Investigation of interactions between dermorphin analogs and µ-opioid receptor

• Autorzy: Karczyńska A. , Zaborowski B. , Ślusarz M.
• Języki publikacji: EN

Abstrakty

EN

Opioid receptors play the pain control function in the body. Most of the research is carried out to find the most effective analgesic. The earliest analgesic i s morphine, however, unfortunately it has many side effects [Mizoguchi H et al. 2003 J. Pharmacol Sci. 93 423]. At a later time dermorphin was discovered as another potent analgesic [Mont ecucchi P C et al. 1981 Int. J. Pept. Protein Res. 17 275]. Unfortunately, this peptide is not resistant to enzymatic metabolism [Kisara K et al. 1986 Br. J. Pharmacol. 87 183; Sasaki Y et al. 1985 Neuropeptides 5 391]. The objective of this study is to search for new opioid analgesics by in vestigation of interactions between dermorphin analogs and the μ -opioid receptor using molecular modeling methods. MOPR ( μ -Opioid Peptide Receptor) complexes with several ligands (with kno wn biological activity) were modeled to explain how the structure of the complex was related to the biological activity. The investigated dermorphin analogs containing [ DMT 1 , D -Arg 2 ] (especially tetrapeptides) may become a good alternative for the currently used an algesics.

Słowa kluczowe

EN

molecular modeling; opioid receptors; defmorphin; molecular docking; drug design

PL

modelowanie molekularne; receptory opioidowe; dokująca molekularna; projektowanie leków; dermorfina

• Wydawca: Politechnika Gdańska
• Czasopismo: TASK Quarterly : scientific bulletin of Academic Computer Centre in Gdansk
• Rocznik: 2014
• Tom: Vol. 18, No 4
• Strony: 331--336
• Opis fizyczny: Bibliogr. 13 poz., rys., tab.

Twórcy

autor

Karczyńska A.

• Department of Chemistry, University of Gdansk Wita Stwosza 63, 80-952 Gdansk, Poland

autor

Zaborowski B.

• Department of Chemistry, University of Gdansk Wita Stwosza 63, 80-952 Gdansk, Poland

autor

Ślusarz M.

• Department of Chemistry, University of Gdansk Wita Stwosza 63, 80-952 Gdansk, Poland

Bibliografia

• [1] Mizoguchi H, Wu H E, Narita M, Sora I, Hall S F, Uhl G R et al. 2003 J. Pharmacol Sci. 93 423
• [2] Montecucchi P C, Castiglione R de, Piani S and Erspamer V G 1981 Int. J. Pept. Protein Res. 17 275
• [3] Kisara K, Sakurada S, Sakurada T, Sasaki Y, Sato T, Suzuki K et al. 1986 Br. J. Pharmacol. 87 183
• [4] Sasaki Y, Matsui M, Fujita H, Hosono M, Taguchi M, Suzuki K et al. 1985 Neuropeptides 5 391
• [5] Satoh M and Minami M 1995 Pharmacology & therapeutics 68 343
• [6] Portoghese P S, Sultana M and Takemori A E 1990 J. Med. Chem. 33 (6)1714
• [7] Portoghese P S, Sultana M and Takemori A E 1990 J. Med. Chem. 33 ( 6 ) 1714
• [8] Takemori A E, Sultana M, Nagase H and Portoghese P S 1992 Life Sci. 50 ( 20 ) 1491
• [9] Sagan S, Amiche M, Delfour A, Camus A, Mor A and Nicolas P 1989 Biochem. Biophys. Res. Commun 163 726
• [10] Mizoguchi H, Bagetta G and Sakurada S 2011 Peptides 32 421
• [11] Schiller P W, Dung N T M, Chung N N and Lemieux C 1989 Journal of medicinal chemistry 32 698
• [12] Meyer M and McLaurin B 1995 Pharmacology Biochemistry 51 149
• [13] Schiller P W, Nguyen T M D, Berezowska I, Dupuis S, Weltrowska G, Chung N N, Lemieux C 2000 European journal of medicinal chemistry 35 895