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Numerical and experimental analysis of balloon angioplasty impact on flow hemodynamics improvement

Treść / Zawartość
Identyfikatory
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Purpose: The paper focuses on the numerical and experimental evaluation of the fluid flow inside chosen fragments of blood vessels. In the first stage of the study, the experimental tests were conducted using a research test stand, designed to be used in this evaluation. The study evaluated the blood flow through a silicone vessel with an implanted coronary stent. Methods: The PIV method was used in order to visualize the flow vectors inside a silicone vessel. Deformed vessel geometry implemented for computational fluid dynamics purposes was obtained owing to a non-linear simulation of the stent expansion (angioplasty process) in a silicone vessel. Additionally, a vessel model with a statistical 55% area stenosis and an irregular real vessel with an atherosclerotic plaque were also subjected to analysis from the hemodynamic flow point of view. A vessel with a statistical stenosis was also used to simulate the angioplasty process, which resulted in obtaining a flow domain for the vessel with an atherosclerotic plaque after the stent implantation. Results: For each case, distributions of parameters such as OSI or TAWSS were also analyzed and discussed. The areas of low TAWSS values appear close to the stent struts. Conclusions: Stents with increased diameters, compared to the normal vessel diameter, create a higher risk of occurrence of the areas with low WSS values. Excessive stent deformation can cause inflammation by injuring the vessel and can initiate the restenosis and thrombotic phenomena through the increased vessel diameter.
Rocznik
Strony
169--183
Opis fizyczny
Bibliogr. 24 poz., rys., tab., wykr.
Twórcy
  • Military University of Technology, Faculty of Mechanical Engineering, Warsaw, Poland
  • Military University of Technology, Faculty of Mechanical Engineering, Warsaw, Poland
  • Institute of Mechanics and Computational Engineering, Military University of Technology, Faculty of Mechanical Engineering, ul. Gen. Sylwestra Kaliskiego 2, 00-908 Warsaw
  • Silesian University of Technology, Faculty of Biomedical Engineering, Gliwice, Poland
  • Andrzej Frycz-Modrzewski Krakow University, Department of Cardiology, Center for Cardiovascular Research and Development American Heart of Poland, Kraków, Poland.
Bibliografia
  • [1] BEIER S., ORMISTON J., WEBSTER M., CATER J., NORRIS S., MEDRANO-GRACIA P., YOUNG A., COWAN B., Hemodynamics in Idealized Stented Coronary Arteries: Important Stent Design Considerations, Ann. Biomed. Eng., 2016, 44, 315–329, DOI: 10.1007/s10439-015-1387-3.
  • [2] BUKAŁA J., KWIATKOWSKI P., MAŁACHOWSKI J., Numerical analysis of crimping and inflation process of balloon-expandable coronary stent using implicit solution, Int. J. Numer. Method. Biomed. Eng., 2017, 33(12), DOI: 10.1002/cnm.2890.
  • [3] BUKAŁA J., KWIATKOWSKI P., MAŁACHOWSKI J., Numerical analysis of stent expansion process in coronary artery stenosis with the use of non-compliant balloon, Biocybern. Biomed. Eng., 2016, 36, 145–156, DOI: 10.1016/j.bbe.2015.10.009.
  • [4] CHEN Y., XIONG Y., JIANG W., YAN F., GUO M., WANG Q., FAN Y., Numerical simulation on the effects of drug eluting stents at different Reynolds numbers on hemodynamic and drug concentration distribution, Biomed. Eng. Online, 2015, 14, DOI: 10.1186/1475-925X-14-S1-S16.
  • [5] CHIASTRA C., MORLACCHI S., GALLO D., MORBIDUCCI U., CARDENES R., LARRABIDE I., MIGLIAVACCA F., Computational fluid dynamic simulations of image-based stented coronary bifurcation models, J. R. Soc. Interface, 2013, 10, DOI: 10.1098/rsif.2013.0193.
  • [6] CHO Y.I., KENSEY K.R., Effects of the non-Newtonian viscosity of blood on flows in a diseased arterial vessel. Part 1: Steady flows, Biorheology, 1991, 28, 241–262, DOI: 10.3233/BIR-1991-283-415.
  • [7] JÓŹWIK K., OBIDOWSKI D., Numerical simulations of the blood flow through vertebral arteries, J. Biomech., 2010, 43, 177–185, DOI: 10.1016/j.jbiomech.2009.09.026.
  • [8] KOPERNIK M., TOKARCZYK P., Development of multi-phase models of blood flow for medium-sized vessels with stenosis, Acta Bioeng. Biomech., 2019, 21 (2), 63–70.
  • [9] KOSKINAS K.C., CHATZIZISIS Y.S., ANTONIADIS A.P., GIANNOGLOU G.D., Role of Endothelial Shear Stress in Stent Restenosis and Thrombosis: Pathophysiologic Mechanisms and Implications for Clinical Translation, J. Am. Coll. Cardiol, 2012, 59, 1337–1349, DOI: 10.1016/J.JACC.2011.10.903.
  • [10] KOZUŃ M., PŁONEK T., JASIŃSKI M., FILIPIAK J., Effect of dissection on the mechanical properties of human ascending aorta and human ascending aorta aneurysm, Acta Bioeng. Biomech., 2019, 21 (2), 127–134.
  • [11] KWIATKOWSKI P.S., MAŁACHOWSKI J., JAKUBAS-KWIATKOWSKA W., GOŁĘBIEWSKI S., GIL R.J., KWASIBORSKI P., KAŁUŻA B., SUTKOWSKA E., The effects of types of guidewires and pressure applied during stent implantation in the main vessel on the incidence of damage to coronary guidewires during angioplasty of coronary bifurcation lesions – Wide Beast study, J. Interv. Cardiol., 2018, 31, 599–607, DOI: 10.1111/joic.12523.
  • [12] LADISA J.F., OLSON L.E., MOLTHEN R.C., HETTRICK D.A., PRATT P.F., HARDEL M.D., KERSTEN J.R., WARLTIER D.C., PAGEL P.S., Alterations in wall shear stress predict sites of neointimal hyperplasia after stent implantation in rabbit iliac arteries, Am. J. Physiol. Circ. Physiol., 2005, DOI: 10.1152/ajpheart.01107.2004.
  • [13] LANTZ J., RENNER J., KARLSSON M., Wall shear stress in a subject specific human aorta -Influence of fluid-structure interaction, Int. J. Appl. Mech., 2011, 4, 759–778, DOI: 10.1142/S1758825111001226.
  • [14] LESIEUR M., Fluid Mechanics and its Applications: Turbulence in fluids, 4th ed., Springer, 2008. [15] MAŁEK A.M., ALPER S.L., IZUMO S., Hemodynamic shear stress and its role in atherosclerosis, JAMA, 1999, 282, 2035– 2042, DOI: 10.1001/jama.282.21.2035.
  • [16] PASZENDA Z., MARCINIAK J., BĘDZIŃSKI R., RUSIŃSKI E., SMOLNICKI T., Biomechanical characteristics of stent-coronary vessel system, Acta Bioeng. Biomech., 2002, 4 (1).
  • [17] RABEN J.S., MORLACCHI S., BURZOTTA F., MIGLIAVACCA F., VLACHOS P.P., Local blood flow patterns in stented coronary bifurcations: An experimental and numerical study, J. Appl. Biomater. Funct. Mater., 2015, 13, DOI: 10.5301/jabfm.5000217.
  • [18] RIGATELLI G., ZUIN M., FONG A., TAI T.T., NGUYEN T., Left main stenting induced flow disturbances on ascending aorta and aortic arch, J. Transl. Intern. Med., 7, 22–28, DOI: 10.2478/jtim-2019-0005.
  • [19] SZABADITS P., PUSKAS Z., DOBRANSZKY J., Flexibility and trackability of laser cut coronary stent systems, Acta Bioeng. Biomech., 2009, 11 (3).
  • [20] TOMASZEWSKI M., SYBILSKI K., BARANOWSKI P., MAŁACHOWSKI J., Experimental and Numerical Flow Analysis Through Arteries With Stent Using Particle Image Velocimetry And Computational Fluid Dynamics Method, Biocybern. Biomed. Eng., 2020, DOI: 10.1016/j.bbe.2020.02.010.
  • [21] TOMASZEWSKI M., BARANOWSKI P., MAŁACHOWSKI J., DAMAZIAK K., BUKAŁA J., Analysis of artery blood flow before and after angioplasty, AIP Conference Proceedings, 2018, DOI: 10.1063/1.5019068.
  • [22] WASILEWSKI J., KILJAŃSKI T., MISZALSKI-JAMKA, Role of shear stress and endothelial mechanotransduction in atherogenesis, Kardiol. Pol., 2011, 69, 717–720.
  • [23] WEI L., LEO H.L., CHEN Q., LI Z., Structural and Hemodynamic Analyses of Different Stent Structures in Curved and Stenotic Coronary Artery, Front. Bioeng. Biotechnol., 2019, 7, 1–13, DOI: 10.3389/fbioe.2019.00366.
  • [24] WILLIAMS A.R., KOO B.-K., GUNDERT T.J., FITZGERALD P.J., LADISA J.F., Local hemodynamic changes caused by main branch stent implantation and subsequent virtual side branch balloon angioplasty in a representative coronary bifurcation, J. Appl. Physiol., 2010, 109, 532–540, DOI: 10.1152/japplphysiol.00086.2010.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-008f44d1-2377-44a0-ad20-34263ebb3092
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