Development and production of radioactive sources used for cancer treatment in Brazil

• Autorzy: Rostelato M. E. C. M. , Rela P. R. , Zeituni C. A. , Feher A. , Manzoli J. E. , Moura J. A. , Moura E. S. , Silva C. P. G.
• Konferencja: International Conference on Recent Developments and Applications of Nuclear Technologies (15-17.09 2008 ; Białowieża, Poland)
• Języki publikacji: EN

Abstrakty

EN

The number of cancer patients in Brazil is increasing and part of the patients are submitted to brachytherapy treatment using iridium-192 wire and iodine-125 radioactive seeds. The Nuclear Energy Research Institute established a programme to produce iridium-192 wire and iodine-125 radioactive seeds. With the purpose of settling a laboratory for iridium-192 sources production, a wire activation method was developed and a hot cell for the wire manipulation, quality assurance and packaging was built. The iodine-125 seeds consist of a welded titanium capsule containing iodine-125 adsorbed onto a silver rod. Concerning the setup of the local production, the following activities were carried out: superficial treatment of the silver rod, development of a process to absorb the iodine in the silver rod, welding methodology to seal the seeds, leakage and contamination test and source activity measurement.

Słowa kluczowe

EN

radioactive sources production; iodine-125 seeds; iridium-192 wires; brachytherapy; cancer treatment

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2008
• Tom: Vol. 53, suppl. 2
• Strony: 99--103
• Opis fizyczny: Bibliogr. 15 poz., rys.

Twórcy

autor

Rostelato M. E. C. M.

• Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN), Centro de Tecnologia das Radiações - CTR, 2242 Lineu Prestes Ave., CEP:05508-000, Sao Paulo, SP, Brazil, Tel.: [phone], Fax: [phone]

autor

Rela P. R.

• Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN), Centro de Tecnologia das Radiações - CTR, 2242 Lineu Prestes Ave., CEP:05508-000, Sao Paulo, SP, Brazil, Tel.: [phone], Fax: [phone]

autor

Zeituni C. A.

• Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN), Centro de Tecnologia das Radiações - CTR, 2242 Lineu Prestes Ave., CEP:05508-000, Sao Paulo, SP, Brazil, Tel.: [phone], Fax: [phone]

autor

Feher A.

• Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN), Centro de Tecnologia das Radiações - CTR, 2242 Lineu Prestes Ave., CEP:05508-000, Sao Paulo, SP, Brazil, Tel.: [phone], Fax: [phone]

autor

Manzoli J. E.

• Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN), Centro de Tecnologia das Radiações - CTR, 2242 Lineu Prestes Ave., CEP:05508-000, Sao Paulo, SP, Brazil, Tel.: [phone], Fax: [phone]

autor

Moura J. A.

• Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN), Centro de Tecnologia das Radiações - CTR, 2242 Lineu Prestes Ave., CEP:05508-000, Sao Paulo, SP, Brazil, Tel.: [phone], Fax: [phone]

autor

Moura E. S.

• Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN), Centro de Tecnologia das Radiações - CTR, 2242 Lineu Prestes Ave., CEP:05508-000, Sao Paulo, SP, Brazil, Tel.: [phone], Fax: [phone]

autor

Silva C. P. G.

• Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN), Centro de Tecnologia das Radiações - CTR, 2242 Lineu Prestes Ave., CEP:05508-000, Sao Paulo, SP, Brazil, Tel.: [phone], Fax: [phone]

Bibliografia

• 1. American Urological Association Prostate Cancer (1998) Clinical guidelines panel. The management of localized prostate cancer – a patient’s guide
• 2. Blasko J, Datolli MJ, Wallner K (1997) Prostate brachytherapy. Smart Medicine Press, Washington, USA
• 3. Cieszykowska I, Piasecki A, Mielcarski M (2005) An approach to the preparation of iodine-125 seed-type source. Nukleonika 50;1:17–22
• 4.Goggen TJ (1988) Physical aspects of brachytherapy. Medical Physics Handbooks. Vol. 19. England
• 5.Grimm P (1997) Ultrasound-guided prostate permanent seed implant therapy. Swedish Medical Center’s Seattle Prostate Institute, USA
• 6. International Standard Organization (1992) Radiation protection – Sealed radioactive sources – Leakage test methods. ISO-9978
• 7. International Standard Organization (1995) Radiation protection – Sealed radioactive sources – General requirements and classification. ISO-2919
• 8. Khan FM (1997) The physics of radiation therapy. Williams & Wilkins, Baltimore, pp 418–430
• 9. Manolkar RB, Sane SU, Pillai KT, Majali MA (2003) Comparison of methods for preparation of I-125 brachytherapy source cores for the treatment of eye cancer. Appl Radiat Isot 59:145–150
• 10. Mathew C, Majali MA, Balakrishnan SA (2002) A novel approach for the adsorption of iodine-125 on silver wire as matrix for brachytherapy source for the treatment of eye and prostate cancer. Appl Radiat Isot 57:359–367
• 11. Mielcarski M, Puchalska I (2002) Deposition of Ru-106 and I-125 on silver by internal electrolysis. Nukleonika 47;2:83–86
• 12. Ministério da Sade Inca/Conprev (2008) Estimativa da incidência e mortalidade por câncer no Brasil. Rio de Janeiro
• 13. Rostelato MECM (1997) Preparacao de Fontes de Iridio-192 para Uso em Braquiterapia. IPEN/USP, Sao Paulo
• 14. Rostelato MECM (2005) Estudo e desenvolvimento de uma nova metodologia para confecção de sementes de iodo-125 para aplicação em braquiterapia. IPEN/USP, Sao Paulo
• 15. Saxena SK, Shanta A, Rajurkar NS, Majali MA (2006) Studies on the production and quality assurance of miniature I-125 radioactive sources suitable for treatment of ocular and prostate cancers. Appl Radiat Isot 64:441–447