption

PL

surfaktant płucny; liposomy; inhalacja; napięcie powierzchniowe; adsorpcja

• Wydawca: Foundation for Young Scientists
• Czasopismo: Challenges of Modern Technology
• Rocznik: 2015
• Tom: Vol. 6, no. 4
• Strony: 23--26
• Opis fizyczny: Bibliogr. 14 poz., wykr., tab.

Twórcy

autor

Kramek-Romanowska K.

• Warsaw University of Technology, Faculty of Chemical and Process Engineering Waryńskiego 1, 00-645 Warsaw, Poland

autor

Sosnowski T. R.

• Warsaw University of Technology, Faculty of Chemical and Process Engineering Waryńskiego 1, 00-645 Warsaw, Poland

Bibliografia

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