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1 Engineering of Biomaterials

1 2007

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Injectable cell immobilization systems for bone regeneration

Granja P. L., Evangelista M. B., Bidarra S. J., Guerreiro S., Barrias C. C., Mooney D. J., Barbosa M. A.

Engineering of Biomaterials

2007

Vol. 10, no. 69-72

5-6

Cell immobilization on encapsulation has been extensively investigated with the purpose of to providing immunoisolation but few attempts have been made to use this strategy for tissue regeneration. Our research efforts are currently focused on the functionalization of natural polymers, namely poly-saccharides, to promote their interaction with biological systems. Osteoprogenitor and stem cells were immobilized within alginate microspheres conjugated with oligopeptides including the Arg-Gly-Asp (RGD) sequence. Polymers were further modified to improve their biodegradability. After immobilization and under dynamic cell culture conditions, immobilized cells were viable, proliferated and differentiated. Immobilized cell further synthesized and extracellular matrix and expressed bone phenotypic markers, which indicates the capability of this approach to promote the regeneration of bone tissue. Current efforts are focused on promoting vascularization of bone tissue by using angiogenic factors as well as endothelial cells.