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The aim of this study is to investigate the in vitro antimicrobial activity of Ankaferd Blood Stopper® against methicillin-resistant Staphylococcus aureus (MRSA), Enterococcus species, Escherichia coli, Pseudomonas species, Acinetobacter species and Klebsiella species of nosocomial origin. Ankaferd inhibited growth in 72.4% to 100% of the bacteria tested, depending on the type of the isolate. As a result, it can be stated that Ankaferd inhibits the in vitro growth of nosocomial bacteria. This is a novel, important finding since severe hospital infections coexist with many hemostatic disorders, and the use of Ankaferd may increase hemostatic potential in such clinical conditions.
Two novel complexes, [La(HL)(H2O)2NO3] · NO3 · H2O and [Gd(HL)(H2O)2NO3] · NO3 · H2O, where HL is a Schiff base derived from o-vanillin and lysine, have been synthesized and characterized by elemental analysis, conductivity measurements, IR, 1H NMR and thermogravimetric analyses (TGA). The Schiff base ligand behaves as a tetradentate, coordinating through azomethine nitrogen, phenolic oxygen and two carboxylic oxygen atoms. The interaction of these complexes with calf thymus DNA (CT-DNA) was also investigated by spectrometric titration and viscometric measurements. The faint hypochromism of the complexes in the absorption spectra, the remarkable reduction of fluorescence intensity of ethidium bromide (EB) bound DNA, together with a small decrease in the viscosity of the DNA suggest that a partial intercalation may be the preferred binding mode between these two complexes and DNA. The antibacterial activity testing revealed that the complexes and their precursor Schiff base show a weak to moderate activity against Bacillus subtilis, Staphylococcus aureus and Escherichia coli. [...]
Metal complexes of copper with isonicotinic acid and different N-donor ligands like N-Ethyl Piperazine, N-Methyl Piperazine and 4-Methyl Pyridine are synthesized. Complexes are characterized by different techniques like Elemental analysis, IR Spectroscopy, MASS Spectroscopy, Conductance and TGA. Complexes are screened for antimicrobial activity.
Content available remote Anti-staphylococcal potential of Callistemon rigidus
Open Medicine
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The last decade witnessed the emergence of Staphylococcus aureus- a versatile human pathogen, as a deadly superbug. The enormous genetic plasticity of the organism assists it to endlessly evolve resistance mechanisms against existing anti-infectives thus necessitating the need to control the spread of resistant staphylococcal isolates in hospitals and health care settings. This in turn demands the incessant exploration of newer biological matrices in search of diverse chemical entities with novel drug targets. Since time immemorial higher plants continue to be the best source of newer compounds with high therapeutic potential. Lead fractions from same or different plants can be developed into effective antibacterial polyherbal formulations. A lead fraction from methanolic extract of leaves of Callistemon rigidus exhibited a dose dependent antistaphylococcal activity during in vitro agar well assay against a panel of twenty seven clinical multidrug resistant S. aureus isolates. Further, minimal inhibitory concentration (MIC) evaluation by in vitro 96-well microplate based assay established a MIC range of 1.25–80 μg/ml as compared to 5–320 μg/ml of positive control, Cefuroxime sodium. The MIC50 and MIC90 of the methanolic lead fraction were 5 μg/ml and 40 μg/ml respectively. The present study thus signifies the vast potential of the lead fraction from Callistemon rigidus for future development into a herbal drug/ formulation and to impede global health crisis due to multidrug resistant Staphylococcus aureus.
The present study investigates phytochemical screening and antibacterial efficacy of various solvent extracts of marine algae such as Sargassum swartzii against some selected human and fish pathogenic bacteria. The brown seaweed Sargassum swartzii was collected from Kudankulam, Tirunelveli district, Tamil Nadu, India. Soxhlet extraction method was used to get the extracts of different solvents like aqueous, ethanol, methanol, acetone and were tested for their qualitative phytochemical screening using common standard tests. Quantitative phytochemical analysis such as total phenolic content and total flavonoid content of S. swartzii and antibacterial activity against human pathogens viz., Escherichia coli, Pseudomonas aeruginosa and Stephylococcus aureus and fish pathogens viz., Aeromonas hydrophila and Vibrio vulnificus bacteria using disc diffusion methods. Preliminary phytochemical screening of sixteen different chemical compounds were carried out. The maximum biochemical compounds were present in the ethanol extract and the minimum compounds were present in aqueous extract. The ethanol extract was significantly higher in phenolic content (15.35 ±2.61 mg of GAE/g) and the methanol extract was significantly higher in flavonoides content (26.92±7.14 mg of QE/g). In human pathogen the highest antibacterial activity was present in Pseudomonas aeruginosa (18.00±0.00mm) and the fish pathogen was significantly higher in Aeromonas hydrophila. The present study showed that the ethanol extract of marine brown seaweed Sargassum swartzii contains bio active constituents with highest antibacterial activity against human and fish pathogen.
Nowadays coming out of bacterial resistance poses a significant clinical problem. Hence, the aim of this study was to explain the current susceptibility patterns of methicillin-resistant Staphylococcus aureus (MRSA).As well as to find out antimicrobial characteristics in the different organic solvents with increasing polarity viz., hexane, chloroform, ethyl acetate, and methanol extracts of Padina tetrastromatica, Padina gymnospora marine macro algae belonging to the family Phaeophyta were studied. Their crude extracts were tested against Staphylococcus aureus (MTCC 737 & 7443), and three clinical isolates of MRSA were tested and has been shown to exhibit antibacterial activity against methicillin methicillin-resistant Staphylococcus aureus (MRSA). The Minimum inhibitory concentrations (MIC) and Minimum Bactericidal Concentrations (MBC) were determined. The ethyl acetate extracts of the seaweeds showed the presence of Photochemical, terpenoids, tannins, phenolic compounds and steroids strongly than the other solvent extracts. The highest activity was recorded in the ethyl acetate extract of Padina tetrastromatica than the other extract tested. The mean zone of inhibition produced by the extracts in disc diffusion assays against the tested bacterial strains ranged from 7.1 to 26.5 mm. The lowest MIC (62.5 µg/ml) and MBC (125 µg/ml) values were observed in the ethyl acetate extract of P. tetrastromatica against S. aureus (737 & 7443), MRSA1 and MRSA3. Further separation of active principle from the potential seaweed extract as a source of antibacterial compound useful for the control of Methicillin resistant S. aureus is under progress.
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