Wyniki wyszukiwania - Biblioteka Nauki

1

Comparison of chemical composition and biological activities of Seseli rigidum fruit essential oils from Serbia

100%

Ilić M. D. , Jovanović V. P. S. , Mitić V. D. , Jovanović O. P. , Mihajilov-Krstev T. M. , Marković M. S. , Stojanović G. S.

Open Chemistry

|

2015

|

tom 13

|

nr 1

EN

Plants from genus Seseli, have been widely used in European traditional medicine, exhibiting antibacterial, antifungal, insect repellent, emmenogogue, antiflatulence, anti-inflammatory, antinociceptive, anti-tumor, antirheumatic activities and protective effect on human lymphocytes DNA. They usually grow on mountain rocky terrains. Part of their habitat on Vidlic Mountain, located in South-east Serbia, was struck with a large wildfire. Seseli rigidum fruit essential oils (from post fire and control areas) compositions were analyzed by GC and GC-MS, identifying monoterpenes α-pinene and sabinene as most abundant. Statistical tests showed a non-significant difference in chemical composition of these two oils, but a significant difference in comparison with the herb from a geographically different origin. Antimicrobial tests showed strong activities of the oils against tested bacteria, thus confirming its administration in various inflammation processes as a quite effective remedy. Applying DPPH. and ABTS+. radical scavenging and total reducing Fe(III) to Fe(II) power assays, antioxidant characteristics of both studied essential oils were estimated as weak, though of close values. Seseli rigidum fruit essential oil was proven as a potent inhibitor of human and horse serum cholinesterase, recognizing its possible application as neural protective agent

2

Antioxidant effects of carotenoids in a model pigment-protein complex

100%

Fiedor J. , Sulikowska A. , Orzechowska A. , Fiedor L. , Burda K.

|

2012

|

tom 59

|

nr 1

61-64

EN

The effect of carotenoids on stability of model photosynthetic pigment-protein complexes subjected to chemical oxidation with hydrogen peroxide or potassium ferricyanide was investigated. The oxidation of carotenoid-less and carotenoid-containing complexes was conducted in the presence or absence of ascorbic acid. The progress of the reactions was monitored by use of absorption and fluorescence spectroscopy. Our results show that carotenoids may significantly enhance the stability of photosynthetic complexes against oxidation and their protective (antioxidant) effect depends on the type of the oxidant.

3

Can angiotensin-converting enzyme inhibitors interfere with the free radicals? Measurement of antioxidant capacity using DPPH radical reduction examined by UV-VIS method

100%

Ramos P. , Juszczak A. , Szczołko W. , Pilawa B. , Stanisz B. J.

|

nr 2

233-239

EN

A negative impact of radicals on human’s health is responsible for growing research interest in antioxidant properties of substances, which protect organisms from the damaging influence of these reactive species. Angiotensin-converting enzyme inhibitors (ACE-I) are the most popular drugs used in cardiovascular diseases. There are a lot of clinical reports that ACE-I have antioxidant properties, due to the fact, that prolonged use improves conditions of patients with neurodegenerative disorders and slow inflammatory processes. The paper shows the antioxidant properties of a selected ACE-I: cilazapril, ramipril, imidapril, lisinopril, perindopril, and quinapril. Among numerous methods for antioxidant activity estimation, DPPH reduction is the most popular and commonly used one due to its ease, speed, sensitivity and the usage of stable radicals. UV-Vis spectrophotometry was used to examine interactions of chosen ACE-I with model-free radicals. Absorption of UV-Vis spectra of DPPH (reference), and DPPH interacting with the tested ACE-I were compared. For all tested ACE-I kinetics of their interaction with DPPH, up to 30 minutes, were obtained. The strongest interaction with DPPH was observed for imidapril and cilazapril and the lowest interaction for lisinopril. Studies have shown usefulness UV-Vis spectrophotometry for obtaining information on interactions of ACE-I with model-free radicals.

4

Phytoconstitution and Antioxidant Activity of the Ethanolic Extract of an Antimalarial Herbal Mixture

100%

Odokwo E. O. , Onifade M. S.

World News of Natural Sciences

|

2024

|

tom 54

38-44

EN

The phytoconstitution and antioxidant profiling of mixture of herbs used in the treatment of malaria has been carried out. Herbs used as alternative medicines in the local treatment of malaria were collected from a herbal vendor in Ibadan. The herbal materials were extracted using absolute ethanol and the crude extract, EEA subjected to qualitative phytochemical screening and 2,2-diphenyl-1-picrylhydrazyl (DPPH) standard procedures. The presence of alkaloids, saponins, tannins, terpeniods, flavonoids and phenols were identified. EEA was found to exhibit antioxidant activity in the dose range of 25-400 μgml-1. The significant presence of major series of phytochemicals has justified the associated antimalarial ethnomedicinal claim. Thus, the present study has established the phytoconstitution and antioxidant activity of an antimalaria herbal mixture.

5

Przeciwutleniacze w technologii elastomerów

100%

Masek A. , Zaborski M.

|

tom [R.] 17, nr 5

344-346

PL

W celu ochrony wyrobów gumowych dodaje się na etapie przetwórstwa substancje przeciwstarzeniowe. Obecnie na skalę przemysłową stosuje się aminy aromatyczne, syntetyczne polifenole. Jednak współczesne trendy narzucają pewne normy zgodne z etyką ekologiczną. Zatem wydaje się, że należy poszukiwać nowych naturalnych przeciwutleniaczy, w pełni przyjaznych dla środowiska naturalnego. Niewątpliwie w taką grupę wpisują się naturalne polifenole syntezowane przez rośliny. Zaproponowane przez nas antyoksydanty mogą być ciekawą alternatywą dla przemysłu.

EN

In the objective of protection of rubber products at the stage of the processing substances are being added antioxidants. At present on an industrial scale an aromatic amine and synthetic polyphenols are applied. However contemporary trends are imposing certain norms in accordance with environmental ethics. And so it seems that one should discovery new natural and ecofriendly antiageing substances. Undoubtedly natural polyphenols are becoming part of such a group synthesize through plants. Antioxidants offered by us can be an interesting alternative to the industry.

6

The construction of coenzyme Q-containing vesicles

100%

Grzybek M. , Stebelska K. , Sikorski A. F.

|

nr Suppl.

7

Coenzyme Q: a bioenergetic and antioxidant compound

100%

Lenaz G.

|

nr 5

8

Antioxidant properties of fruits of raspberry and blackberry grown in central Europe

88%

Kostecka-Gugała A. , Ledwożyw-Smoleń I. , Augustynowicz J. , Wyżgolik G. , Kruczek M. , Kaszycki P.

Open Chemistry

|

2015

|

tom 13

|

nr 1

EN

Fruits of several, mainly Polish cultivars of floricane- and primocane-fruiting red raspberry (Rubus idaeus), black raspberry (Rubus occidentalis) and blackberry (Rubus fruticosus), grown in central Europe during two successive vegetation periods, were investigated. The content of phenolic compounds, including anthocyanins, as well as antioxidant properties of fruit extracts were analysed. A number of methods were employed: ferric ion reducing antioxidant power (FRAP), cupric ion reducing antioxidant capacity (CUPRAC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity involving both colorimetric and EPR spectrometric measurements. From among all the tested fruits black raspberries had the largest antioxidant capacity as verified by all methods used in this study. These berries were also the most abundant in phenolic and anthocyanin compounds. Blackberries were characterised by larger antioxidant capacity than red raspberry fruits which were accompanied by higher content of total phenolics and anthocyanins. Berries of primocane-fruiting cultivars, often used for intensive agricultural production, generally did not differ in the total phenolic and anthocyanin content as well as in the antioxidant capacity as compared to the traditional, floricane-fruiting ones. The research contributes to deep characterisation of central European berry fruits which due to their high content and large diversity of health-beneficial compounds are classified as natural functional food.

9

Lycopene as a guardian of redox signalling

88%

Palozza P. , Catalano A. , Simone R. , Cittadini A.

|

2012

|

tom 59

|

nr 1

21-25

EN

It has been suggested that lycopene, the major carotenoid found in tomato, exhibits health-beneficial effects by virtue of its antioxidant activity. However, recent literature suggests that lycopene can actually "perform" roles independent of such capacity and involving a direct modulation of redox signalling. Reactive oxygen species are known to act as second messengers in the modulation of cellular signalling leading to gene expression changes and pharmacological responses. Lycopene may control redox-sensitive molecular targets, affecting enzyme activities and expressions and modulating the activation of MAPKs and transcription factors, such as NF-κB and AP-1, Nrf2.

10

Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions

88%

Reiter R. J. , Tan D.-x. , Pilar Terron M. , Flores L. J. , Czarnocki Z.

|

2007

|

tom 54

|

nr 1

1-9

EN

This review summarizes some of the recent findings concerning the long-held tenet that the enzyme, N-acetyltransferase, which is involved in the production of N-acetylserotonin, the immediate precursor of melatonin, may in fact not always control the quantity of melatonin generated. New evidence from several different laboratories indicates that hydroxyindole-O-methyltransferase, which O-methylates N-acetylserotonin to melatonin may be rate-limiting in some cases. Also, the review makes the point that melatonin's actions are uncommonly widespread in organs due to the fact that it works via membrane receptors, nuclear receptors/binding sites and receptor-independent mechanisms, i.e., the direct scavenging of free radicals. Finally, the review briefly summarizes the actions of melatonin and its metabolites in the detoxification of oxygen and nitrogen-based free radicals and related non-radical products. Via these multiple processes, melatonin is capable of influencing the metabolism of every cell in the organism.

11

In silico screening, synthesis, in vitro evaluations antibacterial and DPPH scavenging activity of some 1,3,5-trisubstituted 2-pyrazoline derivatives as dihydrofolate reductase inhibitors

88%

Suriya S. , Mala V.

|

tom 18

|

nr 2

180-186

EN

In this work, synthesis of three pyrazoline derivatives (6-8) is described. (E)-1,3-(phenylsubstituted)-prop-2-en-1-one (3-5) is prepared by the reaction of substituted benzaldehyde with 4-methylacetophenone, whereas condensation cyclization of the same chalcones (3-5) with phenylhydrazine hydrate in ethanol yielded 6-8. The structures of the title compounds (6-8) were characterized by chemical reactions, elemental analysis, and spectral methods such as IR spectra. The synthesized chalcone and pyrazolines were evaluated for in-vitro antibacterial and antioxidant activities against standard. The zone of inhibition for some of the newly synthesized compounds showed notable antibacterial activity against selected bacterial strains when compared with ampicillin. Significant antioxidant activities were also shown by chalcone and pyrazolines.

12

Current concepts in pathophysiology and management of hepatocellular carcinoma

88%

Hamza A. , Abdulfattah H. , Mahmoud R. , Khalil W. , Ahmed H.

|

tom 62

|

nr 3

573-580

EN

Additional approaches to control malignancies are needed due to the emerging trends in the incidence of cancer of different organ sites. Due to the high frequency of hepatocellular carcinoma (HCC) and its poor prognosis, preventing HCC is an urgent priority. To explore the antioxidant and apoptotic pathways of grape seed extract (GSE) we induce HCC experimentally by diethylnitrosoamine (DEN) and treated the animals with low and high doses of GSE. The results indicate good therapeutic possibilities for GSE use in treatment of HCC., This was evidenced via regression of liver enzymes' function (ALT&AST), the HCC markers; α-fucosidase, α-fetoprotein and carcinoembrionic antigen (CEA) in HCC groups treated with the grape seed extract. Also, tumor necrosis factor (TNF-α) showed a significant decrease using GSE in HCC bearing animals. Regarding the apoptotic pathways of GSE, we found a significant down regulation of apoptosis enhancing nuclease (Aen), Bcl2-associated X protein (Bax), B-cell translocation gene 2(Btg2), Cyclin G1 (Ccng1) and Cyclin-dependent kinase inhibitor 1A (Cdkn1a) gene expression in HCC+GSE groups as compared to HCC bearing group. In the same trend, the necrotic/apoptotic rates were significantly higher in the HCC groups treated with GSE vs. the HCC bearing group. Finally, the 8-OHdG/2-dG generation decreased by 73.8% and 52.9% in HCC+GSE at low and high doses, respectively. Based on these encouraging observations, grape seed extract could be a promising natural remedy for attenuating hepatocellular carcinoma that has a great future in approaches directed towards control of HCC.

13

Nutritional Composition, Minerals, Vitamin C and Antioxidant Analysis of Yellow Mombin (Spondias mombin L.) Nut

88%

Odokwo E. O. , Uzoekwe N. M.

|

tom 53

86-93

EN

The nutritional, mineral, Vitamin C and antioxidant capacity profiling of the nut of Spondias mombin has been carried out. The nut of S. mombin (NSM) was extracted from its fruit and then profiled quantitatively for its nutritional, mineral and vitamin C contents using the AOAC standard procedures. The antioxidant capacity of the methanol extract of NSM was carried out using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay and ferric reducing antioxidant potential (FRAP) techniques. The nut was found to have nutritional facts of: moisture content (12.24±0.06%), lipid content (1.69±0.01%), fibre content (45.27±0.32%), protein content (5.69±0.04%), ash content (0.41±0.02%) and carbohydrate content (34.70±0.33%). The mineral content in mg/g of sample was found to contain: K (7.014), Na (2.966), Ca (1.333), Mg (0.690), Fe (0.131), Cu (0.079), Zn (0.015), Cd (0.004) and Cr (0.009). Pb was not detected. The vitamin C content was 3.89 mg, DPPH antioxidant potential increases as concentration of NSM increases from 25.00 µg/ml to 400 µg/mL and FRAP was observed at 400 μg/ml NSM to be 75.304±0.002 mgAAE. The nut of S. mombin has shown to be good sources for alternative nutrition and as a base for minerals rich in cellular ions. The nut of S. mombin has exhibited antioxidant capacity which can be attributed to the presence of some vital phytoconstituents.

14

TLC-DPPH• activity-guided separation and LC-DAD-MS identification of antioxidant compounds from Mutellina purpurea L. herb

88%

Sieniawska E. , Baj T. , Dudka J. , Mroczek T. , Głowniak K.

|

tom Vol. 28, no. 1

51--58

EN

Many phytochemical investigations have been focused recently on the antioxidant activity of herbal extracts which can be used in phytotherapy. The previous study revealed antioxidative properties of Mutellina purpurea extract, but the constituents responsible for this action were not described yet. The aim of this study was activityguided separation and identification of antioxidant compounds from M. purpurea herb. Thin-layer chromatography-2,2-diphenyl-1-picrylhydrazyl (TLC-DPPH•) assay was used to detect compounds of interest; liquid chromatography-diode array detection-mass spectrometry (LC-DAD-MS) analysis allowed to identify antioxidants. The active fractions analyzed with LC-DAD-MS contained as a main compound chlorogenic acid accompanied with p-coumaric acid, ferulic acid, three dicaffeoylquinic acids, and caffeoylferuloylquinic acid. The fast TLC-DPPH• assay with LC-DAD-MS identification enabled the accurate identification of antioxidants in M. purpurea herb, which was done for the first time.

15

Protective effects of cassia seed ethanol extract against carbon tetrachloride-induced liver injury in mice

88%

Xie Q. , Guo F.-F. , Zhou W.

|

2012

|

tom 59

|

nr 2

265-270

EN

Oxidative stress has been recognized as a critical pathogenetic mechanism for the initiation and the progression of hepatic injury in a variety of liver disorders. Antioxidants, including many natural compounds or extracts, have been used to cope with liver disorders. The present study was designed to investigate the hepatoprotective effects of cassia seed ethanol extract (CSE) in carbon tetrachloride (CCl4)-induced liver injury in mice. The animals were pre-treated with different doses of CSE (0.5, 1.0, 2.0 g/kg body weight) or distilled water for 5 days, then were injected intraperitoneally with CCl4 (0.1% in corn oil, v/v, 20 ml/kg body weight), and sacrificed at 16 hours after CCl4 exposure. The serum aminotransferase activities, histopathological changes, hepatic and mitochondrial antioxidant indexes, and cytochrome P450 2E1 (CYP2E1) activities were examined. Consistent with previous studies, acute CCl4 administration caused great lesion to the liver, shown by the elevation of the serum aminotransferase activities, mitochondria membrane permeability transition (MPT), and the ballooning degeneration of hepatocytes. However, these adverse effects were all significantly inhibited by CSE pretreatment. CCl4-induced decrease of the CYP2E1 activity was dose-dependently inhibited by CSE pretreatment. Furthermore, CSE dramatically decreased the hepatic and mitochondrial malondialdehyde (MDA) levels, increased the hepatic and mitochondrial glutathione (GSH) levels, and restored the activities of superoxide dismutase (SOD), glutathione reductase (GR), and glutathione S-transferase (GST). These results suggested that CSE could protect mice against CCl4-induced liver injury via enhancement of the antioxidant capacity.

16

Antioxidant properties of Artemisia absinthium accelerate healing of experimental Achilles tendon injury in rabbits

88%

Hoseinian A. , Moslemi H. R. , Sedaghat R.

|

nr 1

EN

Delayed tendon healing is still found to be among the complications that occur most often after tendon repair. The role of local injection of Artemisia absinthium was evaluated in healing of experimental Achilles tendon injury in rabbits. In nine adult New Zealand rabbits a partial thickness tenotomy was created on both hindlimbs. A. absinthium extract and normal saline were respectively injected daily to treatment and control groups for three days. On the day 7 after injury, the tendon sections showed that healing rate in A. absinthium treated group was higher than that in control group. Furthermore, at days 14 and 28, comparison between A. absinthium treated group and control group demonstrated that A. absinthium increased the healing rate but with no significance. Results of this study have showed that application of A. absinthium extract can improve healing process of damaged Achilles tendon.

PL

Powolne gojenie jest jedną z komplikacji pojawiających się najczęściej po operacji odbudowy ścięgna. Badano wpływ miejscowego podania Artemisia absinthium w iniekcji na gojenie doświadczalnego uszkodzenia ścięgna Achillesa u królików. U dziewięciu dorosłych królików nowozelandzkich przeprowadzono częściową tenotomię ścięgien obu kończyn tylnych. Następnie podawano w iniekcji wyciąg z A. absinthium lub sól fizjologiczną odpowiednio w grupie doświadczalnej i w grupie kontrolnej przez trzy dni.Siódmego dnia po uszkodzeniu okazało się, że tempo gojenia w grupie leczonej wyciągiem z A. absinthium było wyższe niż w grupie kontrolnej. Co więcej, porównanie przeprowadzone 14. i 28. dnia wykazało, że podanie A. absinthium przyspieszyło gojenie, ale nieistotnie.Wyniki tego badania pokazują, że podanie wyciągu z A. absinthium może przyspieszyć process gojenia uszkodzonego ścięgna Achillesa.

17

Resveratrol and curcumin against diabetic retinopathy. Better together than apart

88%

Kabiesz A.

|

nr 4

284-288

EN

The health-promoting effects of curcumin and resveratrol have been known for a long time. The most important features of polyphenols include their effect on blood vessels and participation in the neutralization of free oxygen radicals. Both resveratrol and curcumin exhibit antioxidant effects, and the combined use of both substances significantly improves their effectiveness. In the fight against diabetic retinopathy, the antiangiogenic effect of polyphenols also turn out to be important. Many researchers also point to the possibility of using resveratrol and curcumin in cancer therapy.

18

The antioxidant and antibacterial activities of the essential oils of Marrubium vulgare growing wild in Eastern Algeria

88%

Abadi A. , Abdellatif F.

|

tom Vol. 10, iss. 2

159-166

EN

The chemical composition was analyzed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). The constituents were identified by their mass spectra and Kovats’ indices. Fivety (50) components in the oil of M. vulgare were identified. The results demonstrated that the major components of the essential oil were : 4,8,12,16-Tetramethyl heptadecan-4-olid (16.97 %), Germacrene D-4-ol (9.61 %), α- pinéne (9.37 %), Phytol (4.87 %), Dehydro-sabina ketone (4.12 %), Piperitone (3.27 %), δ-Cadinene (3.13 %), 1-Octen-3-ol (2.35 %) and Benzaldehyde (2.31 %). The antioxidant activity of the oils was assessed by measurement of metal chelating activity, the reductive potential, the free radical scavenging (DPPH) assay. The antioxidant activity was compared with that of synthetic antioxidants: butylated hydroxyanisole (BHT) , and the essential oils . The results showed as the Essential oil of M vulgare was evaluated for its antibacterial activities against Gram-positive and Gram negative pathogenic bacteria: Listeria monocytogene, Pseudomonas aeruginosa , Agrobacterium tumefaciens and Salmonella enterica.

19

Some bioactive properties of Acacia dealbata extracts and their potential utilization in wood protection

88%

Yildiz S. , Gürgen A. , Can Z. , Tabbouche S. A. , Kiliç A. O.

|

2018

|

tom vol. 61, nr 202

81--97

EN

A study was made of the potential use of Acacia dealbata wood extracts as bioprotective agents. Initially, extracts were obtained from Acacia dealbata sapwood, heartwood and bark, and their antioxidant, antimicrobial and anti-quorum sensing activities were determined. Next, the decay resistance of Scots pine wood samples impregnated with these extracts was examined against the brown rot fungus, Coniophora puteana. The impregnation procedure was performed according to the ASTM D (1413) standard test method at two different concentrations, 3% and 5% by weight, using hot water and methanol as extraction solvents. The strongest antioxidant, antimicrobial and anti-quorum sensing activities were those of the bark extract. Hot water extraction led to lower performance than methanol extraction. According to EN 113 testing methods, the highest level of preservative effect against wood-decaying fungi was observed in the case of 5% methanol extract from the bark.

20

Investigation of the Antioxidant and Anti-Inflammatory Capacities of Different Extracts from Cistus ladanifer L. Leaves in the Ait Ammart Region (Northern Morocco)

88%

Benamari O. , Labhar A. , Ahidar N. , Salhi A. , Ahari M. h. , Elyoussfi A. , Benyoub B. , Amhamdi H.

|

tom Vol. 25, iss. 3

178--184

EN

Plants are a significant source for identifying new compounds (particularly secondary metabolites) with medicinal value for drug development, pharmaceuticals, and food additives. Many of these healing plants are frequently used in conventional medicine to treat and prevent various diseases. The purpose of the current research is to assess the total phenolic content (TPC) and total flavonoid content (TFC) for phytochemical analysis, DPPH and FRAP (Ferric Reducing Antioxidant Power) assays for antioxidant activity (AOA), and the activity of reducing inflammation exhibited by various extracts, which were determined by measurement of absorbance with a UV spectrophotometer. The outcome demonstrated that the Cistus ladanifer L leaf aqueous extract (EAqCL) has the highest yield (15.581%) and the highest phenolic content (98.28 ± 0.32 mg GAE/gext) compared to the other extracts. Whereas, ethanol extract (EECL) exhibited the highest flavonoid content (11.39 ± 1.45 mg QE/gext), DPPH-radical scavenging activity (RSA = 94.534 ± 1.24%) at 800 μg/ml and FRAP (1.017 ± 0.12) at 400 μg/mL. The extract also showed better anti-inflammatory activity (95.61 ± 0.92%) at 1000 μg/ml. According to the results obtained, this sticky shrub growing in the Ait Ammart region has great potential for exploiting natural sources of bioactive substances and producing pharmacologically active metabolites.