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1
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PL
Cel i założenia: celem badań było porównanie równowagi pomiędzy składową sympatyczną i parasympatyczną u osób po uszkodzeniu rdzenia kręgowego. Materiał badawczy: przebadano 10 nietrenujących mężczyzn po urazie rdzenia kręgowego w wieku 17-34 lat. Metoda badawcza: pomiary zmienności rytmu zatokowego serca (HRV) oraz częstości skurczów serca (HR) zostały wykonane za pomocą sport-testera S 810i firmy Polar. Zarejestrowane pliki HR posłużyły do analizy zmienności rytmu zatokowego serca w programie HRV Analysis. Wnioski: przewaga mocy w zakresie niskich częstotliwości może świadczyć o dominacji części sympatycznej autonomicznego układu nerwowego. Niższa wartość mocy całkowitej u osób niepełnosprawnych może wskazywać dezorganizację w funkcjonowaniu autonomicznego układu nerwowego.
EN
Purpose of the study: the aim of the study was to compare sympathetic and parasympathetic balance in patients after spinal cord injury. Subjects: ten sedentary men after spinal cord injury at the age of 17-34 were examined. Method: the variability of the sinus rhythm (HRV) as well as the heart rate were measured by means of the Polar sport-tester S 810i. The collected data was used to analyse the sinus rhythm's variability in HRV Analysis program. Conclusions: the prevalence of low frequencies may signify/indicate dominance of sympathetic element of the autonomic nervous system. Lower values of the total force may show dysfunctioning of the autonomic nervous system after spinal cord injury.
EN
Objectives: The aim of the study was to verify whether simultaneous responses from the muscular and circulatory system occur in the driver's body under simulated conditions of a crash threat. Materials and Methods: The study was carried out in a passenger car driving simulator. The crash was included in the driving test scenario developed in an urban setting. In the group of 22 young male subjects, two physiological signals - ECG and EMG were continuously recorded. The length of the RR interval in the ECG signal was assessed. A HRV analysis was performed in the time and frequency domains for 1-minute record segments at rest (seated position), during undisturbed driving as well as during and several minutes after the crash. For the left and right side muscles: m. trapezius (TR) and m. flexor digitorum superficialis (FDS), the EMG signal amplitude was determined. The percentage of maximal voluntary contraction (MVC) was compared during driving and during the crash. Results: As for the ECG signal, it was found that in most of the drivers changes occurred in the parameter values reflecting HRV in the time domain. Significant changes were noted in the mean length of RR intervals (mRR). As for the EMG signal, the changes in the amplitude concerned the signal recorded from the FDS muscle. The changes in ECG and EMG were simultaneous in half of the cases. Conclusion: Such parameters as mRR (ECG signal) and FDS-L amplitude (EMG signal) were the responses to accident risk. Under simulated conditions, responses from the circulatory and musculoskeletal systems are not always simultaneous. The results indicate that a more complete driver's response to a crash in road traffic is obtained based on parallel recording of two physiological signals (ECG and EMG).
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This study proposes a convenient method of evaluating mental stress. The potential of monitoring changes in pupil diameter as a measure of human reliability while operating human–machine systems was examined experimentally. An experiment was carried out to clarify the relation between changes in pupil diameter and autonomic nervous activity by measuring an electrocardiogram and pupil diameter when 10 subjects completed a time-sensitive task. The electrocardiogram was measured using a multitelemeter system and pupil diameter was measured using an eye-mark recorder. Several relationships between changes in pupil diameter and autonomic nervous activity were revealed and indicated that measurement of pupil diameter was an effective indicator of autonomic nervous activity. Therefore, it may be possible to develop a monitoring system that measures changes in pupil diameter as an indicator of the mental state of workers operating human–machine systems.
EN
In this study perceived mental stress during occupational work was compared to heart rate variability (HRV) using a traditional questionnaire and a novel wristop heart rate monitor with related software. The aim was to find HRV parameters useful for mental stress detection. We found the highest correlation between perceived mental stress with the differences between the values of triangular interpolation of rythm-to-rythm (RR) interval histogram (TINN) and the root mean square of differences of successive RR intervals (RMSSD) obtained in the morning and during the workday (r = –.73 and r = –.60, respectively). The analysis shows that as the RMSSD and TINN value differences increase from night to morning, the stress decreases.
EN
Objectives: The aim of the study was to assess the mechanism of cardiovascular impairments in workers exposed to UHF-VHF radio frequency electromagnetic fi elds (EMF). Materials and Methods: Heart rate variability (HRV) was analysed using 512 normal heart beats registered at rest. The analysis concerned time-domain (STD R-R) and frequencydomain (VLF, LF, HF) parameters of HRV. Fifty nine workers (group I) with low-level and 12 workers (group II) with highlevel exposure were examined. The mean age of the subjects was 47±9 years and 41±14 years, and mean exposure duration 19.1±8.8 years and 13±4 years, in groups I and II, respectively. The groups were divided according to: $\text{E}_\text{max}$, $\text{E}_\text{dose}$, $\text{E}_\text{mean}$ for frequencies UHF, VHF and UHF+VHF: The control group consisted of 42 non-exposed subjects, aged 49±8 years. Statistical analysis comprised one-way analysis of variance, covariance analysis and logistic regression models. Results: In the exposed groups, the heart rate was higher than in the control one. Standard deviation of R-R intervals (STD R-R) was found to be signifi cantly (p = 0.0285) lower in group I (42.5±24.7 ms) compared to the control group (62.9±53.5 ms). The risk of lowered STD R-R was signifi cantly increased (OR = 2.37, p = 0.023) in group II. Both exposed groups presented signifi cantly higher VLF and LF values than the control group (p = 0.005 and p = 0.0025, respectively). The EMF-exposed groups were characterised by the dominance of the sympathetic system (LF/HF 1.3±0.35). Conclusions: The results indicate that exposure to radiofrequency EMF may affect the neurovegetative regulation.
EN
Introduction Syncope is defined as transient loss of consciousness, due to decrease in brain perfusion. The most frequent mechanism is vasovagal syncope. In many patients, the cause of syncope remains unspecified, despite an extensive diagnostic work-up. Tilt-test (TT) is an acknowledged diagnostic tool for syncope. Currently, the so-called Italian protocol of TT is most widely used. Vasovagal syncope is caused by impaired circulatory regulation in response to orthostatic stress. One of the available tools to examine the influence of the nervous system on the circulation is the analysis of heart rate variability (HRV). Despite numerous publications concerning HRV parameters and autonomic regulation in patients with syncope, direct comparisons and metaanalysis of the results is impossible, due to variability of TT protocols and study group specifications. Aim of the study As there is no uniform model of HRV during TT, we aimed to analyze HRV parameters during TT (performed according to the Italian protocol) in patients with vasovagal syncope, in order to determine the possible application of HRV measurements in clinical practice in that group of patients. Detailed objectives were: (1) analysis and comparison of HRV in patients with and without the history of syncope; (2) analysis of HRV changes in consecutive stages of TT; (3) identification of possible HRV differences between patients with positive and negative TT results. Materials and methods Patients between 18 and 50 years of age were qualified for the study, if they had a history of at least 2 incidents of syncope or presyncope within the preceeding 6 months, and if signs and symptoms indicated the vasovagal mechanism. The study group included 150 patients: 100 consecutive patients with a postive TT result (POS), and 50 consecutive patients with a negative TT result (NEG). The control group (CG) comprised 50 volunteers with no history of syncope nor presyncope, matched according to age and sex to the study group. In all patients a TT was performed according to the Italian protocol, with paced breathing at a rate of 15/min. Time-domain (meanRR, SDNN, RMSSD, pNN50) and frequency-domain (abs_LF, abs_HF, rel_LF, rel_HF, norm_LF, norm_HF, LF/HF) HRV parameters were analyzed and compared at different stages of TT in the study groups as specified above. Results 100 patients at the age of 18-44 years were included in the POS group, 50 patients at the age of 18-39 years in the NEG group, and 50 volunteers at the age of 20-39 in the CG. Volunteers in the control group developed unexpectedly high percentage of positive TT (14 patients). For consistency of analysis, the CG was thus subdivided according to the result of the TT into CG_POS (positive result of TT) – 14 patients, and CG_NEG (negative result of TT) – 36 patients. Based on HRV analaysis, no significant differences in HRV values were noted between patients with a history of syncope and positive or negative result of TT. Upright tilt resulted in HRV changes of the same direction and value in syncopal patients in the POS and NEG goup, as well as in patients in the CG_NEG group. Conclusion HRV values and changes of those values at subsequent stages of TT were not different between syncopal patients with postive or negative TT result, or negative TT control group. The Italian protocol of TT may be associated with a surprisingly high percentage of false positive results.
EN
The complex pathogenesis of cyclophosphamide-induced hemorrhagic cystitis involves arachidonic acid-derived inflammatory mediators, among them leukotrienes. Montelukast, a leukotriene receptor antagonist, is reported to exert an alleviatory effect in the course of cystitis associated with overactive bladder symptoms. The aim of this study was to verify whether the effect of montelukast is also associated with its influence on autonomic activity. The experiment included 20 rats with cyclophosphamide-induced hemorrhagic cystitis (75 mg/kg, four doses every second day), among them, 10 treated with oral montelukast (10 mg/kg for 8 days) and 10 controls. Time and frequency domain analyses of heart rate variability (HRV) were conducted in all the rats as an indirect measure of their autonomic activity. The montelukast-treated animals showed an increase in root mean square of successive differences (rMSSD), as well as an increase in HRV spectrum total power (TP) and power of very low (VLF) spectral component. This suggests that due to its anti-inflammatory and its anti-leukotriene effect, montelukast improves overall autonomic activity, with no preferential influence on either the sympathetic or parasympathetic part. Furthermore, the increase in VLF corresponds to attenuation of inflammatory response. In conclusion, this study showed that aside from its antagonistic effect on leukotriene receptors, montelukast can also modulate autonomic activity.
8
Content available remote Personal wearable monitor of the heart rate variability
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EN
The aim of the paper is to present a prototype of wearable heart rate variability (HRV) monitor. The home care surveillance and sleep assessment system is partly embedded into a smart home infrastructure and partly worn by a supervised person. The prototype wearable device is designed to acquire and process the electrocardiogram and to send reports accordingly to a programmed schedule. The recording, processing and transmission modes are programmable, what allows the recorder to respond immediately in case of predefined thresholds excess, while the regular reporting is organized in delayed packets exchanged during a short transmission session. This approach significantly reduces the contribution to the total power consumption from the communication module. The prototype was based on the PXA-270 development kit, but due to very low power consumption (0,5 mW) the migration to a more compact system is considered.
EN
Introduction: Syncope is defined as transient loss of consciousness, due to decrease in brain perfusion. The most frequent mechanism is vasovagal syncope. In many patients, the cause of syncope remains unspecified, despite an extensive diagnostic work-up. Tilt-test (TT) is an acknowledged diagnostic tool for syncope. Currently, the so-called Italian protocol of TT is most widely used. Vasovagal syncope is caused by impaired circulatory regulation in response to orthostatic stress. One of the available tools to examine the influence of the nervous system on the circulation is the analysis of heart rate variability (HRV). Despite numerous publications concerning HRV parameters and autonomic regulation in patients with syncope, direct comparisons and metaanalysis of the results is impossible, due to variability of TT protocols and study group specifications. Aim of the study: As there is no uniform model of HRV during TT, we aimed to analyze HRV parameters during TT (performed according to the Italian protocol) in patients with vasovagal syncope, in order to determine the possible application of HRV measurements in clinical practice in that group of patients. Detailed objectives were: (1) analysis and comparison of HRV in patients with and without the history of syncope; (2) analysis of HRV changes in consecutive stages of TT; (3) identification of possible HRV differences between patients with positive and negative TT results. Materials and methods: Patients between 18 and 50 years of age were qualified for the study, if they had a history of at least 2 incidents of syncope or presyncope within the preceeding 6 months, and if signs and symptoms indicated the vasovagal mechanism. The study group included 150 patients: 100 consecutive patients with a postive TT result (POS), and 50 consecutive patients with a negative TT result (NEG). The control group (CG) comprised 50 volunteers with no history of syncope nor presyncope, matched according to age and sex to the study group. In all patients a TT was performed according to the Italian protocol, with paced breathing at a rate of 15/min. Time-domain (meanRR, SDNN, RMSSD, pNN50) and frequency-domain (abs_LF, abs_HF, rel_LF, rel_HF, norm_LF, norm_HF, LF/HF) HRV parameters were analyzed and compared at different stages of TT in the study groups as specified above. Results: 100 patients at the age of 18-44 years were included in the POS group, 50 patients at the age of 18-39 years in the NEG group, and 50 volunteers at the age of 20-39 in the CG. Volunteers in the control group developed unexpectedly high percentage of positive TT (14 patients). For consistency of analysis, the CG was thus subdivided according to the result of the TT into CG_POS (positive result of TT) – 14 patients, and CG_NEG (negative result of TT) – 36 patients. Based on HRV analaysis, no significant differences in HRV values were noted between patients with a history of syncope and positive or negative result of TT. Upright tilt resulted in HRV changes of the same direction and value in syncopal patients in the POS and NEG goup, as well as in patients in the CG_NEG group. Conclusion: HRV values and changes of those values at subsequent stages of TT were not different between syncopal patients with postive or negative TT result, or negative TT control group. The Italian protocol of TT may be associated with a surprisingly high percentage of false positive results.
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We demonstrate the resonant-like behaviour of the cardiopulmonary system in healthy people occurring at the natural low frequency oscillations of 0.1 Hz, which are often visible in the continuous pressure waveform. These oscillations represent the spontaneous oscillatory activity of the vasomotor centre and are sometimes called the Mayer waves. These 10-second rhythms probably couple with forced breathing at the same frequency and cause the observed cardiopulmonary resonance phenomenon. We develop a new method to study this phenomenon, namely the averaged Lomb-Scargle periodogram method, which is shown to be very effective in enhancing common frequencies in a group of different time series and suppressing those which vary between datasets. Using this method we show that in cardiopulmonary resonance the cardiopulmonary system behaves in a very similar way to a simple mechanical or electrical oscillator, i.e. becomes highly regular and its averaged spectrum exhibits a clear dominant peak and harmonics. If the forcing frequency is higher than 0.1 Hz, the total power and the share of power in the dominant peak and harmonics are lower and the prominence of the dominant peak and its harmonics greatly diminishes. It is shown that the power contributions from different forcing frequencies follow the resonance curve.
EN
The goal of the study was to determine the effect of a 1-h hour long forklift truck virtual simulator driving on the mechanism of autonomic heart rate (HR) regulation in operators. The participants were divided into 2 subgroups: subjects with no definite inclination to motion sickness (group A) and subjects with a definite inclination to motion sickness (group B). Holter monitoring of electrocardiogram (ECG) signal was carried out in all subjects during the virtual simulator driving. For 12 consecutive epochs of ECG signal, HR variability analysis was conducted in time and frequency domains. In subjects with a definite inclination to motion sickness after ~30 min of the driving, changes in parameter values were found indicating an increase in sympathetic and parasympathetic activity with parasympathetic dominance.
EN
Technique for separate estimation of fast and slow fluctuations in the heart rate signal is developed. The orthogonal dyadic wavelet transform is used to separate the slow heart rate changes in approximation part of decomposition and fast changes in detail parts. Experimental results using the recordings from persons practicing Chi meditation demonstrated the applicability of estimation heart rate fluctuations with the proposed approach.
EN
Background: The efectiveness of the vegetative regulation action might be controlled by the method of heart rate variability (HRV), which has been very popularly used over the last 10 years worldwide. The analysis of many clinical studies indicates that the severity of the disease might be controlled using the method of HRV. Material and methods: All the experimental and controlled group participants, which consisted of healthy students with none sports experience, underwent the examination according to the 5-minute standard protocol of HRV. In addition, all the examinees performed a bicycle stress test. After the bicycle stress test, some additional tests of HRV were also carried out. Results: It was found that some signifcant diferences, between the group of sportsmen and the group of patients, exist. The parasympathetic activity of LF is maximum in athletes and tends to decrease in patients with cardiovascular pathologies. The decreases of the activity of the vasomotor centre was noticed in both study groups. The sympathetic system activity was the lowest in athletes. Conclusions: At the high depression of the vegetative regulation, any signifcant load (physical or psycho-emotional) indicates cardiovascular instability which remains beyond the capacity of adaptation. The higher the variability, the more stable the CVS is to the external loads. A sharp decrease of the variability, such as the heart vegetative innervations, causes deteriorating quality of the regulatory mechanisms and, as a result, the risk of cardiovascular diseases increases.
PL
Wstęp: Skuteczność działania wegetatywnej regulacji może być kontrolowana przy pomocy oceny zmienności rytmu serca (HRV). Metoda ta przez ostatnie 10 lat zyskała popularność na całym świecie. Analiza licznych obserwacji klinicznych wskazuje, że nasilenie choroby można kontrolować przy użyciu HRV. Materiał i metody: Wśród wszystkich uczestników badania zarówno z grupy eksperymentalnej, jak i kontrolnej (zdrowi studenci bez dużych obciążeń sportowych) w spoczynku przeprowadzono badanie według standardowego protokołu 5-minutowego HRV. Dodatkowo wszyscy badani wykonali próbę ergometryczną (protokół standardowy i stochastyczny). 5-10 minut po wysiłku przeprowadzono dodatkowe testy HRV. Wyniki: Ustalono, że istnieją znaczne różnice pomiędzy grupą kontrolna a grupą pacjentów z chorobami serca. Zanotowana aktywność działania układu przywspółczulnego była maksymalna u przedstawicieli grupy kontrolnej i zmniejszyła się u pacjentów z patologią sercowo-naczyniową. Stwierdzono zmniejszenie aktywności ośrodka naczynioruchowego we wszystkich grupach badanych. Aktywność działania układu współczulnego u sportowców była najniższa. Wnioski: Przy obniżeniu wegetatywnej regulacji każde znaczące obciążenie (fzyczne, psycho-emocjonalne) wskazuje na strefę niestabilności sercowo-naczyniowej, co jest poza możliwością adaptacji. Większa zmienność rytmu – to wskaźnik stabilnej pracy serca przy obciążeniach zewnętrznych. Gwałtowny spadek zmienności rytmu, tj. „autonomiczne unerwienie serca”, to wskaźnik pogarszającej się jakości mechanizmów regulacyjnych, w wyniku czego zwiększa się ryzyko chorób ser- cowo-naczyniowych.
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Content available remote Heart rate variability assessment with rational-dilation wavelet transform
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EN
Wavelet transform on a rational dilation is proposed as a method of assessment of spectral power in low and high frequency (LF and HF, respectively) bands for heart rate variability (HRV) analysis. One of the unique properties of this method is a possibility to align the band limits of certain scales with the limits of ranges LF and HF used in HRV analysis. The method parameters are optimized for use in the context of HRV analysis. Suitable examples are tilt test recordings analyzed using the optimized rational-dilation wavelet transform method.
EN
The purpose of the article was to determine the functional state of the cardiorespiratory system and the vegetative regulation of the heart rhythm of male students engaged in the sports-pedagogical perfection groups on boxing when performing the dose-related physical exertion. To implement the goal, the following research methods were used: photoplethysmography, heart rate variability (HRV), cardiointervalography, spirography, tonometry, veloergometry, methods of mathematical statistics. Thus, with comparatively the same relative values of the results of the PWC170 sample, the boxer students of all weight categories, the sympathetic regulation of cardiovascular activity is dominant, which indicates the same tropic support for performing physical exertion. During the restitution period, there is a decrease in the frequency-volume parameters of the respiratory system, to a greater extent, due to the frequency of the respiratory cycles. The centralization index (according to R. M. Baievskyi) remains unrefined in comparison with the results of the sample, while maintaining a tendency to dominate the “heavyweights” of sympathicotonia balance. In this case, the ratio of low-wave to high-wave components of HRV (LF) indicates the dominance of sympathetic regulation of cardiovascular activity of boxer students of all weight categories. It is typical that students-boxers of heavy weight categories have a fairly low overall absolute level of regulatory systems activity, the LF/HF ratio is in the low-wave range, which indicates a low adaptation of the regulation of cardiac activity of boxer heavy students to submaximal load. Since the PWC170 sample is performed mainly in submaximal mode, which is characteristic for lightweight boxers and is non-specific for heavyweights, it is logical that the under-recovery of the trophic (oxygen) function in boxing students in heavy categories is due to the low functionality of the organism to the glycolytic regime of power supply.
EN
We apply the dynamic decomposition of Poincaré plots, which is a computationally intensive, visual method of analysing physiological time series, to the analysis of the interbeat interval variability, systolic blood pressure, stroke volume and total peripheral resistance which were simultaneously recorded from a patient with pheochromocytoma and rapid, repetitive haemodynamic changes over 6 hours. The resulting animation is analysed and interpreted. It is found that changes in total peripheral resistance usually precede those of other variables, and the magnitude of changes is greatest for this variable. It is demonstrated that the decomposition of Poincaré plots of multivariate signals can visualise both the order and the extent of ongoing instant changes.
EN
The study on cognitive workload is a field of research of high interest in the digital society. The implementation of ‘Industry 4.0’ paradigm asks the smart operators in the digital factory to accomplish more ‘cognitive-oriented’ than ‘physical-oriented’ tasks. The Authors propose an analytical model in the information theory framework to estimate the cognitive workload of operators. In the model, subjective and physiological measures are adopted to measure the work load. The former refers to NASA-TLX test expressing subjective perceived work load. The latter adopts Heart Rate Variability (HRV) of individuals as an objective indirect measure of the work load. Subjective and physiological measures have been obtained by experiments on a sample subjects. Subjects were asked to accomplish standardized tasks with different cognitive loads according to the ‘n-back’ test procedure defined in literature. Results obtained showed potentialities and limits of the analytical model proposed as well as of the experimental subjective and physiological measures adopted. Research findings pave the way for future developments.
EN
This study was aimed to demonstrate the efficacy of interval hypoxic training (IHT) in complex treatment of Helicobacter pylori-associated duodenal peptic ulcer disease (DPUD) by parameters of aerobic metabolism and indexes of heart rate variability (HRV). Eighty patients with H. pylori-associated DPUD were included into the study, mean age 32±1.8 yrs, duration of the disease up to 10 years (66.3 %). IHT was modulated using Frolov's hypoxicator (TDI-01) for 30 days after standard eradication therapy. Daily hypoxic sessions consisted of three one-minute sessions, one two-minute, and one three-minute sessions separated by one-minute intervals of room-air breathing. Use of IHT resulted in more efficient elimination of clinical symptoms, histological hallmarks of inflammation and signs of oxidative stress in glandulocytes of the gastric mucosa as determined by 4-hydroxynonenal accumulation. Moderate prooxidant activity of IHT was demonstrated by the increased level of TBARS and oxidatively modified products, normalization of hydroperoxides, middle mass molecules and atherogenic beta-lipoproteins with simultaneous increase in catalase activity and mild decline of SOD activity. Therefore, IHT appeared to be accompanied by higher intensity of redox reactions and enhanced regeneratory processes in cells and tissues. Significant increase in HRV was also noted. Such changes were associated with reduction of inflammation signs and modulation of the autonomic homeostasis in DPUD patients. In general, use of IHT in complex treatment of H. pylori in DPUD patients can be recommended to increase resistance to oxidative stress and to modulate autonomic balance and oxidative homeostasis.
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