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2007 | 54 | 1 |

Tytuł artykułu

Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
This review summarizes some of the recent findings concerning the long-held tenet that the enzyme, N-acetyltransferase, which is involved in the production of N-acetylserotonin, the immediate precursor of melatonin, may in fact not always control the quantity of melatonin generated. New evidence from several different laboratories indicates that hydroxyindole-O-methyltransferase, which O-methylates N-acetylserotonin to melatonin may be rate-limiting in some cases. Also, the review makes the point that melatonin's actions are uncommonly widespread in organs due to the fact that it works via membrane receptors, nuclear receptors/binding sites and receptor-independent mechanisms, i.e., the direct scavenging of free radicals. Finally, the review briefly summarizes the actions of melatonin and its metabolites in the detoxification of oxygen and nitrogen-based free radicals and related non-radical products. Via these multiple processes, melatonin is capable of influencing the metabolism of every cell in the organism.

Wydawca

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Rocznik

Tom

54

Numer

1

Opis fizyczny

p.1-9,fig.,ref.

Twórcy

autor
  • University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio , TX 78229-3900, USA
autor
autor
autor
autor

Bibliografia

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